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CFLIPL protects macrophages from LPS-induced pyroptosis via inhibition of complex II formation 期刊论文
, 2020, 卷号: 367, 期号: 6484
作者:  Muendlein H.I.;  Jetton D.;  Connolly W.M.;  Eidell K.P.;  Magri Z.;  Smirnova I.;  Poltorak A.
收藏  |  浏览/下载:49/0  |  提交时间:2020/07/28
FLICE inhibitory protein  interleukin 1beta  lipopolysaccharide  messenger RNA  succinate dehydrogenase (ubiquinone)  Casp1 protein, mouse  caspase 8  Cflar protein, mouse  cryopyrin  FLICE inhibitory protein  IL1B protein, mouse  inflammasome  interleukin 1beta  interleukin 1beta converting enzyme  lipopolysaccharide  succinate dehydrogenase (ubiquinone)  cell  enzyme activity  inhibition  maturation  protein  animal cell  animal experiment  Article  bone marrow derived macrophage  cell death  cell protection  complex formation  controlled study  cytokine release  in vitro study  inflammation  mouse  nonhuman  priority journal  protein analysis  protein degradation  protein function  protein interaction  pyroptosis  animal  gene knockdown  genetics  immunology  macrophage  macrophage activation  metabolism  physiology  Murinae  Animals  CASP8 and FADD-Like Apoptosis Regulating Protein  Caspase 1  Caspase 8  Electron Transport Complex II  Gene Knockdown Techniques  Inflammasomes  Interleukin-1beta  Lipopolysaccharides  Macrophage Activation  Macrophages  Mice  NLR Family, Pyrin Domain-Containing 3 Protein  Pyroptosis  
Elesclomol alleviates Menkes pathology and mortality by escorting Cu to cuproenzymes in mice 期刊论文
, 2020, 卷号: 368, 期号: 6491
作者:  Guthrie L.M.;  Soma S.;  Yuan S.;  Silva A.;  Zulkifli M.;  Snavely T.C.;  Greene H.F.;  Nunez E.;  Lynch B.;  de Ville C.;  Shanbhag V.;  Lopez F.R.;  Acharya A.;  Petris M.J.;  Kim B.-E.;  Gohil V.M.;  Sacchettini J.C.
收藏  |  浏览/下载:37/0  |  提交时间:2020/07/28
copper  copper zinc superoxide dismutase  cytochrome c oxidase  dopamine beta monooxygenase  elesclomol  monophenol monooxygenase  protein lysine 6 oxidase  copper  cytochrome c oxidase  elesclomol  hydrazine derivative  copper  cytochrome  enzyme  enzyme activity  mitochondrion  mortality  mutation  pathology  rodent  survival  animal cell  animal experiment  animal model  animal tissue  Article  cohort analysis  controlled study  disease severity  drug mechanism  Golgi complex  H9c2(2-1) cell line  in vivo study  male  Menkes syndrome  mitochondrial dynamics  mortality rate  mouse  nerve degeneration  nonhuman  priority journal  secretory pathway  survival rate  animal  brain  cell line  degenerative disease  disease model  drug effect  genetics  knockout mouse  Menkes syndrome  metabolism  mitochondrion  pathology  rat  transport at the cellular level  Murinae  Mus  Animals  Biological Transport  Brain  Cell Line  Copper  Copper Transporter 1  Disease Models, Animal  Electron Transport Complex IV  Hydrazines  Male  Menkes Kinky Hair Syndrome  Mice  Mice, Knockout  Mitochondria  Neurodegenerative Diseases  Rats  
PE/PPE proteins mediate nutrient transport across the outer membrane of Mycobacterium tuberculosis 期刊论文
, 2020, 卷号: 367, 期号: 6482
作者:  Wang Q.;  Boshoff H.I.M.;  Harrison J.R.;  Ray P.C.;  Green S.R.;  Wyatt P.G.;  Barry Iii C.E.
收藏  |  浏览/下载:28/0  |  提交时间:2020/07/28
3,3 bis di(methylsulfonyl)propionamide  antiinfective agent  bacterial protein  glucose  glycerol  magnesium  phosphate  propionamide derivative  protein proline proline glutamate  protein proline proline glutamate 51  unclassified drug  amide  bacterial protein  lipid  phthiocerol dimycocerosate  propionamide  thiol derivative  cell component  chemical compound  membrane  mutation  protein  tuberculosis  antibiotic resistance  Article  bacterial cell  bacterial cell wall  bacterial growth  bacterial outer membrane  cell division  drug structure  Mycobacterium tuberculosis  nonhuman  nutrient uptake  priority journal  protein depletion  cell membrane  cell membrane permeability  chemistry  drug effect  gene deletion  genetics  metabolism  transport at the cellular level  Mycobacterium tuberculosis  Amides  Bacterial Proteins  Biological Transport  Cell Membrane  Cell Membrane Permeability  Drug Resistance, Bacterial  Gene Deletion  Glucose  Glycerol  Lipids  Mycobacterium tuberculosis  Sulfhydryl Compounds  
Temperature-dependent sex determination is mediated by pSTAT3 repression of Kdm6b 期刊论文
, 2020, 卷号: 368, 期号: 6488
作者:  Weber C.;  Zhou Y.;  Lee J.G.;  Looger L.L.;  Qian G.;  Ge C.;  Capel B.
收藏  |  浏览/下载:35/0  |  提交时间:2020/07/28
STAT3 protein  calcium  histone demethylase  STAT3 protein  embryonic development  gene expression  sex determination  temperature effect  turtle  animal cell  animal experiment  Article  binding site  calcium transport  cell activation  chromatin immunoprecipitation  controlled study  dimerization  Dmrt1 gene  embryo  embryo development  environmental temperature  epigenetic repression  female  gene  gene activation  gene interaction  gene targeting  genetic transcription  gonad  high temperature  immunofluorescence test  Kdm6b gene  male  nonhuman  priority journal  protein phosphorylation  real time polymerase chain reaction  sex determination  signal transduction  temperature dependence  thermoregulation  transcription regulation  upregulation  Western blotting  animal  embryology  gene expression regulation  genetics  metabolism  phosphorylation  sex determination process  temperature  turtle  Reptilia  Trachemys scripta  Trachemys scripta elegans  Animals  Calcium  Female  Gene Expression Regulation, Developmental  Jumonji Domain-Containing Histone Demethylases  Male  Phosphorylation  Sex Determination Processes  STAT3 Transcription Factor  Temperature  Transcription, Genetic  Turtles  
Dendritic cell-derived hepcidin sequesters iron from the microbiota to promote mucosal healing 期刊论文
, 2020, 卷号: 368, 期号: 6487
作者:  Bessman N.J.;  Mathieu J.R.R.;  Renassia C.;  Zhou L.;  Fung T.C.;  Fernandez K.C.;  Austin C.;  Moeller J.B.;  Zumerle S.;  Louis S.;  Vaulont S.;  Ajami N.J.;  Sokol H.;  Putzel G.G.;  Arvedson T.;  Sockolow R.E.;  Lakhal-Littleton S.;  Cloonan S.M.;  Arora M.;  Peyssonnaux C.;  Sonnenberg G.F.
收藏  |  浏览/下载:36/0  |  提交时间:2020/07/28
ferroportin  hepcidin  iron  cation transport protein  Hamp protein, mouse  hepcidin  iron  metal transporting protein 1  cell  digestive system disorder  immunity  iron  microorganism  animal cell  animal experiment  animal model  animal tissue  Article  controlled study  dendritic cell  enteritis  healing  immunity  intestine flora  intestine injury  iron blood level  iron homeostasis  iron metabolism  iron sequestration  mouse  mucosal healing  mucosal immunity  nonhuman  nutritional immunity  phagocyte  priority journal  protein expression  tissue regeneration  tissue repair  animal  dendritic cell  enteropathy  fecal microbiota transplantation  gene deletion  genetics  homeostasis  intestine mucosa  metabolism  microbiology  mutant mouse strain  physiology  Mus  Animals  Cation Transport Proteins  Dendritic Cells  Fecal Microbiota Transplantation  Gastrointestinal Microbiome  Gene Deletion  Hepcidins  Homeostasis  Intestinal Diseases  Intestinal Mucosa  Iron  Mice  Mice, Mutant Strains  Phagocytes  
A central master driver of psychosocial stress responses in the rat 期刊论文
, 2020, 卷号: 367, 期号: 6482
作者:  Kataoka N.;  Shima Y.;  Nakajima K.;  Nakamura K.
收藏  |  浏览/下载:50/0  |  提交时间:2020/07/28
vesicular glutamate transporter 1  glutamic acid  Slc17a7 protein, rat  vesicular glutamate transporter 1  brain  homeostasis  physiological response  psychology  rodent  Article  behavioral stress  brain region  emotion  forebrain  homeostasis  human  hypothalamus  in vivo study  innervation  mental stress  nerve cell  nerve tract  nonhuman  optogenetics  priority journal  social defeat  social stress  tenia tecta  thermogenesis  animal  dorsomedial hypothalamic nucleus  female  Long Evans cinnamon rat  male  mental stress  metabolism  physiology  prefrontal cortex  psychosomatic disorder  rat  signal transduction  social behavior  Wistar rat  Rattus  Animals  Dorsomedial Hypothalamic Nucleus  Emotions  Female  Glutamic Acid  Homeostasis  Male  Neurons  Prefrontal Cortex  Prosencephalon  Psychophysiologic Disorders  Rats  Rats, Inbred LEC  Rats, Wistar  Signal Transduction  Social Behavior  Stress, Psychological  Vesicular Glutamate Transport Protein 1  
Lipid-gated monovalent ion fluxes regulate endocytic traffic and support immune surveillance 期刊论文
, 2020, 卷号: 367, 期号: 6475
作者:  Freeman S.A.;  Uderhardt S.;  Saric A.;  Collins R.F.;  Buckley C.M.;  Mylvaganam S.;  Boroumand P.;  Plumb J.;  Germain R.N.;  Ren D.;  Grinstein S.
收藏  |  浏览/下载:40/0  |  提交时间:2020/07/28
cation channel  chemokine receptor CCR2  chloride  colony stimulating factor 1  epidermal growth factor  epidermal growth factor receptor  lipid  sialoadhesin  sodium ion  tetrandrine  two pore channel  unclassified drug  calcium channel  lipid  Mcoln1 protein, mouse  sodium  TPCN1 protein, mouse  TPCN2 protein, mouse  transient receptor potential channel  cation  homeostasis  immune system  protein  recycling  animal experiment  Article  bone marrow derived macrophage  cell vacuole  cell volume  channel gating  chloride transport  concentration (parameter)  controlled study  endocytosis  extracellular fluid  extracellular space  homeostasis  human  human cell  human tissue  immunosurveillance  in vitro study  internalization  ion current  knockout mouse  macropinocytosis  mouse  nonhuman  priority journal  protein stability  RNA interference  sodium transport  tonoplast  animal  cell organelle  endosome  genetics  immunology  ion transport  macrophage  metabolism  osmosis  physiology  pinocytosis  Animals  Calcium Channels  Endosomes  Immunologic Surveillance  Ion Transport  Lipids  Macrophages  Mice  Mice, Knockout  Organelles  Osmosis  Pinocytosis  Sodium  Transient Receptor Potential Channels  Vacuoles  
Structural insights into immunoglobulin M 期刊论文
, 2020, 卷号: 367, 期号: 6481
作者:  Li Y.;  Wang G.;  Li N.;  Wang Y.;  Zhu Q.;  Chu H.;  Wu W.;  Tan Y.;  Yu F.;  Su X.-D.;  Gao N.;  Xiao J.
收藏  |  浏览/下载:44/0  |  提交时间:2020/07/28
immunoglobulin M  secretory component  antibody  immunity  molecular analysis  polymer  protein  Article  binding site  conformational transition  cryoelectron microscopy  crystal structure  human  hydrophobicity  nonhuman  oligomerization  priority journal  protein assembly  protein domain  protein function  protein interaction  protein stability  protein structure  protein transport  surface area  
An RNA vaccine drives expansion and efficacy of claudin-CAR-T cells against solid tumors 期刊论文
, 2020, 卷号: 367, 期号: 6476
作者:  Reinhard K.;  Rengstl B.;  Oehm P.;  Michel K.;  Billmeier A.;  Hayduk N.;  Klein O.;  Kuna K.;  Ouchan Y.;  Wöll S.;  Christ E.;  Weber D.;  Suchan M.;  Bukur T.;  Birtel M.;  Jahndel V.;  Mroz K.;  Hobohm K.;  Kranz L.;  Diken M.;  Kühlcke K.;  Türeci Ö.;  Sahin U.
收藏  |  浏览/下载:48/0  |  提交时间:2020/07/28
chimeric antigen receptor  claudin 6  RNA vaccine  antigen  cell component  protein  RNA  tumor  vaccine  animal cell  animal experiment  animal model  animal tissue  antigen presenting cell  antineoplastic activity  Article  cell stimulation  cell transport  chimeric antigen receptor T-cell immunotherapy  controlled study  drug efficacy  human  human cell  in vivo study  mouse  nonhuman  phenotype  priority journal  real time polymerase chain reaction  solid malignant neoplasm  therapy effect  vaccination coverage  
Ion transport and regulation in a synaptic vesicle glutamate transporter 期刊论文
, 2020, 卷号: 368, 期号: 6493
作者:  Li F.;  Eriksen J.;  Finer-Moore J.;  Chang R.;  Nguyen P.;  Bowen A.;  Myasnikov A.;  Yu Z.;  Bulkley D.;  Cheng Y.;  Edwards R.H.;  Stroud R.M.
收藏  |  浏览/下载:44/0  |  提交时间:2020/07/28
brain  chemical binding  chloride  neurology  substrate  Rattus  chloride  chloride channel  glutamic acid  Slc17a6 protein, rat  vesicular glutamate transporter 2  allosterism  amino acid sequence  animal  binding site  chemistry  cryoelectron microscopy  ion transport  membrane potential  metabolism  pH  protein domain  rat  synapse vesicle  Allosteric Regulation  Amino Acid Sequence  Animals  Binding Sites  Chloride Channels  Chlorides  Cryoelectron Microscopy  Glutamic Acid  Hydrogen-Ion Concentration  Ion Transport  Membrane Potentials  Protein Domains  Rats  Synaptic Vesicles  Vesicular Glutamate Transport Protein 2