气候变化领域集成服务门户(CCPortal): Structural insights into immunoglobulin M

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DOI	10.1126/science.aaz5425
	Structural insights into immunoglobulin M
	Li Y.; Wang G.; Li N.; Wang Y.; Zhu Q.; Chu H.; Wu W.; Tan Y.; Yu F.; Su X.-D.; Gao N.; Xiao J.
发表日期	2020
ISSN	0036-8075
起始页码	1014
结束页码	1017
卷号	367 期号:6481
英文摘要	Immunoglobulin M (IgM) plays a pivotal role in both humoral and mucosal immunity. Its assembly and transport depend on the joining chain (J-chain) and the polymeric immunoglobulin receptor (pIgR), but the underlying molecular mechanisms of these processes are unclear. We report a cryo-electron microscopy structure of the Fc region of human IgM in complex with the J-chain and pIgR ectodomain. The IgM-Fc pentamer is formed asymmetrically, resembling a hexagon with a missing triangle. The tailpieces of IgM-Fc pack into an amyloid-like structure to stabilize the pentamer. The J-chain caps the tailpiece assembly and bridges the interaction between IgM-Fc and the polymeric immunoglobulin receptor, which undergoes a large conformational change to engage the IgM-J complex. These results provide a structural basis for the function of IgM. Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works
关键词	immunoglobulin M secretory component antibody immunity molecular analysis polymer protein Article binding site conformational transition cryoelectron microscopy crystal structure human hydrophobicity nonhuman oligomerization priority journal protein assembly protein domain protein function protein interaction protein stability protein structure protein transport surface area
语种	英语
来源机构	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/133683
推荐引用方式 GB/T 7714	Li Y.,Wang G.,Li N.,et al. Structural insights into immunoglobulin M[J]. Science,2020,367(6481).
APA	Li Y..,Wang G..,Li N..,Wang Y..,Zhu Q..,...&Xiao J..(2020).Structural insights into immunoglobulin M.,367(6481).
MLA	Li Y.,et al."Structural insights into immunoglobulin M".367.6481(2020).