气候变化领域集成服务门户(CCPortal): Dendritic cell-derived hepcidin sequesters iron from the microbiota to promote mucosal healing

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DOI	10.1126/science.aau6481
	Dendritic cell-derived hepcidin sequesters iron from the microbiota to promote mucosal healing
	Bessman N.J.; Mathieu J.R.R.; Renassia C.; Zhou L.; Fung T.C.; Fernandez K.C.; Austin C.; Moeller J.B.; Zumerle S.; Louis S.; Vaulont S.; Ajami N.J.; Sokol H.; Putzel G.G.; Arvedson T.; Sockolow R.E.; Lakhal-Littleton S.; Cloonan S.M.; Arora M.; Peyssonnaux C.; Sonnenberg G.F.
发表日期	2020
ISSN	0036-8075
起始页码	186
结束页码	189
卷号	368 期号:6487
英文摘要	Bleeding and altered iron distribution occur in multiple gastrointestinal diseases, but the importance and regulation of these changes remain unclear. We found that hepcidin, the master regulator of systemic iron homeostasis, is required for tissue repair in the mouse intestine after experimental damage. This effect was independent of hepatocyte-derived hepcidin or systemic iron levels. Rather, we identified conventional dendritic cells (cDCs) as a source of hepcidin that is induced by microbial stimulation in mice, prominent in the inflamed intestine of humans, and essential for tissue repair. cDC-derived hepcidin acted on ferroportin-expressing phagocytes to promote local iron sequestration, which regulated the microbiota and consequently facilitated intestinal repair. Collectively, these results identify a pathway whereby cDC-derived hepcidin promotes mucosal healing in the intestine through means of nutritional immunity. © 2020 The Authors.
关键词	ferroportin hepcidin iron cation transport protein Hamp protein, mouse hepcidin iron metal transporting protein 1 cell digestive system disorder immunity iron microorganism animal cell animal experiment animal model animal tissue Article controlled study dendritic cell enteritis healing immunity intestine flora intestine injury iron blood level iron homeostasis iron metabolism iron sequestration mouse mucosal healing mucosal immunity nonhuman nutritional immunity phagocyte priority journal protein expression tissue regeneration tissue repair animal dendritic cell enteropathy fecal microbiota transplantation gene deletion genetics homeostasis intestine mucosa metabolism microbiology mutant mouse strain physiology Mus Animals Cation Transport Proteins Dendritic Cells Fecal Microbiota Transplantation Gastrointestinal Microbiome Gene Deletion Hepcidins Homeostasis Intestinal Diseases Intestinal Mucosa Iron Mice Mice, Mutant Strains Phagocytes
语种	英语
来源机构	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/133568
推荐引用方式 GB/T 7714	Bessman N.J.,Mathieu J.R.R.,Renassia C.,et al. Dendritic cell-derived hepcidin sequesters iron from the microbiota to promote mucosal healing[J]. Science,2020,368(6487).
APA	Bessman N.J..,Mathieu J.R.R..,Renassia C..,Zhou L..,Fung T.C..,...&Sonnenberg G.F..(2020).Dendritic cell-derived hepcidin sequesters iron from the microbiota to promote mucosal healing.,368(6487).
MLA	Bessman N.J.,et al."Dendritic cell-derived hepcidin sequesters iron from the microbiota to promote mucosal healing".368.6487(2020).