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| DOI | 10.1126/science.aaw7182 |
| A central master driver of psychosocial stress responses in the rat | |
| Kataoka N.; Shima Y.; Nakajima K.; Nakamura K. | |
| 发表日期 | 2020 |
| ISSN | 0036-8075 |
| 起始页码 | 1105 |
| 结束页码 | 1112 |
| 卷号 | 367期号:6482 |
| 英文摘要 | The mechanism by which psychological stress elicits various physiological responses is unknown. We discovered a central master neural pathway in rats that drives autonomic and behavioral stress responses by connecting the corticolimbic stress circuits to the hypothalamus. Psychosocial stress signals from emotion-related forebrain regions activated a VGLUT1-positive glutamatergic pathway from the dorsal peduncular cortex and dorsal tenia tecta (DP/DTT), an unexplored prefrontal cortical area, to the dorsomedial hypothalamus (DMH), a hypothalamic autonomic center. Genetic ablation and optogenetics revealed that the DP/DTT→DMH pathway drives thermogenic, hyperthermic, and cardiovascular sympathetic responses to psychosocial stress without contributing to basal homeostasis. This pathway also mediates avoidance behavior from psychosocial stressors. Given the variety of stress responses driven by the DP/DTT→DMH pathway, the DP/DTT can be a potential target for treating psychosomatic disorders. © 2020 American Association for the Advancement of Science. All rights reserved. |
| 关键词 | vesicular glutamate transporter 1glutamic acidSlc17a7 protein, ratvesicular glutamate transporter 1brainhomeostasisphysiological responsepsychologyrodentArticlebehavioral stressbrain regionemotionforebrainhomeostasishumanhypothalamusin vivo studyinnervationmental stressnerve cellnerve tractnonhumanoptogeneticspriority journalsocial defeatsocial stresstenia tectathermogenesisanimaldorsomedial hypothalamic nucleusfemaleLong Evans cinnamon ratmalemental stressmetabolismphysiologyprefrontal cortexpsychosomatic disorderratsignal transductionsocial behaviorWistar ratRattusAnimalsDorsomedial Hypothalamic NucleusEmotionsFemaleGlutamic AcidHomeostasisMaleNeuronsPrefrontal CortexProsencephalonPsychophysiologic DisordersRatsRats, Inbred LECRats, WistarSignal TransductionSocial BehaviorStress, PsychologicalVesicular Glutamate Transport Protein 1 |
| 语种 | 英语 |
| 来源机构 | Science |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/133664 |
| 推荐引用方式 GB/T 7714 | Kataoka N.,Shima Y.,Nakajima K.,et al. A central master driver of psychosocial stress responses in the rat[J]. Science,2020,367(6482). |
| APA | Kataoka N.,Shima Y.,Nakajima K.,&Nakamura K..(2020).A central master driver of psychosocial stress responses in the rat.,367(6482). |
| MLA | Kataoka N.,et al."A central master driver of psychosocial stress responses in the rat".367.6482(2020). |
| 条目包含的文件 | 条目无相关文件。 | |||||
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