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Structure of the RNA-dependent RNA polymerase from COVID-19 virus 期刊论文
, 2020, 卷号: 368, 期号: 6492
作者:  Gao Y.;  Yan L.;  Huang Y.;  Liu F.;  Zhao Y.;  Cao L.;  Wang T.;  Sun Q.;  Ming Z.;  Zhang L.;  Ge J.;  Zheng L.;  Zhang Y.;  Wang H.;  Zhu Y.;  Zhu C.;  Hu T.;  Hua T.;  Zhang B.;  Yang X.;  Li J.;  Yang H.;  Liu Z.;  Xu W.;  Guddat L.W.;  Wang Q.;  Lou Z.;  Rao Z.
收藏  |  浏览/下载：51/0  |  提交时间：2020/07/28
comparative study  drug  electron microscopy  enzyme  enzyme activity  RNA  virus  Coronavirus  SARS coronavirus  adenosine phosphate  alanine  antivirus agent  NSP7 protein, SARS-CoV-2  NSP8 protein, SARS-CoV-2  remdesivir  RNA directed RNA polymerase  RNA-dependent RNA polymerase, coronavirus  viral protein  beta sheet  Betacoronavirus  chemistry  cryoelectron microscopy  drug design  enzyme active site  enzymology  metabolism  molecular model  protein domain  ultrastructure  Adenosine Monophosphate  Alanine  Antiviral Agents  Betacoronavirus  Catalytic Domain  Cryoelectron Microscopy  Drug Design  Models, Molecular  Protein Conformation, beta-Strand  Protein Domains  RNA Replicase  Viral Nonstructural Proteins  
Unconstrained genome targeting with near-PAMless engineered CRISPR-Cas9 variants 期刊论文
, 2020, 卷号: 368, 期号: 6488
作者:  Walton R.T.;  Christie K.A.;  Whittaker M.N.;  Kleinstiver B.P.
收藏  |  浏览/下载：27/0  |  提交时间：2020/07/28
adenine  adenosine  CRISPR associated endonuclease Cas9  cytosine  guanosine  SpG protein  SpRY nuclease  thymine  unclassified drug  Cas9 endonuclease Streptococcus pyogenes  bacterium  enzyme activity  genetic engineering  genetic variation  genome  Article  CRISPR-CAS9 system  DNA sequence  enzyme activity  gene editing  gene targeting  genetic variability  human  mutagenesis  nonhuman  priority journal  protein engineering  protein motif  protein structure  protospacer adjacent motif  Streptococcus pyogenes  chemistry  CRISPR Cas system  enzyme specificity  gene editing  gene targeting  genetic predisposition  genetics  HEK293 cell line  procedures  protein domain  Streptococcus pyogenes  CRISPR-Associated Protein 9  CRISPR-Cas Systems  Gene Editing  Gene Targeting  Genetic Predisposition to Disease  HEK293 Cells  Humans  Mutagenesis  Protein Domains  Substrate Specificity  
Valence and patterning of aromatic residues determine the phase behavior of prion-like domains 期刊论文
, 2020, 卷号: 367, 期号: 6478
作者:  Martin E.W.;  Holehouse A.S.;  Peran I.;  Farag M.;  Incicco J.J.;  Bremer A.;  Grace C.R.;  Soranno A.;  Pappu R.V.;  Mittag T.
收藏  |  浏览/下载：21/0  |  提交时间：2020/07/28
aromatic hydrocarbon  biophysics  concentration (composition)  genetic analysis  nuclear magnetic resonance  prion disease  protein  separation  temperature effect  article  nonhuman  nuclear magnetic resonance spectroscopy  phase separation  prediction  prion  simulation  X ray crystallography  amino acid sequence  chemistry  phase transition  prion  protein domain  small angle scattering  X ray diffraction  heterogeneous nuclear ribonucleoprotein A1  phenylalanine  tyrosine  Amino Acid Sequence  Heterogeneous Nuclear Ribonucleoprotein A1  Magnetic Resonance Spectroscopy  Phase Transition  Phenylalanine  Prions  Protein Domains  Scattering, Small Angle  Tyrosine  X-Ray Diffraction  
A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV 期刊论文
, 2020, 卷号: 368, 期号: 6491
作者:  Yuan M.;  Wu N.C.;  Zhu X.;  Lee C.-C.D.;  So R.T.Y.;  Lv H.;  Mok C.K.P.;  Wilson I.A.
收藏  |  浏览/下载：26/0  |  提交时间：2020/07/28
angiotensin converting enzyme 2  epitope  neutralizing antibody  virus hemagglutinin  virus spike protein  angiotensin converting enzyme 2  coronavirus receptors  coronavirus spike glycoprotein  dipeptidyl carboxypeptidase  epitope  neutralizing antibody  spike glycoprotein, SARS-CoV  spike protein, SARS-CoV-2  virus antibody  virus antigen  virus receptor  antibody  antigen  chemical binding  crystal structure  protein  respiratory disease  viral disease  virus  amino terminal sequence  antibody isolation  antigen binding  antigenicity  Article  binding affinity  binding site  conservation biology  controlled study  coronavirus disease 2019  cross reaction  cryoelectron microscopy  crystal structure  enzyme linked immunosorbent assay  epidemic  glycosylation  human  hydrophobicity  immune response  in vitro study  in vivo study  light chain  nonhuman  priority journal  protein conformation  protein domain  protein interaction  protein localization  protein structure  protein targeting  receptor binding  SARS coronavirus  Severe acute respiratory syndrome coronavirus 2  amino acid sequence  antibody affinity  Betacoronavirus  binding site  chemistry  immunology  metabolism  molecular model  SARS coronavirus  X ray crystallography  Coronavirus  SARS coronavirus  Amino Acid Sequence  Antibodies, Neutralizing  Antibodies, Viral  Antibody Affinity  Antigens, Viral  Betacoronavirus  Binding Sites  Cross Reactions  Crystallography, X-Ray  Epitopes  Models, Molecular  Peptidyl-Dipeptidase A  Protein Conformation  Protein Domains  Protein Interaction Domains and Motifs  Receptors, Virus  SARS Virus  Spike Glycoprotein, Coronavirus  
Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells 期刊论文
, 2020, 卷号: 368, 期号: 6494
作者:  Zhou Z.;  He H.;  Wang K.;  Shi X.;  Wang Y.;  Su Y.;  Wang Y.;  Li D.;  Liu W.;  Zhang Y.;  Shen L.;  Han W.;  Shen L.;  Ding J.;  Shao F.
收藏  |  浏览/下载：36/0  |  提交时间：2020/07/28
cell  cell component  cytology  enzyme  enzyme activity  gene expression  immunity  tumor  Mus  gamma interferon  granzyme  GSDMB protein, human  GZMA protein, human  pore forming cytotoxic protein  tumor protein  animal  Bagg albino mouse  chemistry  cytotoxic T lymphocyte  enzymology  genetics  HEK293 cell line  human  immunology  metabolism  mouse  natural killer cell  neoplasm  pathology  protein degradation  protein domain  pyroptosis  transgenic mouse  Animals  Granzymes  HEK293 Cells  Humans  Interferon-gamma  Killer Cells, Natural  Mice  Mice, Inbred BALB C  Mice, Transgenic  Neoplasm Proteins  Neoplasms  Pore Forming Cytotoxic Proteins  Protein Domains  Proteolysis  Pyroptosis  T-Lymphocytes, Cytotoxic  
A noncompeting pair of human neutralizing antibodies block COVID-19 virus binding to its receptor ACE2 期刊论文
, 2020, 卷号: 368, 期号: 6496
作者:  Wu Y.;  Wang F.;  Shen C.;  Peng W.;  Li D.;  Zhao C.;  Li Z.;  Li S.;  Bi Y.;  Yang Y.;  Gong Y.;  Xiao H.;  Fan Z.;  Tan S.;  Wu G.;  Tan W.;  Lu X.;  Fan C.;  Wang Q.;  Liu Y.;  Zhang C.;  Qi J.;  Gao G.F.;  Gao F.;  Liu L.
收藏  |  浏览/下载：38/0  |  提交时间：2020/07/28
Coronavirus  angiotensin converting enzyme 2  coronavirus spike glycoprotein  dipeptidyl carboxypeptidase  epitope  monoclonal antibody  neutralizing antibody  virus antibody  virus receptor  animal  chemistry  Coronavirus infection  disease model  human  immunology  isolation and purification  lung  mouse  pandemic  protein domain  serodiagnosis  virology  virus load  virus pneumonia  Animals  Antibodies, Monoclonal  Antibodies, Neutralizing  Antibodies, Viral  Coronavirus Infections  Disease Models, Animal  Humans  Immunodominant Epitopes  Lung  Mice  Neutralization Tests  Pandemics  Peptidyl-Dipeptidase A  Pneumonia, Viral  Protein Domains  Receptors, Virus  Spike Glycoprotein, Coronavirus  Viral Load  
Synthesis of proteins by automated flow chemistry 期刊论文
, 2020, 卷号: 368, 期号: 6494
作者:  Hartrampf N.;  Saebi A.;  Poskus M.;  Gates Z.P.;  Callahan A.J.;  Cowfer A.E.;  Hanna S.;  Antilla S.;  Schissel C.K.;  Quartararo A.J.;  Ye X.;  Mijalis A.J.;  Simon M.D.;  Loas A.;  Liu S.;  Jessen C.;  Nielsen T.E.;  Pentelute B.L.
收藏  |  浏览/下载：42/0  |  提交时间：2020/07/28
amino acid  cell component  chemistry  instrumentation  peptide  protein  purification  peptide  protein  chemistry  isolation and purification  procedures  protein domain  protein folding  solid phase synthesis  synthesis  Peptides  Protein Domains  Protein Folding  Proteins  Solid-Phase Synthesis Techniques  
Ion transport and regulation in a synaptic vesicle glutamate transporter 期刊论文
, 2020, 卷号: 368, 期号: 6493
作者:  Li F.;  Eriksen J.;  Finer-Moore J.;  Chang R.;  Nguyen P.;  Bowen A.;  Myasnikov A.;  Yu Z.;  Bulkley D.;  Cheng Y.;  Edwards R.H.;  Stroud R.M.
收藏  |  浏览/下载：43/0  |  提交时间：2020/07/28
brain  chemical binding  chloride  neurology  substrate  Rattus  chloride  chloride channel  glutamic acid  Slc17a6 protein, rat  vesicular glutamate transporter 2  allosterism  amino acid sequence  animal  binding site  chemistry  cryoelectron microscopy  ion transport  membrane potential  metabolism  pH  protein domain  rat  synapse vesicle  Allosteric Regulation  Amino Acid Sequence  Animals  Binding Sites  Chloride Channels  Chlorides  Cryoelectron Microscopy  Glutamic Acid  Hydrogen-Ion Concentration  Ion Transport  Membrane Potentials  Protein Domains  Rats  Synaptic Vesicles  Vesicular Glutamate Transport Protein 2  
Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2 期刊论文
, 2020, 卷号: 367, 期号: 6485
作者:  Yan R.;  Zhang Y.;  Li Y.;  Xia L.;  Guo Y.;  Zhou Q.
收藏  |  浏览/下载：24/0  |  提交时间：2020/07/28
angiotensin converting enzyme 2  coronavirus spike glycoprotein  heterodimer  homodimer  amino acid transporter  angiotensin converting enzyme 2  dipeptidyl carboxypeptidase  protein binding  SLC6A19 protein, human  spike protein, SARS-CoV-2  virus receptor  enzyme  gene  gene expression  protein  ultrastructure  virus  Article  binding site  complex formation  controlled study  coronavirus disease 2019  cryoelectron microscopy  dimerization  embryo  enzyme structure  human  human cell  nonhuman  priority journal  protein domain  SARS-related coronavirus  Severe acute respiratory syndrome coronavirus 2  amino acid sequence  Betacoronavirus  Coronavirus infection  molecular model  pandemic  protein multimerization  SARS coronavirus  sequence alignment  ultrastructure  virus pneumonia  Coronavirus  SARS coronavirus  Amino Acid Sequence  Amino Acid Transport Systems, Neutral  Betacoronavirus  Coronavirus Infections  Cryoelectron Microscopy  Humans  Models, Molecular  Pandemics  Peptidyl-Dipeptidase A  Pneumonia, Viral  Protein Binding  Protein Domains  Protein Multimerization  Receptors, Virus  SARS Virus  Sequence Alignment  Spike Glycoprotein, Coronavirus  
Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation 期刊论文
, 2020, 卷号: 367, 期号: 6483
作者:  Wrapp D.;  Wang N.;  Corbett K.S.;  Goldsmith J.A.;  Hsieh C.-L.;  Abiona O.;  Graham B.S.;  McLellan J.S.
收藏  |  浏览/下载：36/0  |  提交时间：2020/07/28
2019 nCoV S protein  angiotensin converting enzyme 2  unclassified drug  viral protein  angiotensin converting enzyme 2  coronavirus spike glycoprotein  dipeptidyl carboxypeptidase  monoclonal antibody  protein binding  severe acute respiratory syndrome coronavirus 2  virus antibody  virus receptor  antibody  detection method  electron microscopy  protein  public health  severe acute respiratory syndrome  virus  Article  binding affinity  biophysics  corona virus disease 2019  coronavirus disease 2019  Coronavirus infection  cross reaction  cryoelectron microscopy  molecular dynamics  nonhuman  priority journal  protein binding  protein structure  SARS coronavirus  Severe acute respiratory syndrome coronavirus 2  virus transmission  virus virulence  Betacoronavirus  chemistry  cryoelectron microscopy  image processing  immunology  metabolism  molecular model  protein conformation  protein domain  protein multimerization  ultrastructure  Coronavirus  SARS coronavirus  Antibodies, Monoclonal  Antibodies, Viral  Betacoronavirus  Cross Reactions  Cryoelectron Microscopy  Image Processing, Computer-Assisted  Models, Molecular  Peptidyl-Dipeptidase A  Protein Binding  Protein Conformation  Protein Domains  Protein Multimerization  Receptors, Virus  SARS Virus  Spike Glycoprotein, Coronavirus