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Coronavirus replication-transcription complex: Vital and selective NMPylation of a conserved site in nsp9 by the NiRAN-RdRp subunit 期刊论文
Proceedings of the National Academy of Sciences of the United States of America, 2021, 卷号: 118, 期号: 6
作者:  Slanina H.;  Madhugiri R.;  Bylapudi G.;  Schultheiß K.;  Karl N.;  Gulyaeva A.;  Gorbalenya A.E.;  Linne U.;  Ziebuhr J.
收藏  |  浏览/下载：76/0  |  提交时间：2021/05/24
Embryonic exposure to hyper glucocorticoids suppresses brown fat development and thermogenesis via REDD1 期刊论文
Science Bulletin, 2021, 卷号: 66, 期号: 5
作者:  Chen Y.-T.;  Hu Y.;  Yang Q.-Y.;  Liu X.-D.;  Son J.S.;  de Avila J.M.;  Zhu M.-J.;  Du M.
收藏  |  浏览/下载：22/0  |  提交时间：2021/09/01
Brown fat  Fetus  Glucocorticoids  Maternal stress  Mitochondrial biogenesis  REDD1  
TBK1 recruitment to STING activates both IRF3 and NF-κB that mediate immune defense against tumors and viral infections 期刊论文
Proceedings of the National Academy of Sciences of the United States of America, 2021, 卷号: 118, 期号: 14
作者:  Yum S.;  Li M.;  Fang Y.;  Chen Z.J.
收藏  |  浏览/下载：28/0  |  提交时间：2021/05/24
Cell dispersal by localized degradation of a chemoattractant 期刊论文
Proceedings of the National Academy of Sciences of the United States of America, 2021, 卷号: 118, 期号: 6
作者:  Karmakar R.;  Tyree T.;  Gomer R.H.;  Rappel W.-J.
收藏  |  浏览/下载：0/0  |  提交时间：2021/05/24
Rapid Ca2+ channel accumulation contributes to cAMP-mediated increase in transmission at hippocampal mossy fiber synapses 期刊论文
Proceedings of the National Academy of Sciences of the United States of America, 2021, 卷号: 118, 期号: 9
作者:  Fukaya R.;  Maglione M.;  Sigrist S.J.;  Sakaba T.
收藏  |  浏览/下载：10/0  |  提交时间：2021/05/24
ROS and hypoxia signaling regulate periodic metabolic arousal during insect dormancy to coordinate glucose, amino acid, and lipid metabolism 期刊论文
Proceedings of the National Academy of Sciences of the United States of America, 2021, 卷号: 118, 期号: 1
作者:  Chen C.;  Mahar R.;  Merritt M.E.;  Denlinger D.L.;  Hahn D.A.
收藏  |  浏览/下载：19/0  |  提交时间：2021/05/24
Structure of the RNA-dependent RNA polymerase from COVID-19 virus 期刊论文
, 2020, 卷号: 368, 期号: 6492
作者:  Gao Y.;  Yan L.;  Huang Y.;  Liu F.;  Zhao Y.;  Cao L.;  Wang T.;  Sun Q.;  Ming Z.;  Zhang L.;  Ge J.;  Zheng L.;  Zhang Y.;  Wang H.;  Zhu Y.;  Zhu C.;  Hu T.;  Hua T.;  Zhang B.;  Yang X.;  Li J.;  Yang H.;  Liu Z.;  Xu W.;  Guddat L.W.;  Wang Q.;  Lou Z.;  Rao Z.
收藏  |  浏览/下载：35/0  |  提交时间：2020/07/28
comparative study  drug  electron microscopy  enzyme  enzyme activity  RNA  virus  Coronavirus  SARS coronavirus  adenosine phosphate  alanine  antivirus agent  NSP7 protein, SARS-CoV-2  NSP8 protein, SARS-CoV-2  remdesivir  RNA directed RNA polymerase  RNA-dependent RNA polymerase, coronavirus  viral protein  beta sheet  Betacoronavirus  chemistry  cryoelectron microscopy  drug design  enzyme active site  enzymology  metabolism  molecular model  protein domain  ultrastructure  Adenosine Monophosphate  Alanine  Antiviral Agents  Betacoronavirus  Catalytic Domain  Cryoelectron Microscopy  Drug Design  Models, Molecular  Protein Conformation, beta-Strand  Protein Domains  RNA Replicase  Viral Nonstructural Proteins  
Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir 期刊论文
, 2020, 卷号: 368, 期号: 6498
作者:  Yin W.;  Mao C.;  Luan X.;  Shen D.-D.;  Shen Q.;  Su H.;  Wang X.;  Zhou F.;  Zhao W.;  Gao M.;  Chang S.;  Xie Y.-C.;  Tian G.;  Jiang H.-W.;  Tao S.-C.;  Shen J.;  Jiang Y.;  Jiang H.;  Xu Y.;  Zhang S.;  Zhang Y.;  Xu H.E.
收藏  |  浏览/下载：90/0  |  提交时间：2020/07/28
adenosine phosphate  alanine  antivirus agent  enzyme inhibitor  multiprotein complex  NSP7 protein, SARS-CoV-2  NSP8 protein, SARS-CoV-2  remdesivir  RNA directed RNA polymerase  RNA-dependent RNA polymerase, coronavirus  viral protein  virus RNA  Betacoronavirus  chemistry  cryoelectron microscopy  drug effect  enzyme active site  enzymology  metabolism  molecular model  physiology  protein conformation  virus replication  Adenosine Monophosphate  Alanine  Antiviral Agents  Betacoronavirus  Catalytic Domain  Cryoelectron Microscopy  Enzyme Inhibitors  Models, Molecular  Multiprotein Complexes  Protein Conformation  RNA Replicase  RNA, Viral  Viral Nonstructural Proteins  Virus Replication  
Metabolomics and mass spectrometry imaging reveal channeled de novo purine synthesis in cells 期刊论文
, 2020, 卷号: 368, 期号: 6488
作者:  Pareek V.;  Tian H.;  Winograd N.;  Benkovic S.J.
收藏  |  浏览/下载：30/0  |  提交时间：2020/07/28
adenosine phosphate  guanosine phosphate  multienzyme complex  nucleotide  purine  purine  purine derivative  cell  experimental study  imaging method  mass spectrometry  metabolism  protein  Article  biochemistry  enzyme assay  gas cluster ion beam secondary ion mass spectrometry  image analysis  mass spectrometry  metabolomics  mitochondrion  molecular imaging  molecular probe  priority journal  purine synthesis  reaction analysis  single cell analysis  biosynthesis  fluorescence imaging  HeLa cell line  human  metabolism  metabolomics  procedures  secondary ion mass spectrometry  HeLa Cells  Humans  Metabolomics  Mitochondria  Multienzyme Complexes  Optical Imaging  Purines  Single-Cell Analysis  Spectrometry, Mass, Secondary Ion  
Pulmonary surfactant-biomimetic nanoparticles potentiate heterosubtypic influenza immunity 期刊论文
, 2020, 卷号: 367, 期号: 6480
作者:  Wang J.;  Li P.;  Yu Y.;  Fu Y.;  Jiang H.;  Lu M.;  Sun Z.;  Jiang S.;  Lu L.;  Wu M.X.
收藏  |  浏览/下载：32/0  |  提交时间：2020/07/28
2',3' cyclic guanosine monophosphate adenosine monophosphate  influenza vaccine  interferon  nanoparticle  pulmonary surfactant biomimetic nanoparticle  purine nucleotide  surfactant protein A  surfactant protein D  unclassified drug  cell  drug resistance  immune response  immunity  induced response  influenza  nanoparticle  rodent  surfactant  vaccine  animal cell  animal experiment  animal model  animal tissue  Article  CD8+ T lymphocyte  cellular immunity  controlled study  cross protection  cytokine response  drug efficacy  drug safety  drug synthesis  female  human  humoral immunity  hydrophilicity  immune response  immunopathology  immunosurveillance  influenza  innate immunity  lung alveolus epithelium cell  lung alveolus macrophage  mouse  Mustela putorius furo  nanoencapsulation  nonhuman  priority journal  Mus  Mustela