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Coronavirus replication-transcription complex: Vital and selective NMPylation of a conserved site in nsp9 by the NiRAN-RdRp subunit
期刊论文
Proceedings of the National Academy of Sciences of the United States of America, 2021, 卷号: 118, 期号: 6
作者:
Slanina H.
;
Madhugiri R.
;
Bylapudi G.
;
Schultheiß K.
;
Karl N.
;
Gulyaeva A.
;
Gorbalenya A.E.
;
Linne U.
;
Ziebuhr J.
收藏
  |  
浏览/下载:76/0
  |  
提交时间:2021/05/24
Embryonic exposure to hyper glucocorticoids suppresses brown fat development and thermogenesis via REDD1
期刊论文
Science Bulletin, 2021, 卷号: 66, 期号: 5
作者:
Chen Y.-T.
;
Hu Y.
;
Yang Q.-Y.
;
Liu X.-D.
;
Son J.S.
;
de Avila J.M.
;
Zhu M.-J.
;
Du M.
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2021/09/01
Brown fat
Fetus
Glucocorticoids
Maternal stress
Mitochondrial biogenesis
REDD1
TBK1 recruitment to STING activates both IRF3 and NF-κB that mediate immune defense against tumors and viral infections
期刊论文
Proceedings of the National Academy of Sciences of the United States of America, 2021, 卷号: 118, 期号: 14
作者:
Yum S.
;
Li M.
;
Fang Y.
;
Chen Z.J.
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2021/05/24
Cell dispersal by localized degradation of a chemoattractant
期刊论文
Proceedings of the National Academy of Sciences of the United States of America, 2021, 卷号: 118, 期号: 6
作者:
Karmakar R.
;
Tyree T.
;
Gomer R.H.
;
Rappel W.-J.
收藏
  |  
浏览/下载:0/0
  |  
提交时间:2021/05/24
Rapid Ca2+ channel accumulation contributes to cAMP-mediated increase in transmission at hippocampal mossy fiber synapses
期刊论文
Proceedings of the National Academy of Sciences of the United States of America, 2021, 卷号: 118, 期号: 9
作者:
Fukaya R.
;
Maglione M.
;
Sigrist S.J.
;
Sakaba T.
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2021/05/24
ROS and hypoxia signaling regulate periodic metabolic arousal during insect dormancy to coordinate glucose, amino acid, and lipid metabolism
期刊论文
Proceedings of the National Academy of Sciences of the United States of America, 2021, 卷号: 118, 期号: 1
作者:
Chen C.
;
Mahar R.
;
Merritt M.E.
;
Denlinger D.L.
;
Hahn D.A.
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2021/05/24
Structure of the RNA-dependent RNA polymerase from COVID-19 virus
期刊论文
, 2020, 卷号: 368, 期号: 6492
作者:
Gao Y.
;
Yan L.
;
Huang Y.
;
Liu F.
;
Zhao Y.
;
Cao L.
;
Wang T.
;
Sun Q.
;
Ming Z.
;
Zhang L.
;
Ge J.
;
Zheng L.
;
Zhang Y.
;
Wang H.
;
Zhu Y.
;
Zhu C.
;
Hu T.
;
Hua T.
;
Zhang B.
;
Yang X.
;
Li J.
;
Yang H.
;
Liu Z.
;
Xu W.
;
Guddat L.W.
;
Wang Q.
;
Lou Z.
;
Rao Z.
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2020/07/28
comparative study
drug
electron microscopy
enzyme
enzyme activity
RNA
virus
Coronavirus
SARS coronavirus
adenosine phosphate
alanine
antivirus agent
NSP7 protein, SARS-CoV-2
NSP8 protein, SARS-CoV-2
remdesivir
RNA directed RNA polymerase
RNA-dependent RNA polymerase, coronavirus
viral protein
beta sheet
Betacoronavirus
chemistry
cryoelectron microscopy
drug design
enzyme active site
enzymology
metabolism
molecular model
protein domain
ultrastructure
Adenosine Monophosphate
Alanine
Antiviral Agents
Betacoronavirus
Catalytic Domain
Cryoelectron Microscopy
Drug Design
Models, Molecular
Protein Conformation, beta-Strand
Protein Domains
RNA Replicase
Viral Nonstructural Proteins
Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir
期刊论文
, 2020, 卷号: 368, 期号: 6498
作者:
Yin W.
;
Mao C.
;
Luan X.
;
Shen D.-D.
;
Shen Q.
;
Su H.
;
Wang X.
;
Zhou F.
;
Zhao W.
;
Gao M.
;
Chang S.
;
Xie Y.-C.
;
Tian G.
;
Jiang H.-W.
;
Tao S.-C.
;
Shen J.
;
Jiang Y.
;
Jiang H.
;
Xu Y.
;
Zhang S.
;
Zhang Y.
;
Xu H.E.
收藏
  |  
浏览/下载:90/0
  |  
提交时间:2020/07/28
adenosine phosphate
alanine
antivirus agent
enzyme inhibitor
multiprotein complex
NSP7 protein, SARS-CoV-2
NSP8 protein, SARS-CoV-2
remdesivir
RNA directed RNA polymerase
RNA-dependent RNA polymerase, coronavirus
viral protein
virus RNA
Betacoronavirus
chemistry
cryoelectron microscopy
drug effect
enzyme active site
enzymology
metabolism
molecular model
physiology
protein conformation
virus replication
Adenosine Monophosphate
Alanine
Antiviral Agents
Betacoronavirus
Catalytic Domain
Cryoelectron Microscopy
Enzyme Inhibitors
Models, Molecular
Multiprotein Complexes
Protein Conformation
RNA Replicase
RNA, Viral
Viral Nonstructural Proteins
Virus Replication
Metabolomics and mass spectrometry imaging reveal channeled de novo purine synthesis in cells
期刊论文
, 2020, 卷号: 368, 期号: 6488
作者:
Pareek V.
;
Tian H.
;
Winograd N.
;
Benkovic S.J.
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2020/07/28
adenosine phosphate
guanosine phosphate
multienzyme complex
nucleotide
purine
purine
purine derivative
cell
experimental study
imaging method
mass spectrometry
metabolism
protein
Article
biochemistry
enzyme assay
gas cluster ion beam secondary ion mass spectrometry
image analysis
mass spectrometry
metabolomics
mitochondrion
molecular imaging
molecular probe
priority journal
purine synthesis
reaction analysis
single cell analysis
biosynthesis
fluorescence imaging
HeLa cell line
human
metabolism
metabolomics
procedures
secondary ion mass spectrometry
HeLa Cells
Humans
Metabolomics
Mitochondria
Multienzyme Complexes
Optical Imaging
Purines
Single-Cell Analysis
Spectrometry, Mass, Secondary Ion
Pulmonary surfactant-biomimetic nanoparticles potentiate heterosubtypic influenza immunity
期刊论文
, 2020, 卷号: 367, 期号: 6480
作者:
Wang J.
;
Li P.
;
Yu Y.
;
Fu Y.
;
Jiang H.
;
Lu M.
;
Sun Z.
;
Jiang S.
;
Lu L.
;
Wu M.X.
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2020/07/28
2',3' cyclic guanosine monophosphate adenosine monophosphate
influenza vaccine
interferon
nanoparticle
pulmonary surfactant biomimetic nanoparticle
purine nucleotide
surfactant protein A
surfactant protein D
unclassified drug
cell
drug resistance
immune response
immunity
induced response
influenza
nanoparticle
rodent
surfactant
vaccine
animal cell
animal experiment
animal model
animal tissue
Article
CD8+ T lymphocyte
cellular immunity
controlled study
cross protection
cytokine response
drug efficacy
drug safety
drug synthesis
female
human
humoral immunity
hydrophilicity
immune response
immunopathology
immunosurveillance
influenza
innate immunity
lung alveolus epithelium cell
lung alveolus macrophage
mouse
Mustela putorius furo
nanoencapsulation
nonhuman
priority journal
Mus
Mustela