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Plant breeding advancements with CRISPR-Cas genome editing technologies will assist future food security 期刊论文
FRONTIERS IN PLANT SCIENCE, 2023, 卷号: 14
作者:  Ahmad, M.
收藏  |  浏览/下载:1/0  |  提交时间:2024/01/31
Cross-talk of insulin-like peptides, juvenile hormone, and 20-hydroxyecdysone in regulation of metabolism in the mosquito aedes aegypti 期刊论文
Proceedings of the National Academy of Sciences of the United States of America, 2021, 卷号: 118, 期号: 6
作者:  Ling L.;  Raikhel A.S.
收藏  |  浏览/下载:29/0  |  提交时间:2021/05/24
Loss of function of a DMR6 ortholog in tomato confers broad-spectrum disease resistance 期刊论文
Proceedings of the National Academy of Sciences of the United States of America, 2021, 卷号: 118, 期号: 27
作者:  de Toledo Thomazella D.P.;  Seong K.;  Mackelprang R.;  Dahlbeck D.;  Geng Y.;  Gill U.S.;  Qi T.;  Pham J.;  Giuseppe P.;  Lee C.Y.;  Ortega A.;  Cho M.-J.;  Hutton S.F.;  Staskawicz B.
收藏  |  浏览/下载:48/0  |  提交时间:2022/02/22
Gene drive that results in addiction to a temperature-sensitive version of an essential gene triggers population collapse in Drosophila 期刊论文
Proceedings of the National Academy of Sciences of the United States of America, 2021, 卷号: 118, 期号: 49
作者:  Oberhofer G.;  Ivy T.;  Hay B.A.
收藏  |  浏览/下载:21/0  |  提交时间:2022/02/22
Reintroduction of the archaic variant of NOVA1 in cortical organoids alters neurodevelopment 期刊论文
Science, 2021, 卷号: 371, 期号: 6530
作者:  Trujillo C.A.;  Rice E.S.;  Schaefer N.K.;  Chaim I.A.;  Wheeler E.C.;  Madrigal A.A.;  Buchanan J.;  Preissl S.;  Wang A.;  Negraes P.D.;  Szeto R.A.;  Herai R.H.;  Huseynov A.;  Ferraz M.S.A.;  Borges F.S.;  Kihara A.H.;  Byrne A.;  Marin M.;  Vollmers C.;  Brooks A.N.;  Lautz J.D.;  Semendeferi K.;  Shapiro B.;  Yeo G.W.;  Smith S.E.P.;  Green R.E.;  Muotri A.R.
收藏  |  浏览/下载:35/0  |  提交时间:2022/01/14
Knockout of the HMG domain of the porcine SRY gene causes sex reversal in gene-edited pigs 期刊论文
Proceedings of the National Academy of Sciences of the United States of America, 2021, 卷号: 118, 期号: 2
作者:  Kurtz S.;  Lucas-Hahn A.;  Schlegelberger B.;  Göhring G.;  Niemann H.;  Mettenleiter T.C.;  Petersen B.
收藏  |  浏览/下载:37/0  |  提交时间:2021/05/24
Real-time observation of cas9 postcatalytic domain motions 期刊论文
Proceedings of the National Academy of Sciences of the United States of America, 2021, 卷号: 118, 期号: 2
作者:  Wang Y.;  Mallon J.;  Wang H.;  Singh D.;  Jo M.H.;  Hua B.;  Bailey S.;  Ha T.
收藏  |  浏览/下载:31/0  |  提交时间:2021/05/24
Unconstrained genome targeting with near-PAMless engineered CRISPR-Cas9 variants 期刊论文
, 2020, 卷号: 368, 期号: 6488
作者:  Walton R.T.;  Christie K.A.;  Whittaker M.N.;  Kleinstiver B.P.
收藏  |  浏览/下载:16/0  |  提交时间:2020/07/28
adenine  adenosine  CRISPR associated endonuclease Cas9  cytosine  guanosine  SpG protein  SpRY nuclease  thymine  unclassified drug  Cas9 endonuclease Streptococcus pyogenes  bacterium  enzyme activity  genetic engineering  genetic variation  genome  Article  CRISPR-CAS9 system  DNA sequence  enzyme activity  gene editing  gene targeting  genetic variability  human  mutagenesis  nonhuman  priority journal  protein engineering  protein motif  protein structure  protospacer adjacent motif  Streptococcus pyogenes  chemistry  CRISPR Cas system  enzyme specificity  gene editing  gene targeting  genetic predisposition  genetics  HEK293 cell line  procedures  protein domain  Streptococcus pyogenes  CRISPR-Associated Protein 9  CRISPR-Cas Systems  Gene Editing  Gene Targeting  Genetic Predisposition to Disease  HEK293 Cells  Humans  Mutagenesis  Protein Domains  Substrate Specificity  
Very fast CRISPR on demand 期刊论文
, 2020, 卷号: 368, 期号: 6496
作者:  Liu Y.;  Zou R.S.;  He S.;  Nihongaki Y.;  Li X.;  Razavi S.;  Wu B.;  Ha T.
收藏  |  浏览/下载:20/0  |  提交时间:2020/07/28
Cas9 endonuclease Streptococcus pyogenes  double strand break repair protein MRE11  H2AX protein, human  histone  MRE11 protein, human  CRISPR Cas system  DNA cleavage  DNA repair  double stranded DNA break  fluorescence imaging  gene editing  genetics  HEK293 cell line  human  light  metabolism  phosphorylation  procedures  radiation response  single cell analysis  CRISPR-Associated Protein 9  CRISPR-Cas Systems  DNA Breaks, Double-Stranded  DNA Cleavage  DNA Repair  Gene Editing  HEK293 Cells  Histones  Humans  Light  MRE11 Homologue Protein  Optical Imaging  Phosphorylation  Single-Cell Analysis  
Reduced thermal tolerance in a coral carrying CRISPR-induced mutations in the gene for a heat-shock transcription factor 期刊论文
Proceedings of the National Academy of Sciences of the United States of America, 2020, 卷号: 117, 期号: 46
作者:  Cleves P.A.;  Tinoco A.I.;  Bradford J.;  Perrin D.;  Bay L.K.;  Pringle J.R.
收藏  |  浏览/下载:22/0  |  提交时间:2021/01/06