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A phage-encoded anti-CRISPR enables complete evasion of type VI-A CRISPR-Cas immunity 期刊论文
, 2020, 卷号: 369, 期号: 6499
作者:  Meeske A.J.;  Jia N.;  Cassel A.K.;  Kozlova A.;  Liao J.;  Wiedmann M.;  Patel D.J.;  Marraffini L.A.
收藏  |  浏览/下载：30/0  |  提交时间：2020/07/28
CRISPR associated protein  endonuclease  guide RNA  viral protein  virus RNA  bacteriophage  clustered regularly interspaced short palindromic repeat  CRISPR Cas system  DNA cleavage  genetics  Listeria  metabolism  RNA stability  virology  Bacteriophages  Clustered Regularly Interspaced Short Palindromic Repeats  CRISPR-Associated Proteins  CRISPR-Cas Systems  DNA Cleavage  Endonucleases  Listeria  RNA Stability  RNA, Guide  RNA, Viral  Viral Proteins  
Structure of the RNA-dependent RNA polymerase from COVID-19 virus 期刊论文
, 2020, 卷号: 368, 期号: 6492
作者:  Gao Y.;  Yan L.;  Huang Y.;  Liu F.;  Zhao Y.;  Cao L.;  Wang T.;  Sun Q.;  Ming Z.;  Zhang L.;  Ge J.;  Zheng L.;  Zhang Y.;  Wang H.;  Zhu Y.;  Zhu C.;  Hu T.;  Hua T.;  Zhang B.;  Yang X.;  Li J.;  Yang H.;  Liu Z.;  Xu W.;  Guddat L.W.;  Wang Q.;  Lou Z.;  Rao Z.
收藏  |  浏览/下载：38/0  |  提交时间：2020/07/28
comparative study  drug  electron microscopy  enzyme  enzyme activity  RNA  virus  Coronavirus  SARS coronavirus  adenosine phosphate  alanine  antivirus agent  NSP7 protein, SARS-CoV-2  NSP8 protein, SARS-CoV-2  remdesivir  RNA directed RNA polymerase  RNA-dependent RNA polymerase, coronavirus  viral protein  beta sheet  Betacoronavirus  chemistry  cryoelectron microscopy  drug design  enzyme active site  enzymology  metabolism  molecular model  protein domain  ultrastructure  Adenosine Monophosphate  Alanine  Antiviral Agents  Betacoronavirus  Catalytic Domain  Cryoelectron Microscopy  Drug Design  Models, Molecular  Protein Conformation, beta-Strand  Protein Domains  RNA Replicase  Viral Nonstructural Proteins  
Transcription polymerase-catalyzed emergence of novel RNA replicons 期刊论文
, 2020, 卷号: 368, 期号: 6487
作者:  Jain N.;  Blauch L.R.;  Szymanski M.R.;  Das R.;  Tang S.K.Y.;  Yin Y.W.;  Fire A.Z.
收藏  |  浏览/下载：28/0  |  提交时间：2020/07/28
cell component  enzyme  enzyme activity  genetic analysis  RNA  article  bacteriophage  catalysis  DNA replication origin  heredity  in vitro study  nonhuman  plant seed  replicon  RNA replication  synthesis  transcription initiation  biocatalysis  biosynthesis  genetic transcription  metabolism  Animalia  Hepatitis delta virus  Viroids  bacteriophage T7 RNA polymerase  DNA directed RNA polymerase  RNA  viral protein  Biocatalysis  DNA-Directed RNA Polymerases  Replicon  RNA  Transcription, Genetic  Viral Proteins  
Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir 期刊论文
, 2020, 卷号: 368, 期号: 6498
作者:  Yin W.;  Mao C.;  Luan X.;  Shen D.-D.;  Shen Q.;  Su H.;  Wang X.;  Zhou F.;  Zhao W.;  Gao M.;  Chang S.;  Xie Y.-C.;  Tian G.;  Jiang H.-W.;  Tao S.-C.;  Shen J.;  Jiang Y.;  Jiang H.;  Xu Y.;  Zhang S.;  Zhang Y.;  Xu H.E.
收藏  |  浏览/下载：110/0  |  提交时间：2020/07/28
adenosine phosphate  alanine  antivirus agent  enzyme inhibitor  multiprotein complex  NSP7 protein, SARS-CoV-2  NSP8 protein, SARS-CoV-2  remdesivir  RNA directed RNA polymerase  RNA-dependent RNA polymerase, coronavirus  viral protein  virus RNA  Betacoronavirus  chemistry  cryoelectron microscopy  drug effect  enzyme active site  enzymology  metabolism  molecular model  physiology  protein conformation  virus replication  Adenosine Monophosphate  Alanine  Antiviral Agents  Betacoronavirus  Catalytic Domain  Cryoelectron Microscopy  Enzyme Inhibitors  Models, Molecular  Multiprotein Complexes  Protein Conformation  RNA Replicase  RNA, Viral  Viral Nonstructural Proteins  Virus Replication  
Susceptibility of ferrets, cats, dogs, and other domesticated animals to SARS-coronavirus 2 期刊论文
, 2020, 卷号: 368, 期号: 6494
作者:  Shi J.;  Wen Z.;  Zhong G.;  Yang H.;  Wang C.;  Huang B.;  Liu R.;  He X.;  Shuai L.;  Sun Z.;  Zhao Y.;  Liu P.;  Liang L.;  Cui P.;  Wang J.;  Zhang X.;  Guan Y.;  Tan W.;  Wu G.;  Chen H.;  Bu Z.;  Bu Z.
收藏  |  浏览/下载：32/0  |  提交时间：2020/07/28
bat  canid  disease control  disease transmission  felid  global perspective  infectious disease  poultry  severe acute respiratory syndrome  viral disease  virus  China  Hubei  Wuhan  Anas  Animalia  Canis familiaris  Coronavirus  Gallus gallus  Mustela  SARS coronavirus  Suidae  virus antibody  virus RNA  animal  Betacoronavirus  blood  cat  chicken  Coronavirus infection  disease model  disease predisposition  dog  domestic animal  duck  feces  female  immunology  isolation and purification  male  Mustela putorius furo  pandemic  physiology  pig  respiratory system  species difference  virology  virus attachment  virus pneumonia  virus replication  Animals  Animals, Domestic  Antibodies, Viral  Betacoronavirus  Cats  Chickens  Coronavirus Infections  Disease Models, Animal  Disease Susceptibility  Dogs  Ducks  Feces  Female  Ferrets  Male  Pandemics  Pneumonia, Viral  Respiratory System  RNA, Viral  Species Specificity  Sus scrofa  Virus Attachment  Virus Replication  
The integrated stress response: From mechanism to disease 期刊论文
, 2020, 卷号: 368, 期号: 6489
作者:  [无可用作者姓名]
收藏  |  浏览/下载：20/0  |  提交时间：2020/07/28
initiation factor 2  cell component  cognition  disease  homeostasis  protein  quality control  5' untranslated region  adulthood  Article  cell reprogramming technique  cellular stress response  cognitive defect  diabetes mellitus  disease activity  eukaryotic cell  gene expression  human  long term memory  malignant neoplasm  metabolic disorder  nerve degeneration  nonhuman  oxidative stress  pathogenesis  phosphorylation  priority journal  protein defect  protein homeostasis  RNA translation  signal transduction  translation initiation  virus infection  
De novo design of protein logic gates 期刊论文
, 2020, 卷号: 368, 期号: 6486
作者:  Chen Z.;  Kibler R.D.;  Hunt A.;  Busch F.;  Pearl J.;  Jia M.;  VanAernum Z.L.;  Wicky B.I.M.;  Dods G.;  Liao H.;  Wilken M.S.;  Ciarlo C.;  Green S.;  El-Samad H.;  Stamatoyannopoulos J.;  Wysocki V.H.;  Jewett M.C.;  Boyken S.E.;  Baker D.
收藏  |  浏览/下载：22/0  |  提交时间：2020/07/28
cell  design method  gene expression  genetic analysis  protein  activation domain  Article  binding affinity  circular dichroism  controlled study  de novo design  design  DNA binding motif  enzyme activity  genetic transcription  human  human cell  hydrogen bond  hydrophobicity  mass spectrometry  native mass spectrometry  nonhuman  priority journal  protein protein interaction  protein structure  RNA translation  stoichiometry  thermodynamics  two hybrid system  X ray crystallography  chemistry  genetics  logic  metabolism  protein analysis  protein engineering  protein processing  synthetic biology  T lymphocyte  yeast  HAVCR2 protein, human  hepatitis A virus cellular receptor 2  Hepatitis A Virus Cellular Receptor 2  Humans  Logic  Mass Spectrometry  Protein Engineering  Protein Interaction Maps  Protein Processing, Post-Translational  Synthetic Biology  T-Lymphocytes  Transcription, Genetic  Yeasts  
SARS-CoV-2 productively infects human gut enterocytes 期刊论文
, 2020, 卷号: 369, 期号: 6499
作者:  Lamers M.M.;  Beumer J.;  van der Vaart J.;  Knoops K.;  Puschhof J.;  Breugem T.I.;  Ravelli R.B.G.;  Paul van Schayck J.;  Mykytyn A.Z.;  Duimel H.Q.;  van Donselaar E.;  Riesebosch S.;  Kuijpers H.J.H.;  Schipper D.;  van de Wetering W.J.;  de Graaf M.;  Koopmans M.;  Cuppen E.;  Peters P.J.;  Haagmans B.L.;  Clevers H.
收藏  |  浏览/下载：28/0  |  提交时间：2020/07/28
angiotensin converting enzyme 2  dipeptidyl carboxypeptidase  messenger RNA  virus receptor  Betacoronavirus  cell culture technique  cell differentiation  cell lineage  cell proliferation  culture medium  gene expression  genetics  human  ileum  intestine cell  lung  male  metabolism  organoid  physiology  respiratory mucosa  SARS coronavirus  ultrastructure  virology  virus replication  Betacoronavirus  Cell Culture Techniques  Cell Differentiation  Cell Lineage  Cell Proliferation  Culture Media  Enterocytes  Gene Expression  Humans  Ileum  Lung  Male  Organoids  Peptidyl-Dipeptidase A  Receptors, Virus  Respiratory Mucosa  RNA, Messenger  SARS Virus  Virus Replication  
Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved a-ketoamide inhibitors 期刊论文
, 2020, 卷号: 368, 期号: 6489
作者:  Zhang L.;  Lin D.;  Sun X.;  Curth U.;  Drosten C.;  Sauerhering L.;  Becker S.;  Rox K.;  Hilgenfeld R.
收藏  |  浏览/下载：30/0  |  提交时间：2020/07/28
alanine  alpha ketoamide inhibitor  antivirus agent  isoleucine  leucine  proteinase  Severe acute respiratory syndrome coronavirus 2 main protease  threonine  unclassified drug  crystal structure  drug  enzyme  enzyme activity  inhibitor  reaction kinetics  amino acid sequence  animal cell  animal experiment  animal tissue  antiviral activity  Article  catalysis  catalytic efficiency  controlled study  crystal structure  dimerization  dissociation constant  drug clearance  drug design  drug distribution  drug half life  drug potency  drug protein binding  drug solubility  drug structure  EC50  enzyme inhibition  human  human cell  hydrogen bond  hydrophobicity  IC50  maximum concentration  mean residence time  metabolic stability  mouse  nonhuman  priority journal  protein structure  RNA replication  SARS coronavirus  Severe acute respiratory syndrome coronavirus 2  viral tropism  virus inhibition  Coronavirus  SARS coronavirus  
Structural basis for transcriptional start site control of HIV-1 RNA fate 期刊论文
, 2020, 卷号: 368, 期号: 6489
作者:  Brown J.D.;  Kharytonchyk S.;  Chaudry I.;  Iyer A.S.;  Carter H.;  Becker G.;  Desai Y.;  Glang L.;  Choi S.H.;  Singh K.;  Lopresti M.W.;  Orellana M.;  Rodriguez T.;  Oboh U.;  Hijji J.;  Ghinger F.G.;  Stewart K.;  Francis D.;  Edwards B.;  Chen P.;  Case D.A.;  Telesnitsky A.;  Summers M.F.
收藏  |  浏览/下载：27/0  |  提交时间：2020/07/28
capped RNA  initiation factor 4E  messenger RNA  virus RNA  capped RNA  guanosine  initiation factor 4E  messenger RNA  virus RNA  cell  chemical binding  deuterium  genome  human immunodeficiency virus  physiological response  RNA  Article  base pairing  deuteron nuclear magnetic resonance  dimerization  DNA helix  energy transfer  gene control  gene function  gene number  human  Human immunodeficiency virus 1  nonhuman  priority journal  promoter region  RNA probe  RNA structure  RNA transcription  virus replication  5' untranslated region  base pairing  chemistry  DNA base composition  gene expression regulation  genetics  Human immunodeficiency virus 1  metabolism  nuclear magnetic resonance  protein synthesis  transcription initiation site  Eukaryota  Human immunodeficiency virus 1  5' Untranslated Regions  Base Composition  Base Pairing  Eukaryotic Initiation Factor-4E  Gene Expression Regulation, Viral  Guanosine  HIV-1  Humans  Nuclear Magnetic Resonance, Biomolecular  Protein Biosynthesis  RNA Caps  RNA, Messenger  RNA, Viral  Transcription Initiation Site