气候变化领域集成服务门户(CCPortal): SARS-CoV-2 productively infects human gut enterocytes

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DOI	10.1126/science.abc1669
	SARS-CoV-2 productively infects human gut enterocytes
	Lamers M.M.; Beumer J.; van der Vaart J.; Knoops K.; Puschhof J.; Breugem T.I.; Ravelli R.B.G.; Paul van Schayck J.; Mykytyn A.Z.; Duimel H.Q.; van Donselaar E.; Riesebosch S.; Kuijpers H.J.H.; Schipper D.; van de Wetering W.J.; de Graaf M.; Koopmans M.; Cuppen E.; Peters P.J.; Haagmans B.L.; Clevers H.
发表日期	2020
ISSN	10959203
起始页码	50
结束页码	54
卷号	369 期号:6499
英文摘要	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can cause coronavirus disease 2019 (COVID-19), an influenza-like disease that is primarily thought to infect the lungs with transmission through the respiratory route. However, clinical evidence suggests that the intestine may present another viral target organ. Indeed, the SARS-CoV-2 receptor angiotensin-converting enzyme 2 (ACE2) is highly expressed on differentiated enterocytes. In human small intestinal organoids (hSIOs), enterocytes were readily infected by SARS-CoV and SARS-CoV-2, as demonstrated by confocal and electron microscopy. Enterocytes produced infectious viral particles, whereas messenger RNA expression analysis of hSIOs revealed induction of a generic viral response program. Therefore, the intestinal epithelium supports SARS-CoV-2 replication, and hSIOs serve as an experimental model for coronavirus infection and biology. Copyright © 2020, American Association for the Advancement of Science.
关键词	angiotensin converting enzyme 2 dipeptidyl carboxypeptidase messenger RNA virus receptor Betacoronavirus cell culture technique cell differentiation cell lineage cell proliferation culture medium gene expression genetics human ileum intestine cell lung male metabolism organoid physiology respiratory mucosa SARS coronavirus ultrastructure virology virus replication Betacoronavirus Cell Culture Techniques Cell Differentiation Cell Lineage Cell Proliferation Culture Media Enterocytes Gene Expression Humans Ileum Lung Male Organoids Peptidyl-Dipeptidase A Receptors, Virus Respiratory Mucosa RNA, Messenger SARS Virus Virus Replication
语种	英语
来源机构	Science (New York, N.Y.)
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/133370
推荐引用方式 GB/T 7714	Lamers M.M.,Beumer J.,van der Vaart J.,et al. SARS-CoV-2 productively infects human gut enterocytes[J]. Science (New York, N.Y.),2020,369(6499).
APA	Lamers M.M..,Beumer J..,van der Vaart J..,Knoops K..,Puschhof J..,...&Clevers H..(2020).SARS-CoV-2 productively infects human gut enterocytes.,369(6499).
MLA	Lamers M.M.,et al."SARS-CoV-2 productively infects human gut enterocytes".369.6499(2020).