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Comparative pathogenesis of COVID-19, MERS, and SARS in a nonhuman primate model 期刊论文
, 2020, 卷号: 368, 期号: 6494
作者:  Rockx B.;  Kuiken T.;  Herfst S.;  Bestebroer T.;  Lamers M.M.;  Munnink B.B.O.;  De Meulder D.;  Van Amerongen G.;  Van Den Brand J.;  Okba N.M.A.;  Schipper D.;  Van Run P.;  Leijten L.;  Sikkema R.;  Verschoor E.;  Verstrepen B.;  Bogers W.;  Langermans J.;  Langermans J.;  Drosten C.;  Van Vlissingen M.F.;  Fouchier R.;  De Swart R.;  Koopmans M.;  Haagmans B.L.
收藏  |  浏览/下载:21/0  |  提交时间:2020/07/28
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Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved a-ketoamide inhibitors 期刊论文
, 2020, 卷号: 368, 期号: 6489
作者:  Zhang L.;  Lin D.;  Sun X.;  Curth U.;  Drosten C.;  Sauerhering L.;  Becker S.;  Rox K.;  Hilgenfeld R.
收藏  |  浏览/下载:29/0  |  提交时间:2020/07/28
alanine  alpha ketoamide inhibitor  antivirus agent  isoleucine  leucine  proteinase  Severe acute respiratory syndrome coronavirus 2 main protease  threonine  unclassified drug  crystal structure  drug  enzyme  enzyme activity  inhibitor  reaction kinetics  amino acid sequence  animal cell  animal experiment  animal tissue  antiviral activity  Article  catalysis  catalytic efficiency  controlled study  crystal structure  dimerization  dissociation constant  drug clearance  drug design  drug distribution  drug half life  drug potency  drug protein binding  drug solubility  drug structure  EC50  enzyme inhibition  human  human cell  hydrogen bond  hydrophobicity  IC50  maximum concentration  mean residence time  metabolic stability  mouse  nonhuman  priority journal  protein structure  RNA replication  SARS coronavirus  Severe acute respiratory syndrome coronavirus 2  viral tropism  virus inhibition  Coronavirus  SARS coronavirus