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| DOI | 10.1126/science.aat5314 |
| The integrated stress response: From mechanism to disease | |
| [无可用作者姓名] | |
| 发表日期 | 2020 |
| ISSN | 0036-8075 |
| 卷号 | 368期号:6489 |
| 英文摘要 | Protein quality control is essential for the proper function of cells and the organisms that they make up. The resulting loss of proteostasis, the processes by which the health of the cell’s proteins is monitored and maintained at homeostasis, is associated with a wide range of age-related human diseases. Here, we highlight how the integrated stress response (ISR), a central signaling network that responds to proteostasis defects by tuning protein synthesis rates, impedes the formation of long-term memory. In addition, we address how dysregulated ISR signaling contributes to the pathogenesis of complex diseases, including cognitive disorders, neurodegeneration, cancer, diabetes, and metabolic disorders. The development of tools through which the ISR can be modulated promises to uncover new avenues to diminish pathologies resulting from it for clinical benefit. © 2020 American Association for the Advancement of Science. All rights reserved. |
| 关键词 | initiation factor 2cell componentcognitiondiseasehomeostasisproteinquality control5' untranslated regionadulthoodArticlecell reprogramming techniquecellular stress responsecognitive defectdiabetes mellitusdisease activityeukaryotic cellgene expressionhumanlong term memorymalignant neoplasmmetabolic disordernerve degenerationnonhumanoxidative stresspathogenesisphosphorylationpriority journalprotein defectprotein homeostasisRNA translationsignal transductiontranslation initiationvirus infection |
| 语种 | 英语 |
| 来源机构 | Science |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/133538 |
| 推荐引用方式 GB/T 7714 | [无可用作者姓名]. The integrated stress response: From mechanism to disease[J]. Science,2020,368(6489). |
| APA | [无可用作者姓名].(2020).The integrated stress response: From mechanism to disease.,368(6489). |
| MLA | [无可用作者姓名]."The integrated stress response: From mechanism to disease".368.6489(2020). |
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