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Horizontal gene transfer of Fhb7 from fungus underlies Fusarium head blight resistance in wheat
期刊论文
, 2020, 卷号: 368, 期号: 6493
作者:
Wang H.
;
Sun S.
;
Ge W.
;
Zhao L.
;
Hou B.
;
Wang K.
;
Lyu Z.
;
Chen L.
;
Xu S.
;
Guo J.
;
Li M.
;
Su P.
;
Li X.
;
Wang G.
;
Bo C.
;
Fang X.
;
Zhuang W.
;
Cheng X.
;
Wu J.
;
Dong L.
;
Chen W.
;
Li W.
;
Xiao G.
;
Zhao J.
;
Hao Y.
;
Xu Y.
;
Gao Y.
;
Liu W.
;
Liu Y.
;
Yin H.
;
Li J.
;
Li X.
;
Zhao Y.
;
Wang X.
;
Ni F.
;
Ma X.
;
Li A.
;
Xu S.S.
;
Bai G.
;
Nevo E.
;
Gao C.
;
Ohm H.
;
Kong L.
收藏
  |  
浏览/下载:47/0
  |  
提交时间:2020/07/28
fungus
gene transfer
genome
germplasm
toxin
wheat
Fungi
Fusarium
Lophopyrum elongatum
Triticum aestivum
glutathione transferase
disease resistance
Epichloe
Fusarium
genetics
horizontal gene transfer
microbiology
molecular cloning
pathogenicity
plant breeding
plant disease
Poaceae
wheat
Cloning, Molecular
Disease Resistance
Epichloe
Fusarium
Gene Transfer, Horizontal
Glutathione Transferase
Plant Breeding
Plant Diseases
Poaceae
Triticum
Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease
期刊论文
, 2020, 卷号: 368, 期号: 6497
作者:
Dai W.
;
Zhang B.
;
Jiang X.-M.
;
Su H.
;
Li J.
;
Zhao Y.
;
Xie X.
;
Jin Z.
;
Peng J.
;
Liu F.
;
Li C.
;
Li Y.
;
Bai F.
;
Wang H.
;
Cheng X.
;
Cen X.
;
Hu S.
;
Yang X.
;
Wang J.
;
Liu X.
;
Xiao G.
;
Jiang H.
;
Rao Z.
;
Zhang L.-K.
;
Xu Y.
;
Yang H.
;
Liu H.
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2020/07/28
aldehyde
antimicrobial activity
drug
enzyme activity
infectivity
inhibitor
reaction kinetics
viral disease
Coronavirus
SARS coronavirus
3C-like proteinase, Coronavirus
antivirus agent
cysteine proteinase
viral protein
animal
Betacoronavirus
chemical structure
chemistry
Chlorocebus aethiops
Coronavirus infection
dog
drug design
drug effect
enzyme active site
enzymology
female
human
male
mouse
pandemic
preclinical study
protein tertiary structure
Sprague Dawley rat
toxicity testing
Vero cell line
virus pneumonia
Animals
Antiviral Agents
Betacoronavirus
Catalytic Domain
Chlorocebus aethiops
Coronavirus Infections
Cysteine Endopeptidases
Dogs
Drug Design
Drug Evaluation, Preclinical
Female
Humans
Male
Mice
Molecular Structure
Pandemics
Pneumonia, Viral
Protein Structure, Tertiary
Rats, Sprague-Dawley
Toxicity Tests
Vero Cells
Viral Nonstructural Proteins
De novo protein design enables the precise induction of RSV-neutralizing antibodies
期刊论文
, 2020, 卷号: 368, 期号: 6492
作者:
Sesterhenn F.
;
Yang C.
;
Bonet J.
;
Cramer J.T.
;
Wen X.
;
Wang Y.
;
Chiang C.-I.
;
Abriata L.A.
;
Kucharska I.
;
Castoro G.
;
Vollers S.S.
;
Galloux M.
;
Dheilly E.
;
Rosset S.
;
Corthésy P.
;
Georgeon S.
;
Villard M.
;
Richard C.-A.
;
Descamps D.
;
Delgado T.
;
Oricchio E.
;
Rameix-Welti M.-A.
;
Más V.
;
Ervin S.
;
Eléouët J.-F.
;
Riffault S.
;
Bates J.T.
;
Julien J.-P.
;
Li Y.
;
Jardetzky T.
;
Krey T.
;
Correia B.E.
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2020/07/28
algorithm
antibody
design
neutralization
protein
vaccine
Mus
Primates
Respiratory syncytial virus
Rice stripe virus
epitope
fusion protein
nanobody
neutralizing antibody
respiratory syncytial virus vaccine
biology
biosynthesis
chemistry
human
Human respiratory syncytial virus
immunology
procedures
protein conformation
protein engineering
protein motif
Amino Acid Motifs
Antibodies, Neutralizing
Computational Biology
Humans
Immunodominant Epitopes
Protein Conformation
Protein Engineering
Recombinant Fusion Proteins
Respiratory Syncytial Virus Vaccines
Respiratory Syncytial Virus, Human
Single-Domain Antibodies
Very fast CRISPR on demand
期刊论文
, 2020, 卷号: 368, 期号: 6496
作者:
Liu Y.
;
Zou R.S.
;
He S.
;
Nihongaki Y.
;
Li X.
;
Razavi S.
;
Wu B.
;
Ha T.
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2020/07/28
Cas9 endonuclease Streptococcus pyogenes
double strand break repair protein MRE11
H2AX protein, human
histone
MRE11 protein, human
CRISPR Cas system
DNA cleavage
DNA repair
double stranded DNA break
fluorescence imaging
gene editing
genetics
HEK293 cell line
human
light
metabolism
phosphorylation
procedures
radiation response
single cell analysis
CRISPR-Associated Protein 9
CRISPR-Cas Systems
DNA Breaks, Double-Stranded
DNA Cleavage
DNA Repair
Gene Editing
HEK293 Cells
Histones
Humans
Light
MRE11 Homologue Protein
Optical Imaging
Phosphorylation
Single-Cell Analysis
VISTA is a checkpoint regulator for naïve T cell quiescence and peripheral tolerance
期刊论文
, 2020, 卷号: 367, 期号: 6475
作者:
ElTanbouly M.A.
;
Zhao Y.
;
Nowak E.
;
Li J.
;
Schaafsma E.
;
Le Mercier I.
;
Ceeraz S.
;
Lines J.L.
;
Peng C.
;
Carriere C.
;
Huang X.
;
Day M.
;
Koehn B.
;
Lee S.W.
;
Morales M.S.
;
Hogquist K.A.
;
Jameson S.C.
;
Mueller D.
;
Rothstein J.
;
Blazar B.R.
;
Cheng C.
;
Noelle R.J.
收藏
  |  
浏览/下载:40/0
  |  
提交时间:2020/07/28
cell protein
interferon
kruppel like factor 2
T lymphocyte receptor
unclassified drug
V type immunoglobulin domain containing suppressor of T cell activation protein
B7 antigen
Dies1 protein, mouse
lymphocyte antigen receptor
membrane protein
monoclonal antibody
VSIR protein, human
biological development
cell
gene expression
heterogeneity
homeostasis
immune response
immunity
tolerance
acute graft versus host disease
animal cell
animal experiment
animal model
Article
CD4+ T lymphocyte
cell death
cell expansion
cell fate
cell heterogeneity
cell loss
cell survival
controlled study
female
gene
gene deletion
homeostasis
immunological tolerance
in vivo study
long term survival
male
mouse
nonhuman
phenotype
priority journal
protein expression
protein function
rheumatoid arthritis
RNA sequencing
systemic lupus erythematosus
T lymphocyte
T lymphocyte activation
T lymphocyte subpopulation
TCR gene
upregulation
VISTA gene
animal
C57BL mouse
genetics
immunological tolerance
immunology
knockout mouse
lymphocyte activation
physiology
T lymphocyte
Mus
Animals
Antibodies, Monoclonal
B7 Antigens
Lymphocyte Activation
Membrane Proteins
Mice
Mice, Inbred C57BL
Mice, Knockout
Peripheral Tolerance
Receptors, Antigen, T-Cell
T-Lymphocytes
A noncanonical inhibitory circuit dampens behavioral sensitivity to light
期刊论文
, 2020, 卷号: 368, 期号: 6490
作者:
Sonoda T.
;
Li J.Y.
;
Hayes N.W.
;
Chan J.C.
;
Okabe Y.
;
Belin S.
;
Nawabi H.
;
Schmidt T.M.
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2020/07/28
4 aminobutyric acid
cre recombinase
glutamic acid
melanopsin
neurotransmitter
4 aminobutyric acid
4 aminobutyric acid receptor
glutamate decarboxylase
glutamate decarboxylase 2
melanopsin
scotopsin
brain
hormone
inhibition
light effect
nanotechnology
sensitivity analysis
Adeno associated virus
animal cell
Article
axon
brain region
GABAergic system
immunohistochemistry
lateral geniculate body
light
mouse
nonhuman
postsynaptic potential
priority journal
pupil reflex
retina ganglion cell
superior colliculus
suprachiasmatic nucleus
vision
wild type
animal
drug effect
female
light
male
metabolism
mutant mouse strain
nerve tract
physiology
radiation response
retina ganglion cell
vision
Mus
Animals
Female
GABAergic Neurons
gamma-Aminobutyric Acid
Glutamate Decarboxylase
Light
Male
Mice
Mice, Mutant Strains
Neural Pathways
Reflex, Pupillary
Retinal Ganglion Cells
Rod Opsins
Unconscious, Psychology
Visual Perception
Structure of nucleosome-bound human BAF complex
期刊论文
, 2020, 卷号: 367, 期号: 6480
作者:
He S.
;
Wu Z.
;
Tian Y.
;
Yu Z.
;
Yu J.
;
Wang X.
;
Li J.
;
Liu B.
;
Xu Y.
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2020/07/28
actin related protein
adenosine triphosphatase
BRG1 BRM associated factor
DNA
multiprotein complex
protein SWI
retinoblastoma binding protein 2
SMARCC protein
SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily B member 1
transcription factor
transcription factor SNF
unclassified drug
cancer
enzyme activity
gene expression
hydrolysis
mutation
protein
alpha helix
Article
carboxy terminal sequence
cell interaction
cryoelectron microscopy
disease association
human
malignant neoplasm
molecular recognition
mutation
nucleosome
priority journal
protein function
protein hydrolysis
protein structure
structure analysis
Mammalia
A noncompeting pair of human neutralizing antibodies block COVID-19 virus binding to its receptor ACE2
期刊论文
, 2020, 卷号: 368, 期号: 6496
作者:
Wu Y.
;
Wang F.
;
Shen C.
;
Peng W.
;
Li D.
;
Zhao C.
;
Li Z.
;
Li S.
;
Bi Y.
;
Yang Y.
;
Gong Y.
;
Xiao H.
;
Fan Z.
;
Tan S.
;
Wu G.
;
Tan W.
;
Lu X.
;
Fan C.
;
Wang Q.
;
Liu Y.
;
Zhang C.
;
Qi J.
;
Gao G.F.
;
Gao F.
;
Liu L.
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2020/07/28
Coronavirus
angiotensin converting enzyme 2
coronavirus spike glycoprotein
dipeptidyl carboxypeptidase
epitope
monoclonal antibody
neutralizing antibody
virus antibody
virus receptor
animal
chemistry
Coronavirus infection
disease model
human
immunology
isolation and purification
lung
mouse
pandemic
protein domain
serodiagnosis
virology
virus load
virus pneumonia
Animals
Antibodies, Monoclonal
Antibodies, Neutralizing
Antibodies, Viral
Coronavirus Infections
Disease Models, Animal
Humans
Immunodominant Epitopes
Lung
Mice
Neutralization Tests
Pandemics
Peptidyl-Dipeptidase A
Pneumonia, Viral
Protein Domains
Receptors, Virus
Spike Glycoprotein, Coronavirus
Viral Load
Substantial undocumented infection facilitates the rapid dissemination of novel coronavirus (SARS-CoV-2)
期刊论文
, 2020, 卷号: 368, 期号: 6490
作者:
Li R.
;
Pei S.
;
Chen B.
;
Song Y.
;
Zhang T.
;
Yang W.
;
Shaman J.
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2020/07/28
disease prevalence
disease spread
disease transmission
infectious disease
metapopulation
population modeling
viral disease
virus
Article
Bayes theorem
China
conceptual framework
coronavirus disease 2019
data analysis
disease severity
disease transmission
documentation
human
mathematical model
metapopulation
nonhuman
priority journal
Severe acute respiratory syndrome coronavirus 2
travel
validation process
China
Coronavirus
SARS coronavirus
Pulmonary surfactant-biomimetic nanoparticles potentiate heterosubtypic influenza immunity
期刊论文
, 2020, 卷号: 367, 期号: 6480
作者:
Wang J.
;
Li P.
;
Yu Y.
;
Fu Y.
;
Jiang H.
;
Lu M.
;
Sun Z.
;
Jiang S.
;
Lu L.
;
Wu M.X.
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2020/07/28
2',3' cyclic guanosine monophosphate adenosine monophosphate
influenza vaccine
interferon
nanoparticle
pulmonary surfactant biomimetic nanoparticle
purine nucleotide
surfactant protein A
surfactant protein D
unclassified drug
cell
drug resistance
immune response
immunity
induced response
influenza
nanoparticle
rodent
surfactant
vaccine
animal cell
animal experiment
animal model
animal tissue
Article
CD8+ T lymphocyte
cellular immunity
controlled study
cross protection
cytokine response
drug efficacy
drug safety
drug synthesis
female
human
humoral immunity
hydrophilicity
immune response
immunopathology
immunosurveillance
influenza
innate immunity
lung alveolus epithelium cell
lung alveolus macrophage
mouse
Mustela putorius furo
nanoencapsulation
nonhuman
priority journal
Mus
Mustela