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Postinfection treatment with a protease inhibitor increases survival of mice with a fatal SARS-CoV-2 infection 期刊论文
Proceedings of the National Academy of Sciences of the United States of America, 2021, 卷号: 118, 期号: 29
作者:  Dampalla C.S.;  Zheng J.;  Perera K.D.;  Wong L.-Y.R.;  Meyerholz D.K.;  Nguyen H.N.;  Kashipathy M.M.;  Battaile K.P.;  Lovell S.;  Kim Y.;  Perlman S.;  Groutas W.C.;  Chang K.-O.
收藏  |  浏览/下载:28/0  |  提交时间:2021/11/25
Design and proof of concept for targeted phage-based COVID-19 vaccination strategies with a streamlined cold-free supply chain 期刊论文
Proceedings of the National Academy of Sciences of the United States of America, 2021, 卷号: 118, 期号: 30
作者:  Staquicini D.I.;  Tang F.H.F.;  Markosian C.;  Yao V.J.;  Staquicini F.I.;  Dodero-Rojas E.;  Contessoto V.G.;  Davis D.;  O’Brien P.;  Habib N.;  Smith T.L.;  Bruiners N.;  Sidman R.L.;  Gennaro M.L.;  Lattime E.C.;  Libutti S.K.;  Whitford P.C.;  Burley S.K.;  Onuchic J.N.;  Arap W.;  Pasqualini R.
收藏  |  浏览/下载:38/0  |  提交时间:2021/11/25
Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease 期刊论文
, 2020, 卷号: 368, 期号: 6497
作者:  Dai W.;  Zhang B.;  Jiang X.-M.;  Su H.;  Li J.;  Zhao Y.;  Xie X.;  Jin Z.;  Peng J.;  Liu F.;  Li C.;  Li Y.;  Bai F.;  Wang H.;  Cheng X.;  Cen X.;  Hu S.;  Yang X.;  Wang J.;  Liu X.;  Xiao G.;  Jiang H.;  Rao Z.;  Zhang L.-K.;  Xu Y.;  Yang H.;  Liu H.
收藏  |  浏览/下载:36/0  |  提交时间:2020/07/28
aldehyde  antimicrobial activity  drug  enzyme activity  infectivity  inhibitor  reaction kinetics  viral disease  Coronavirus  SARS coronavirus  3C-like proteinase, Coronavirus  antivirus agent  cysteine proteinase  viral protein  animal  Betacoronavirus  chemical structure  chemistry  Chlorocebus aethiops  Coronavirus infection  dog  drug design  drug effect  enzyme active site  enzymology  female  human  male  mouse  pandemic  preclinical study  protein tertiary structure  Sprague Dawley rat  toxicity testing  Vero cell line  virus pneumonia  Animals  Antiviral Agents  Betacoronavirus  Catalytic Domain  Chlorocebus aethiops  Coronavirus Infections  Cysteine Endopeptidases  Dogs  Drug Design  Drug Evaluation, Preclinical  Female  Humans  Male  Mice  Molecular Structure  Pandemics  Pneumonia, Viral  Protein Structure, Tertiary  Rats, Sprague-Dawley  Toxicity Tests  Vero Cells  Viral Nonstructural Proteins  
Human biomarker interpretation: the importance of intra-class correlation coefficients (ICC) and their calculations based on mixed models, ANOVA, and variance estimates 期刊论文
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS, 2018, 卷号: 21, 期号: 3, 页码: 161-180
作者:  Pleil, Joachim D.;  Wallace, M. Ariel Geer;  Stiegel, Matthew A.;  Funk, William E.
收藏  |  浏览/下载:9/0  |  提交时间:2019/05/04
THE SUOMI NPP SCIENCE DATA SEGMENT ATMOSPHERE PRODUCT EVALUATION AND ALGORITHM TEST ELEMENT (PEATE): POST-LAUNCH CONTINUATION 项目
项目编号: NNX13AO09G S03, 资助机构: US-NASA, 2013-2015
负责人:  LIAM E GUMLEY
收藏  |  浏览/下载:1/0  |  提交时间:2019/09/29
Metabolomics in Toxicology and Preclinical Research 期刊论文
ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION, 2013, 卷号: 30, 期号: 2, 页码: 209-225
作者:  Ramirez, Tzutzuy;  Daneshian, Mardas;  Kamp, Hennicke;  Bois, Frederic Y.;  Clench, Malcolm R.;  Coen, Muireann;  Donley, Beth;  Fischer, Steven M.;  Ekman, Drew R.;  Fabian, Eric;  Guillou, Claude;  Heuer, Joachim;  Hogberg, Helena T.;  Jungnickel, Harald;  Keun, Hector C.;  Krennrich, Gerhard;  Krupp, Eckart;  Luch, Andreas;  Noor, Fozia;  Peter, Erik;  Riefke, Bjoern;  Seymour, Mark;  Skinner, Nigel;  Smirnova, Lena;  Verheij, Elwin;  Wagner, Silvia;  Hartung, Thomas;  van Ravenzwaay, Bennard;  Leist, Marcel
收藏  |  浏览/下载:34/0  |  提交时间:2019/05/04
Mutagenic activity in photocopies 期刊论文
Science, 1980, 卷号: 209, 期号: 4460
作者:  Löfroth G.;  Hefner E.;  Alfheim I.;  Møller M.
收藏  |  浏览/下载:1/0  |  提交时间:2022/01/14