气候变化领域集成服务门户(CCPortal): A noncanonical inhibitory circuit dampens behavioral sensitivity to light

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DOI	10.1126/science.aay3152
	A noncanonical inhibitory circuit dampens behavioral sensitivity to light
	Sonoda T.; Li J.Y.; Hayes N.W.; Chan J.C.; Okabe Y.; Belin S.; Nawabi H.; Schmidt T.M.
发表日期	2020
ISSN	0036-8075
起始页码	527
结束页码	531
卷号	368 期号:6490
英文摘要	Retinal ganglion cells (RGCs) drive diverse, light-evoked behaviors that range from conscious visual perception to subconscious, non–image-forming behaviors. It is thought that RGCs primarily drive these functions through the release of the excitatory neurotransmitter glutamate. We identified a subset of melanopsin-expressing intrinsically photosensitive RGCs (ipRGCs) in mice that release the inhibitory neurotransmitter g-aminobutyric acid (GABA) at non–image-forming brain targets. GABA release from ipRGCs dampened the sensitivity of both the pupillary light reflex and circadian photoentrainment, thereby shifting the dynamic range of these behaviors to higher light levels. Our results identify an inhibitory RGC population in the retina and provide a circuit-level mechanism that contributes to the relative insensitivity of non–image-forming behaviors at low light levels. © 2020 American Association for the Advancement of Science. All rights reserved.
关键词	4 aminobutyric acid cre recombinase glutamic acid melanopsin neurotransmitter 4 aminobutyric acid 4 aminobutyric acid receptor glutamate decarboxylase glutamate decarboxylase 2 melanopsin scotopsin brain hormone inhibition light effect nanotechnology sensitivity analysis Adeno associated virus animal cell Article axon brain region GABAergic system immunohistochemistry lateral geniculate body light mouse nonhuman postsynaptic potential priority journal pupil reflex retina ganglion cell superior colliculus suprachiasmatic nucleus vision wild type animal drug effect female light male metabolism mutant mouse strain nerve tract physiology radiation response retina ganglion cell vision Mus Animals Female GABAergic Neurons gamma-Aminobutyric Acid Glutamate Decarboxylase Light Male Mice Mice, Mutant Strains Neural Pathways Reflex, Pupillary Retinal Ganglion Cells Rod Opsins Unconscious, Psychology Visual Perception
语种	英语
来源机构	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/133527
推荐引用方式 GB/T 7714	Sonoda T.,Li J.Y.,Hayes N.W.,et al. A noncanonical inhibitory circuit dampens behavioral sensitivity to light[J]. Science,2020,368(6490).
APA	Sonoda T..,Li J.Y..,Hayes N.W..,Chan J.C..,Okabe Y..,...&Schmidt T.M..(2020).A noncanonical inhibitory circuit dampens behavioral sensitivity to light.,368(6490).
MLA	Sonoda T.,et al."A noncanonical inhibitory circuit dampens behavioral sensitivity to light".368.6490(2020).