气候变化领域集成服务门户(CCPortal): VISTA is a checkpoint regulator for naïve T cell quiescence and peripheral tolerance

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DOI	10.1126/science.aay0524
	VISTA is a checkpoint regulator for naïve T cell quiescence and peripheral tolerance
	ElTanbouly M.A.; Zhao Y.; Nowak E.; Li J.; Schaafsma E.; Le Mercier I.; Ceeraz S.; Lines J.L.; Peng C.; Carriere C.; Huang X.; Day M.; Koehn B.; Lee S.W.; Morales M.S.; Hogquist K.A.; Jameson S.C.; Mueller D.; Rothstein J.; Blazar B.R.; Cheng C.; Noelle R.J.
发表日期	2020
ISSN	0036-8075
卷号	367 期号:6475
英文摘要	Negative checkpoint regulators (NCRs) temper the T cell immune response to self-antigens and limit the development of autoimmunity. Unlike all other NCRs that are expressed on activated T lymphocytes, V-type immunoglobulin domain-containing suppressor of T cell activation (VISTA) is expressed on naïve T cells. We report an unexpected heterogeneity within the naïve T cell compartment in mice, where loss of VISTA disrupted the major quiescent naïve T cell subset and enhanced self-reactivity. Agonistic VISTA engagement increased T cell tolerance by promoting antigen-induced peripheral T cell deletion. Although a critical player in naïve T cell homeostasis, the ability of VISTA to restrain naïve T cell responses was lost under inflammatory conditions. VISTA is therefore a distinctive NCR of naïve T cells that is critical for steady-state maintenance of quiescence and peripheral tolerance. Copyright © 2020 The Authors,
关键词	cell protein interferon kruppel like factor 2 T lymphocyte receptor unclassified drug V type immunoglobulin domain containing suppressor of T cell activation protein B7 antigen Dies1 protein, mouse lymphocyte antigen receptor membrane protein monoclonal antibody VSIR protein, human biological development cell gene expression heterogeneity homeostasis immune response immunity tolerance acute graft versus host disease animal cell animal experiment animal model Article CD4+ T lymphocyte cell death cell expansion cell fate cell heterogeneity cell loss cell survival controlled study female gene gene deletion homeostasis immunological tolerance in vivo study long term survival male mouse nonhuman phenotype priority journal protein expression protein function rheumatoid arthritis RNA sequencing systemic lupus erythematosus T lymphocyte T lymphocyte activation T lymphocyte subpopulation TCR gene upregulation VISTA gene animal C57BL mouse genetics immunological tolerance immunology knockout mouse lymphocyte activation physiology T lymphocyte Mus Animals Antibodies, Monoclonal B7 Antigens Lymphocyte Activation Membrane Proteins Mice Mice, Inbred C57BL Mice, Knockout Peripheral Tolerance Receptors, Antigen, T-Cell T-Lymphocytes
语种	英语
来源机构	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/133780
推荐引用方式 GB/T 7714	ElTanbouly M.A.,Zhao Y.,Nowak E.,et al. VISTA is a checkpoint regulator for naïve T cell quiescence and peripheral tolerance[J]. Science,2020,367(6475).
APA	ElTanbouly M.A..,Zhao Y..,Nowak E..,Li J..,Schaafsma E..,...&Noelle R.J..(2020).VISTA is a checkpoint regulator for naïve T cell quiescence and peripheral tolerance.,367(6475).
MLA	ElTanbouly M.A.,et al."VISTA is a checkpoint regulator for naïve T cell quiescence and peripheral tolerance".367.6475(2020).