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Structure of the RNA-dependent RNA polymerase from COVID-19 virus
期刊论文
, 2020, 卷号: 368, 期号: 6492
作者:
Gao Y.
;
Yan L.
;
Huang Y.
;
Liu F.
;
Zhao Y.
;
Cao L.
;
Wang T.
;
Sun Q.
;
Ming Z.
;
Zhang L.
;
Ge J.
;
Zheng L.
;
Zhang Y.
;
Wang H.
;
Zhu Y.
;
Zhu C.
;
Hu T.
;
Hua T.
;
Zhang B.
;
Yang X.
;
Li J.
;
Yang H.
;
Liu Z.
;
Xu W.
;
Guddat L.W.
;
Wang Q.
;
Lou Z.
;
Rao Z.
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2020/07/28
comparative study
drug
electron microscopy
enzyme
enzyme activity
RNA
virus
Coronavirus
SARS coronavirus
adenosine phosphate
alanine
antivirus agent
NSP7 protein, SARS-CoV-2
NSP8 protein, SARS-CoV-2
remdesivir
RNA directed RNA polymerase
RNA-dependent RNA polymerase, coronavirus
viral protein
beta sheet
Betacoronavirus
chemistry
cryoelectron microscopy
drug design
enzyme active site
enzymology
metabolism
molecular model
protein domain
ultrastructure
Adenosine Monophosphate
Alanine
Antiviral Agents
Betacoronavirus
Catalytic Domain
Cryoelectron Microscopy
Drug Design
Models, Molecular
Protein Conformation, beta-Strand
Protein Domains
RNA Replicase
Viral Nonstructural Proteins
Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir
期刊论文
, 2020, 卷号: 368, 期号: 6498
作者:
Yin W.
;
Mao C.
;
Luan X.
;
Shen D.-D.
;
Shen Q.
;
Su H.
;
Wang X.
;
Zhou F.
;
Zhao W.
;
Gao M.
;
Chang S.
;
Xie Y.-C.
;
Tian G.
;
Jiang H.-W.
;
Tao S.-C.
;
Shen J.
;
Jiang Y.
;
Jiang H.
;
Xu Y.
;
Zhang S.
;
Zhang Y.
;
Xu H.E.
收藏
  |  
浏览/下载:107/0
  |  
提交时间:2020/07/28
adenosine phosphate
alanine
antivirus agent
enzyme inhibitor
multiprotein complex
NSP7 protein, SARS-CoV-2
NSP8 protein, SARS-CoV-2
remdesivir
RNA directed RNA polymerase
RNA-dependent RNA polymerase, coronavirus
viral protein
virus RNA
Betacoronavirus
chemistry
cryoelectron microscopy
drug effect
enzyme active site
enzymology
metabolism
molecular model
physiology
protein conformation
virus replication
Adenosine Monophosphate
Alanine
Antiviral Agents
Betacoronavirus
Catalytic Domain
Cryoelectron Microscopy
Enzyme Inhibitors
Models, Molecular
Multiprotein Complexes
Protein Conformation
RNA Replicase
RNA, Viral
Viral Nonstructural Proteins
Virus Replication
Metabolomics and mass spectrometry imaging reveal channeled de novo purine synthesis in cells
期刊论文
, 2020, 卷号: 368, 期号: 6488
作者:
Pareek V.
;
Tian H.
;
Winograd N.
;
Benkovic S.J.
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2020/07/28
adenosine phosphate
guanosine phosphate
multienzyme complex
nucleotide
purine
purine
purine derivative
cell
experimental study
imaging method
mass spectrometry
metabolism
protein
Article
biochemistry
enzyme assay
gas cluster ion beam secondary ion mass spectrometry
image analysis
mass spectrometry
metabolomics
mitochondrion
molecular imaging
molecular probe
priority journal
purine synthesis
reaction analysis
single cell analysis
biosynthesis
fluorescence imaging
HeLa cell line
human
metabolism
metabolomics
procedures
secondary ion mass spectrometry
HeLa Cells
Humans
Metabolomics
Mitochondria
Multienzyme Complexes
Optical Imaging
Purines
Single-Cell Analysis
Spectrometry, Mass, Secondary Ion
Pulmonary surfactant-biomimetic nanoparticles potentiate heterosubtypic influenza immunity
期刊论文
, 2020, 卷号: 367, 期号: 6480
作者:
Wang J.
;
Li P.
;
Yu Y.
;
Fu Y.
;
Jiang H.
;
Lu M.
;
Sun Z.
;
Jiang S.
;
Lu L.
;
Wu M.X.
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2020/07/28
2',3' cyclic guanosine monophosphate adenosine monophosphate
influenza vaccine
interferon
nanoparticle
pulmonary surfactant biomimetic nanoparticle
purine nucleotide
surfactant protein A
surfactant protein D
unclassified drug
cell
drug resistance
immune response
immunity
induced response
influenza
nanoparticle
rodent
surfactant
vaccine
animal cell
animal experiment
animal model
animal tissue
Article
CD8+ T lymphocyte
cellular immunity
controlled study
cross protection
cytokine response
drug efficacy
drug safety
drug synthesis
female
human
humoral immunity
hydrophilicity
immune response
immunopathology
immunosurveillance
influenza
innate immunity
lung alveolus epithelium cell
lung alveolus macrophage
mouse
Mustela putorius furo
nanoencapsulation
nonhuman
priority journal
Mus
Mustela
An AMPK–caspase-6 axis controls liver damage in nonalcoholic steatohepatitis
期刊论文
, 2020, 卷号: 367, 期号: 6478
作者:
Zhao P.
;
Sun X.
;
Chaggan C.
;
Liao Z.
;
Wong K.I.
;
He F.
;
Singh S.
;
Loomba R.
;
Karin M.
;
Witztum J.L.
;
Saltiel A.R.
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2020/07/28
6,7 dihydro 4 hydroxy 3 (2' hydroxy 1,1' biphenyl 4 yl) 6 oxothieno[2,3 b]pyridine 5 carbonitrile
adenosine phosphate
caspase 3
caspase 6
caspase 7
cytochrome c
hydroxymethylglutaryl coenzyme A reductase kinase
matrix metalloproteinase
apoptosis
cytochrome
enzyme
enzyme activity
inhibition
protein
rodent
AMPK signaling
animal experiment
animal model
animal tissue
apoptosis
Article
C57BL 6 mouse
cell death
controlled study
drug mechanism
enzyme activation
enzyme activity
enzyme inhibition
enzyme phosphorylation
enzyme repression
gene knockout
human
human cell
human tissue
liver cell
liver fibrosis
liver injury
male
mouse
nonalcoholic steatohepatitis
nonhuman
priority journal
protein cleavage
protein secretion
Determination of the melanocortin-4 receptor structure identifies Ca2+ as a cofactor for ligand binding
期刊论文
, 2020, 卷号: 368, 期号: 6489
作者:
Yu J.
;
Gimenez L.E.
;
Hernandez C.C.
;
Wu Y.
;
Wein A.H.
;
Han G.W.
;
McClary K.
;
Mittal S.R.
;
Burdsall K.
;
Stauch B.
;
Wu L.
;
Stevens S.N.
;
Peisley A.
;
Williams S.Y.
;
Chen V.
;
Millhauser G.L.
;
Zhao S.
;
Cone R.D.
;
Stevens R.C.
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2020/07/28
alpha intermedin
calcium ion
cyclic AMP
G protein coupled receptor
heterotrimeric guanine nucleotide binding protein
inwardly rectifying potassium channel
inwardly rectifying potassium channel subunit Kir7.1
melanocortin 4 receptor
n acetyl alpha intermedin[4-10]cyclo[4 norleucine 5 aspartic acid 7 [3 (2 naphthyl)alanine] 10 lysinamide]
unclassified drug
calcium
G protein coupled receptor
intermedin
inwardly rectifying potassium channel
Kir7.1 channel
ligand
melanocortin 4 receptor
n acetyl alpha intermedin[4-10]cyclo[4 norleucine 5 aspartic acid 7 [3 (2 naphthyl)alanine] 10 lysinamide]
protein binding
calcium
chemical binding
homeostasis
hormone
ligand
obesity
peptide
protein
Article
binding affinity
complex formation
crystallization
drug structure
extracellular calcium
human
ligand binding
priority journal
protein structure
receptor blocking
signal transduction
chemistry
genetics
mutation
protein multimerization
protein secondary structure
X ray crystallography
Calcium
Crystallography, X-Ray
Cyclic AMP
Humans
Ligands
Melanocyte-Stimulating Hormones
Mutation
Potassium Channels, Inwardly Rectifying
Protein Binding
Protein Multimerization
Protein Structure, Secondary
Receptor, Melanocortin, Type 4
Receptors, G-Protein-Coupled
Signal Transduction