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| Comparing the predictions of gap model with vegetation and disturbance data in south-eastern Canadian mixed forests 期刊论文
, 2020, 卷号: 455
作者: Elzein T.; Larocque G.R.; Sirois L.; Arseneault D.
  收藏 | 浏览/下载：47/0 | 提交时间：2020/07/28
Cell proliferation Risk assessment Compositional changes Deciduous species Disturbance history Forest simulation Human disturbances Northern white cedar Regeneration strategies Stand development Reforestation anthropogenic effect basal area coniferous tree disturbance ecological modeling forest inventory mixed forest model validation mortality vegetative reproduction Acer Saccharum Data Forests Reforestation Risk Assessment Simulation Thuja Occidentalis Canada Quebec [Canada] Abies balsamea Acer rubrum Acer saccharum Betula pendula Picea glauca Thuja occidentalis |
| Human CNS barrier-forming organoids with cerebrospinal fluid production 期刊论文
, 2020, 卷号: 369, 期号: 6500
作者: Pellegrini L.; Bonfio C.; Chadwick J.; Begum F.; Skehel M.; Lancaster M.A.
收藏 | 浏览/下载：40/0 | 提交时间：2020/07/28
blood brain barrier cell culture technique cerebrospinal fluid choroid plexus gene expression profiling human metabolism organoid physiology protein cerebrospinal fluid level proteomics single cell analysis Blood-Brain Barrier Cell Culture Techniques Cerebrospinal Fluid Cerebrospinal Fluid Proteins Choroid Plexus Gene Expression Profiling Humans Organoids Proteomics Single-Cell Analysis |
| Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease 期刊论文
, 2020, 卷号: 368, 期号: 6497
作者: Dai W.; Zhang B.; Jiang X.-M.; Su H.; Li J.; Zhao Y.; Xie X.; Jin Z.; Peng J.; Liu F.; Li C.; Li Y.; Bai F.; Wang H.; Cheng X.; Cen X.; Hu S.; Yang X.; Wang J.; Liu X.; Xiao G.; Jiang H.; Rao Z.; Zhang L.-K.; Xu Y.; Yang H.; Liu H.
收藏 | 浏览/下载：46/0 | 提交时间：2020/07/28
aldehyde antimicrobial activity drug enzyme activity infectivity inhibitor reaction kinetics viral disease Coronavirus SARS coronavirus 3C-like proteinase, Coronavirus antivirus agent cysteine proteinase viral protein animal Betacoronavirus chemical structure chemistry Chlorocebus aethiops Coronavirus infection dog drug design drug effect enzyme active site enzymology female human male mouse pandemic preclinical study protein tertiary structure Sprague Dawley rat toxicity testing Vero cell line virus pneumonia Animals Antiviral Agents Betacoronavirus Catalytic Domain Chlorocebus aethiops Coronavirus Infections Cysteine Endopeptidases Dogs Drug Design Drug Evaluation, Preclinical Female Humans Male Mice Molecular Structure Pandemics Pneumonia, Viral Protein Structure, Tertiary Rats, Sprague-Dawley Toxicity Tests Vero Cells Viral Nonstructural Proteins |
| Membrane-proximal F-actin restricts local membrane protrusions and directs cell migration 期刊论文
, 2020, 卷号: 368, 期号: 6496
作者: Bisaria A.; Hayer A.; Garbett D.; Cohen D.; Meyer T.
收藏 | 浏览/下载：39/0 | 提交时间：2020/07/28
cell component concentration (composition) membrane polymerization protein actin green fluorescent protein cell membrane cell motion cell polarity cell surface chemistry genetics human metabolism umbilical vein endothelial cell Actins Cell Membrane Cell Movement Cell Polarity Cell Surface Extensions Green Fluorescent Proteins Human Umbilical Vein Endothelial Cells Humans |
| Temporal integration of mitogen history in mother cells controls proliferation of daughter cells 期刊论文
, 2020, 卷号: 368, 期号: 6496
作者: Min M.; Rong Y.; Tian C.; Spencer S.L.
收藏 | 浏览/下载：29/0 | 提交时间：2020/07/28
cyclin D mitogen activated protein kinase kinase mitogenic agent cell cycle G1 phase cell cycle G2 phase cell proliferation genetics human metabolism physiology protein synthesis signal transduction stem cell Cell Proliferation Cyclin D G1 Phase G2 Phase Humans Mitogen-Activated Protein Kinase Kinases Mitogens Protein Biosynthesis Signal Transduction Stem Cells |
| Computing cancer's weak spots 期刊论文
, 2020, 卷号: 368, 期号: 6496
作者: Khamsi R.
收藏 | 浏览/下载：48/0 | 提交时间：2020/07/28
ruxolitinib STAT3 protein antineoplastic agent transcription factor algorithm cancer computer simulation disease treatment drug development medicine Article cancer cell cancer radiotherapy enzyme inhibition gene activity gene expression regulation gene interaction gene mutation gene repression gene targeting human laboratory test malignant neoplasm molecular dynamics nonhuman oncologist priority journal RNA sequencing algorithm genetics mutation neoplasm personalized medicine procedures systems biology Algorithms Antineoplastic Agents Humans Mutation Neoplasms Precision Medicine Systems Biology Transcription Factors |
| Microenvironment mapping via Dexter energy transfer on immune cells 期刊论文
, 2020, 卷号: 367, 期号: 6482
作者: Geri J.B.; Oakley J.V.; Reyes-Robles T.; Wang T.; McCarver S.J.; White C.H.; Rodriguez-Rivera F.P.; Parker D.L.; Hett E.C.; Fadeyi O.O.; Oslund R.C.; MacMillan D.W.C.
收藏 | 浏览/下载：39/0 | 提交时间：2020/07/28
antibody conjugate carbene programmed death 1 ligand 1 methane programmed death 1 ligand 1 antibody catalysis catalyst cell component detection method enzyme enzyme activity protein antigen binding Article cell membrane energy transfer human immunocompetent cell immunological synapse lymphocyte photocatalysis priority journal protein analysis protein protein interaction tumor microenvironment catalysis chemistry energy transfer Jurkat cell line metabolism photochemistry procedures radiation response ultraviolet radiation B7-H1 Antigen Catalysis Cell Membrane Cellular Microenvironment Energy Transfer Humans Jurkat Cells Lymphocytes Methane Photochemical Processes Protein Interaction Mapping Protein Interaction Maps Ultraviolet Rays |
| A neurodevelopmental origin of behavioral individuality in the Drosophila visual system 期刊论文
, 2020, 卷号: 367, 期号: 6482
作者: Linneweber G.A.; Andriatsilavo M.; Dutta S.B.; Bengochea M.; Hellbruegge L.; Liu G.; Ejsmont R.K.; Straw A.D.; Wernet M.; Hiesinger P.R.; Hassan B.A.
收藏 | 浏览/下载：53/0 | 提交时间：2020/07/28
anatomy asymmetry brain genome neurology orientation visual analysis article brain Drosophila melanogaster human experiment individuality nerve cell nonhuman stochastic model visual system walking anatomy and histology animal Drosophila melanogaster genetic variation genetics growth, development and aging nervous system development orientation physiology visual field visual system Drosophila melanogaster Animals Brain Drosophila melanogaster Genetic Variation Individuality Neurogenesis Orientation Visual Fields Visual Pathways |
| Flexible recruitment of memory-based choice representations by the human medial frontal cortex 期刊论文
, 2020, 卷号: 368, 期号: 6498
作者: Minxha J.; Adolphs R.; Fusi S.; Mamelak A.N.; Rutishauser U.
收藏 | 浏览/下载：35/0 | 提交时间：2020/07/28
adult amygdala article decision making electric potential female hippocampus human human experiment information retrieval male medial frontal cortex medial temporal lobe memory nerve cell |
| Unconstrained genome targeting with near-PAMless engineered CRISPR-Cas9 variants 期刊论文
, 2020, 卷号: 368, 期号: 6488
作者: Walton R.T.; Christie K.A.; Whittaker M.N.; Kleinstiver B.P.
收藏 | 浏览/下载：27/0 | 提交时间：2020/07/28
adenine adenosine CRISPR associated endonuclease Cas9 cytosine guanosine SpG protein SpRY nuclease thymine unclassified drug Cas9 endonuclease Streptococcus pyogenes bacterium enzyme activity genetic engineering genetic variation genome Article CRISPR-CAS9 system DNA sequence enzyme activity gene editing gene targeting genetic variability human mutagenesis nonhuman priority journal protein engineering protein motif protein structure protospacer adjacent motif Streptococcus pyogenes chemistry CRISPR Cas system enzyme specificity gene editing gene targeting genetic predisposition genetics HEK293 cell line procedures protein domain Streptococcus pyogenes CRISPR-Associated Protein 9 CRISPR-Cas Systems Gene Editing Gene Targeting Genetic Predisposition to Disease HEK293 Cells Humans Mutagenesis Protein Domains Substrate Specificity |
