气候变化领域集成服务门户(CCPortal): Flexible recruitment of memory-based choice representations by the human medial frontal cortex

CCPortal

DOI	10.1126/science.aba3313
	Flexible recruitment of memory-based choice representations by the human medial frontal cortex
	Minxha J.; Adolphs R.; Fusi S.; Mamelak A.N.; Rutishauser U.
发表日期	2020
ISSN	10959203
卷号	368 期号:6498
英文摘要	Decision-making in complex environments relies on flexibly using prior experience. This process depends on the medial frontal cortex (MFC) and the medial temporal lobe, but it remains unknown how these structures implement selective memory retrieval. We recorded single neurons in the MFC, amygdala, and hippocampus while human subjects switched between making recognition memory-based and categorization-based decisions. The MFC rapidly implemented changing task demands by using different subspaces of neural activity and by representing the currently relevant task goal. Choices requiring memory retrieval selectively engaged phase-locking of MFC neurons to amygdala and hippocampus field potentials, thereby enabling the routing of memories. These findings reveal a mechanism for flexibly and selectively engaging memory retrieval and show that memory-based choices are preferentially represented in the frontal cortex when required. Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
关键词	adult amygdala article decision making electric potential female hippocampus human human experiment information retrieval male medial frontal cortex medial temporal lobe memory nerve cell
语种	英语
来源机构	Science (New York, N.Y.)
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/133399
推荐引用方式 GB/T 7714	Minxha J.,Adolphs R.,Fusi S.,et al. Flexible recruitment of memory-based choice representations by the human medial frontal cortex[J]. Science (New York, N.Y.),2020,368(6498).
APA	Minxha J.,Adolphs R.,Fusi S.,Mamelak A.N.,&Rutishauser U..(2020).Flexible recruitment of memory-based choice representations by the human medial frontal cortex.,368(6498).
MLA	Minxha J.,et al."Flexible recruitment of memory-based choice representations by the human medial frontal cortex".368.6498(2020).