气候变化领域集成服务门户(CCPortal): Temporal integration of mitogen history in mother cells controls proliferation of daughter cells

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DOI	10.1126/science.aay8241
	Temporal integration of mitogen history in mother cells controls proliferation of daughter cells
	Min M.; Rong Y.; Tian C.; Spencer S.L.
发表日期	2020
ISSN	0036-8075
起始页码	1261
结束页码	1265
卷号	368 期号:6496
英文摘要	Multicellular organisms use mitogens to regulate cell proliferation, but how fluctuating mitogenic signals are converted into proliferation-quiescence decisions is poorly understood. In this work, we combined live-cell imaging with temporally controlled perturbations to determine the time scale and mechanisms underlying this system in human cells. Contrary to the textbook model that cells sense mitogen availability only in the G1 cell cycle phase, we find that mitogenic signaling is temporally integrated throughout the entire mother cell cycle and that even a 1-hour lapse in mitogen signaling can influence cell proliferation more than 12 hours later. Protein translation rates serve as the integrator that proportionally converts mitogen history into corresponding levels of cyclin D in the G2 phase of the mother cell, which controls the proliferation-quiescence decision in daughter cells and thereby couples protein production with cell proliferation. © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
关键词	cyclin D mitogen activated protein kinase kinase mitogenic agent cell cycle G1 phase cell cycle G2 phase cell proliferation genetics human metabolism physiology protein synthesis signal transduction stem cell Cell Proliferation Cyclin D G1 Phase G2 Phase Humans Mitogen-Activated Protein Kinase Kinases Mitogens Protein Biosynthesis Signal Transduction Stem Cells
语种	英语
来源机构	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/133430
推荐引用方式 GB/T 7714	Min M.,Rong Y.,Tian C.,et al. Temporal integration of mitogen history in mother cells controls proliferation of daughter cells[J]. Science,2020,368(6496).
APA	Min M.,Rong Y.,Tian C.,&Spencer S.L..(2020).Temporal integration of mitogen history in mother cells controls proliferation of daughter cells.,368(6496).
MLA	Min M.,et al."Temporal integration of mitogen history in mother cells controls proliferation of daughter cells".368.6496(2020).