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CFLIPL protects macrophages from LPS-induced pyroptosis via inhibition of complex II formation 期刊论文
, 2020, 卷号: 367, 期号: 6484
作者:  Muendlein H.I.;  Jetton D.;  Connolly W.M.;  Eidell K.P.;  Magri Z.;  Smirnova I.;  Poltorak A.
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FLICE inhibitory protein  interleukin 1beta  lipopolysaccharide  messenger RNA  succinate dehydrogenase (ubiquinone)  Casp1 protein, mouse  caspase 8  Cflar protein, mouse  cryopyrin  FLICE inhibitory protein  IL1B protein, mouse  inflammasome  interleukin 1beta  interleukin 1beta converting enzyme  lipopolysaccharide  succinate dehydrogenase (ubiquinone)  cell  enzyme activity  inhibition  maturation  protein  animal cell  animal experiment  Article  bone marrow derived macrophage  cell death  cell protection  complex formation  controlled study  cytokine release  in vitro study  inflammation  mouse  nonhuman  priority journal  protein analysis  protein degradation  protein function  protein interaction  pyroptosis  animal  gene knockdown  genetics  immunology  macrophage  macrophage activation  metabolism  physiology  Murinae  Animals  CASP8 and FADD-Like Apoptosis Regulating Protein  Caspase 1  Caspase 8  Electron Transport Complex II  Gene Knockdown Techniques  Inflammasomes  Interleukin-1beta  Lipopolysaccharides  Macrophage Activation  Macrophages  Mice  NLR Family, Pyrin Domain-Containing 3 Protein  Pyroptosis  
Circadian rhythms in the absence of the clock gene Bmal1 期刊论文
, 2020, 卷号: 367, 期号: 6479
作者:  Ray S.;  Valekunja U.K.;  Stangherlin A.;  Howell S.A.;  Snijders A.P.;  Damodaran G.;  Reddy A.B.
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phosphoproteome  proteome  transcription factor ARNTL  transcription factor Ets  transcriptome  unclassified drug  cell component  circadian rhythm  gene  gene expression  genome  molecular analysis  animal experiment  animal tissue  Article  Bmal1 gene  circadian rhythm  controlled study  gene deletion  gene expression regulation  gene function  gene knockout  genotype  knockout mouse  light dark cycle  liver  mouse  nonhuman  oscillation  oxidation reduction potential  priority journal  RNA sequence  skin fibroblast  temperature  transcription regulation  Mammalia  Mus  
The genetic architecture of the human cerebral cortex 期刊论文
, 2020, 卷号: 367, 期号: 6484
作者:  Grasby K.L.;  Jahanshad N.;  Painter J.N.;  Colodro-Conde L.;  Bralten J.;  Hibar D.P.;  Lind P.A.;  Pizzagalli F.;  Ching C.R.K.;  McMahon M.A.B.;  Shatokhina N.;  Zsembik L.C.P.;  Thomopoulos S.I.;  Zhu A.H.;  Strike L.T.;  Agartz I.;  Alhusaini S.;  Almeida M.A.A.;  Alnæs D.;  Amlien I.K.;  Andersson M.;  Ard T.;  Armstrong N.J.;  Ashley-Koch A.;  Atkins J.R.;  Bernard M.;  Brouwer R.M.;  Buimer E.E.L.;  Bülow R.;  Bürger C.;  Cannon D.M.;  Chakravarty M.;  Chen Q.;  Cheung J.W.;  Couvy-Duchesne B.;  Dale A.M.;  Dalvie S.;  de Araujo T.K.;  de Zubicaray G.I.;  de Zwarte S.M.C.;  den Braber A.;  Doan N.T.;  Dohm K.;  Ehrlich S.;  Engelbrecht H.-R.;  Erk S.;  Fan C.C.;  Fedko I.O.;  Foley S.F.;  Ford J.M.;  Fukunaga M.;  Garrett M.E.;  Ge T.;  Giddaluru S.;  Goldman A.L.;  Green M.J.;  Groenewold N.A.;  Grotegerd D.;  Gurholt T.P.;  Gutman B.A.;  Hansell N.K.;  Harris M.A.;  Harrison M.B.;  Haswell C.C.;  Hauser M.;  Herms S.;  Heslenfeld D.J.;  Ho N.F.;  Hoehn D.;  Hoffmann P.;  Holleran L.;  Hoogman M.;  Hottenga J.-J.;  Ikeda M.;  Janowitz D.;  Jansen I.E.;  Jia T.;  Jockwitz C.;  Kanai R.;  Karama S.;  Kasperaviciute D.;  Kaufmann T.;  Kelly S.;  Kikuchi M.;  Klein M.;  Knapp M.;  Knodt A.R.;  Krämer B.;  Lam M.;  Lancaster T.M.;  Lee P.H.;  Lett T.A.;  Lewis L.B.;  Lopes-Cendes I.;  Luciano M.;  Macciardi F.;  Marquand A.F.;  Mathias S.R.;  Melzer T.R.;  Milaneschi Y.;  Mirza-Schreiber N.;  Moreira J.C.V.;  Mühleisen T.W.;  Müller-Myhsok B.;  Najt P.;  Nakahara S.;  Nho K.;  Olde Loohuis L.M.;  Orfanos D.P.;  Pearson J.F.;  Pitcher T.L.;  Pütz B.;  Quidé Y.;  Ragothaman A.;  Rashid F.M.;  Reay W.R.;  Redlich R.;  Reinbold C.S.;  Repple J.;  Richard G.;  Riedel B.C.;  Risacher S.L.;  Rocha C.S.;  Mota N.R.;  Salminen L.;  Saremi A.;  Saykin A.J.;  Schlag F.;  Schmaal L.;  Schofield P.R.;  Secolin R.;  Shapland C.Y.;  Shen L.;  Shin J.;  Shumskaya E.;  Sønderby I.E.;  Sprooten E.;  Tansey K.E.;  Teumer A.;  Thalamuthu A.;  Tordesillas-Gutiérrez D.;  Turner J.A.;  Uhlmann A.;  Vallerga C.L.;  van der Meer D.;  van Donkelaar M.M.J.;  van Eijk L.;  van Erp T.G.M.;  van Haren N.E.M.;  van Rooij D.;  van Tol M.-J.;  Veldink J.H.;  Verhoef E.;  Walton E.;  Wang M.;  Wang Y.;  Wardlaw J.M.;  Wen W.;  Westlye L.T.;  Whelan C.D.;  Witt S.H.;  Wittfeld K.;  Wolf C.;  Wolfers T.;  Wu J.Q.;  Yasuda C.L.;  Zaremba D.;  Zhang Z.;  Zwiers M.P.;  Artiges E.;  Assareh A.A.;  Ayesa-Arriola R.;  Belger A.;  Brandt C.L.;  Brown G.G.;  Cichon S.;  Curran J.E.;  Davies G.E.;  Degenhardt F.;  Dennis M.F.;  Dietsche B.;  Djurovic S.;  Doherty C.P.;  Espiritu R.;  Garijo D.;  Gil Y.;  Gowland P.A.;  Green R.C.;  Häusler A.N.;  Heindel W.;  Ho B.-C.;  Hoffmann W.U.;  Holsboer F.;  Homuth G.;  Hosten N.;  Jack C.R.;  Jang M.;  Jansen A.;  Kimbrel N.A.;  Kolskår K.;  Koops S.;  Krug A.;  Lim K.O.;  Luykx J.J.;  Mathalon D.H.;  Mather K.A.;  Mattay V.S.;  Matthews S.;  van Son J.M.;  McEwen S.C.;  Melle I.;  Morris D.W.;  Mueller B.A.;  Nauck M.;  Nordvik J.E.;  Nöthen M.M.;  O'Leary D.S.;  Opel N.;  Martinot M.-L.P.;  Bruce Pike G.;  Preda A.;  Quinlan E.B.;  Rasser P.E.;  Ratnakar V.;  Reppermund S.;  Steen V.M.;  Tooney P.A.;  Torres F.R.;  Veltman D.J.;  Voyvodic J.T.;  Whelan R.;  White T.;  Yamamori H.;  Adams H.H.H.;  Bis J.C.;  Debette S.;  Decarli C.;  Fornage M.;  Gudnason V.;  Hofer E.;  Arfan Ikram M.;  Launer L.;  Longstreth W.T.;  Lopez O.L.;  Mazoyer B.;  Mosley T.H.;  Roshchupkin G.V.;  Satizabal C.L.;  Schmidt R.;  Seshadri S.;  Yang Q.;  Alvim M.K.M.;  Ames D.;  Anderson T.J.;  Andreassen O.A.;  Arias-Vasquez A.;  Bastin M.E.;  Baune B.T.;  Beckham J.C.;  Blangero J.;  Boomsma D.I.;  Brodaty H.;  Brunner H.G.;  Buckner R.L.;  Buitelaar J.K.;  Bustillo J.R.;  Cahn W.;  Cairns M.J.;  Calhoun V.;  Carr V.J.;  Caseras X.;  Caspers S.;  Cavalleri G.L.;  Cendes F.;  Corvin A.;  Crespo-Facorro B.;  Dalrymple-Alford J.C.;  Dannlowski U.;  de Geus E.J.C.;  Deary I.J.;  Delanty N.;  Depondt C.;  Desrivières S.;  Donohoe G.;  Espeseth T.;  Fernández G.;  Fisher S.E.;  Flor H.;  Forstner A.J.;  Francks C.;  Franke B.;  Glahn D.C.;  Gollub R.L.;  Grabe H.J.;  Gruber O.;  Håberg A.K.;  Hariri A.R.;  Hartman C.A.;  Hashimoto R.;  Heinz A.;  Henskens F.A.;  Hillegers M.H.J.;  Hoekstra P.J.;  Holmes A.J.;  Elliot Hong L.;  Hopkins W.D.;  Hulshoff Pol H.E.;  Jernigan T.L.;  Jönsson E.G.;  Kahn R.S.;  Kennedy M.A.;  Kircher T.T.J.;  Kochunov P.;  Kwok J.B.J.;  Le Hellard S.;  Loughland C.M.;  Martin N.G.;  Martinot J.-L.;  McDonald C.;  McMahon K.L.;  Meyer-Lindenberg A.;  Michie P.T.;  Morey R.A.;  Mowry B.;  Nyberg L.;  Oosterlaan J.;  Ophoff R.A.;  Pantelis C.;  Paus T.;  Pausova Z.;  Penninx B.W.J.H.;  Polderman T.J.C.;  Posthuma D.;  Rietschel M.;  Roffman J.L.;  Rowland L.M.;  Sachdev P.S.;  Sämann P.G.;  Schall U.;  Schumann G.;  Scott R.J.;  Sim K.;  Sisodiya S.M.;  Smoller J.W.;  Sommer I.E.;  Pourcain B.S.;  Stein D.J.;  Toga A.W.;  Trollor J.N.;  van der Wee N.J.A.;  van't Ent D.;  Völzke H.;  Walter H.;  Weber B.;  Weinberger D.R.;  Wright M.J.;  Zhou J.;  Stein J.L.;  Thompson P.M.;  Medland S.E.;  Enhancing NeuroImaging Genetics through Meta-Analysis Consortium (ENIGMA)-Genetics working group
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brain  genetic analysis  meta-analysis  resonance  signaling  surface area  Article  bioinformatics  brain cortex  brain function  brain region  brain tissue  cortical thickness (brain)  educational status  evidence based medicine  gene control  gene locus  genetic association  genetic correlation  genetic variability  genome-wide association study  human  human genetics  priority journal  surface area  tissue structure  Wnt signaling  anatomy and histology  attention deficit disorder  brain cortex  brain mapping  cognition  genetic variation  genetics  meta analysis  nuclear magnetic resonance imaging  organ size  Parkinson disease  Attention Deficit Disorder with Hyperactivity  Brain Mapping  Cerebral Cortex  Cognition  Genetic Loci  Genetic Variation  Genome-Wide Association Study  Humans  Magnetic Resonance Imaging  Organ Size  Parkinson Disease  
Structural basis of Gs and Gi recognition by the human glucagon receptor 期刊论文
, 2020, 卷号: 367, 期号: 6484
作者:  Qiao A.;  Han S.;  Li X.;  Li Z.;  Zhao P.;  Dai A.;  Chang R.;  Tai L.;  Tan Q.;  Chu X.;  Ma L.;  Thorsen T.S.;  Reedtz-Runge S.;  Yang D.;  Wang M.-W.;  Sexton P.M.;  Wootten D.;  Sun F.;  Zhao Q.;  Wu B.
收藏  |  浏览/下载：43/0  |  提交时间：2020/07/28
cyclic AMP  glucagon  glucagon receptor  inhibitory guanine nucleotide binding protein  stimulatory guanine nucleotide binding protein  glucagon receptor  inhibitory guanine nucleotide binding protein  protein binding  stimulatory guanine nucleotide binding protein  chemical binding  enzyme activity  gene expression  mutagenicity  protein  alpha helix  Article  binding affinity  carboxy terminal sequence  conformational transition  cryoelectron microscopy  human  molecular recognition  mutagenesis  priority journal  protein binding  protein function  protein protein interaction  protein structure  signal transduction  binding site  chemistry  metabolism  molecular model  protein conformation  ultrastructure  Binding Sites  Cryoelectron Microscopy  Glucagon  GTP-Binding Protein alpha Subunits, Gi-Go  GTP-Binding Protein alpha Subunits, Gs  Humans  Models, Molecular  Protein Binding  Protein Conformation  Protein Conformation, alpha-Helical  Receptors, Glucagon  Signal Transduction  
Dopaminylation of histone H3 in ventral tegmental area regulates cocaine seeking 期刊论文
, 2020, 卷号: 368, 期号: 6487
作者:  Lepack A.E.;  Werner C.T.;  Stewart A.F.;  Fulton S.L.;  Zhong P.;  Farrelly L.A.;  Smith A.C.W.;  Ramakrishnan A.;  Lyu Y.;  Bastle R.M.;  Martin J.A.;  Mitra S.;  O'Connor R.M.;  Wang Z.-J.;  Molina H.;  Turecki G.;  Shen L.;  Yan Z.;  Calipari E.S.;  Dietz D.M.;  Kenny P.J.;  Maze I.
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amidase  dopamine  histone H3  histone transamidase  protein glutamine gamma glutamyltransferase 2  RNA  unclassified drug  brain  cell  chemical compound  chemical reaction  gene expression  genetic analysis  protein  action potential  amino acid substitution  amino terminal sequence  Article  cocaine dependence  controlled study  dopamine release  dopaminergic nerve cell  dopaminergic transmission  down regulation  drug seeking behavior  enzyme activity  gene expression  histone dopaminylation  histone modification  human  human tissue  hyperpolarization  in vitro study  motivation  nerve cell plasticity  nerve projection  neuropathology  nucleus accumbens  priority journal  protein expression  protein function  reward  RNA sequence  ventral tegmentum  Rattus  
VISTA is a checkpoint regulator for naïve T cell quiescence and peripheral tolerance 期刊论文
, 2020, 卷号: 367, 期号: 6475
作者:  ElTanbouly M.A.;  Zhao Y.;  Nowak E.;  Li J.;  Schaafsma E.;  Le Mercier I.;  Ceeraz S.;  Lines J.L.;  Peng C.;  Carriere C.;  Huang X.;  Day M.;  Koehn B.;  Lee S.W.;  Morales M.S.;  Hogquist K.A.;  Jameson S.C.;  Mueller D.;  Rothstein J.;  Blazar B.R.;  Cheng C.;  Noelle R.J.
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cell protein  interferon  kruppel like factor 2  T lymphocyte receptor  unclassified drug  V type immunoglobulin domain containing suppressor of T cell activation protein  B7 antigen  Dies1 protein, mouse  lymphocyte antigen receptor  membrane protein  monoclonal antibody  VSIR protein, human  biological development  cell  gene expression  heterogeneity  homeostasis  immune response  immunity  tolerance  acute graft versus host disease  animal cell  animal experiment  animal model  Article  CD4+ T lymphocyte  cell death  cell expansion  cell fate  cell heterogeneity  cell loss  cell survival  controlled study  female  gene  gene deletion  homeostasis  immunological tolerance  in vivo study  long term survival  male  mouse  nonhuman  phenotype  priority journal  protein expression  protein function  rheumatoid arthritis  RNA sequencing  systemic lupus erythematosus  T lymphocyte  T lymphocyte activation  T lymphocyte subpopulation  TCR gene  upregulation  VISTA gene  animal  C57BL mouse  genetics  immunological tolerance  immunology  knockout mouse  lymphocyte activation  physiology  T lymphocyte  Mus  Animals  Antibodies, Monoclonal  B7 Antigens  Lymphocyte Activation  Membrane Proteins  Mice  Mice, Inbred C57BL  Mice, Knockout  Peripheral Tolerance  Receptors, Antigen, T-Cell  T-Lymphocytes  
Peptide signaling for drought-induced tomato flower drop 期刊论文
, 2020, 卷号: 367, 期号: 6485
作者:  Reichardt S.;  Piepho H.-P.;  Stintzi A.;  Schaller A.
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mitogen activated protein kinase  peptide hormone  phytaspase 2  phytosulfokine  unclassified drug  abscission  aspartic acid  crop yield  drought stress  enzyme activity  flower  fruit  gene expression  hormone  peptide  abscission  Arabidopsis  Article  bioassay  cell separation  controlled study  cytokine production  down regulation  drought  environmental stress  enzyme activity  enzyme specificity  ERF4 gene  ERT10 gene  flower  hydrolysis  hydrophobicity  IAA3 gene  immunomodulation  molecular dynamics  nonhuman  peptide signaling  PK7 gene  plant development  plant genome  priority journal  productivity  protein cleavage  protein degradation  protein expression  protein function  protein processing  regulator gene  signal transduction  tomato  TPRP gene  Lycopersicon esculentum  
Structure of nucleosome-bound human BAF complex 期刊论文
, 2020, 卷号: 367, 期号: 6480
作者:  He S.;  Wu Z.;  Tian Y.;  Yu Z.;  Yu J.;  Wang X.;  Li J.;  Liu B.;  Xu Y.
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actin related protein  adenosine triphosphatase  BRG1 BRM associated factor  DNA  multiprotein complex  protein SWI  retinoblastoma binding protein 2  SMARCC protein  SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily B member 1  transcription factor  transcription factor SNF  unclassified drug  cancer  enzyme activity  gene expression  hydrolysis  mutation  protein  alpha helix  Article  carboxy terminal sequence  cell interaction  cryoelectron microscopy  disease association  human  malignant neoplasm  molecular recognition  mutation  nucleosome  priority journal  protein function  protein hydrolysis  protein structure  structure analysis  Mammalia  
Massively multiplex chemical transcriptomics at single-cell resolution 期刊论文
, 2020, 卷号: 367, 期号: 6473
作者:  Srivatsan S.R.;  McFaline-Figueroa J.L.;  Ramani V.;  Saunders L.;  Cao J.;  Packer J.;  Pliner H.A.;  Jackson D.L.;  Daza R.M.;  Christiansen L.;  Zhang F.;  Steemers F.;  Shendure J.;  Trapnell C.
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4 (2 aminoethylamino) 1,8 dimethylimidazo[1,2 a]quinoxaline  abexinostat  acetic acid  belinostat  cudc 101  fimepinostat  givinostat  histone deacetylase inhibitor  m 344  n [2 [3 (1 piperazinylmethyl)imidazo[2,1 b]thiazol 6 yl]phenyl] 2 quinoxalinecarboxamide  panobinostat  pracinostat  rec 2282  trametinib  transcriptome  trichostatin A  unclassified drug  transcriptome  cancer  cell  chemical analysis  detection method  experimental study  genetic analysis  resolution  A-549 cell line  animal cell  animal experiment  Article  cell function  cell heterogeneity  cell labeling  cell proliferation  chromatin  controlled study  dose response  drug activity  experimentation  gene control  genetic transcription  human  human cell  K-562 cell line  MCF-7 cell line  mouse  nonhuman  pilot study  priority journal  proof of concept  RNA sequence  screening  single cell analysis  transcriptomics  cell nucleus  drug effect  genetics  genomics  high throughput screening  metabolism  neoplasm  procedures  single cell analysis  A549 Cells  Acetates  Cell Nucleus  Chromatin  Genomics  High-Throughput Screening Assays  Histone Deacetylase Inhibitors  Humans  K562 Cells  MCF-7 Cells  Neoplasms  RNA-Seq  Single-Cell Analysis  Transcriptome  
Vertebrate diapause preserves organisms long term through Polycomb complex members 期刊论文
, 2020, 卷号: 367, 期号: 6480
作者:  Hu C.-K.;  Wang W.;  Brind'Amour J.;  Singh P.P.;  Adam Reeves G.;  Lorincz M.C.;  Alvarado A.S.;  Brunet A.
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polycomb group protein  protein CBX7  transcriptome  unclassified drug  diapause  gene expression  metabolism  muscle  vertebrate  Article  chromatin  complex formation  developmental gene  diapause  down regulation  embryo development  fertility  gene  gene expression regulation  gene repression  genetic regulation  growth rate  lifespan  lipid metabolism  metabolism  muscle atrophy  muscle gene  neuromuscular junction  nonhuman  priority journal  protein function  tissue preservation  upregulation  vertebrate  Cyprinodontoidei  Nothobranchius furzeri  Vertebrata