气候变化领域集成服务门户(CCPortal): Vertebrate diapause preserves organisms long term through Polycomb complex members

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DOI	10.1126/science.aaw2601
	Vertebrate diapause preserves organisms long term through Polycomb complex members
	Hu C.-K.; Wang W.; Brind'Amour J.; Singh P.P.; Adam Reeves G.; Lorincz M.C.; Alvarado A.S.; Brunet A.
发表日期	2020
ISSN	0036-8075
起始页码	870
结束页码	874
卷号	367 期号:6480
英文摘要	Diapause is a state of suspended development that helps organisms survive extreme environments. How diapause protects living organisms is largely unknown. Using the African turquoise killifish (Nothobranchius furzeri), we show that diapause preserves complex organisms for extremely long periods of time without trade-offs for subsequent adult growth, fertility, and life span. Transcriptome analyses indicate that diapause is an active state, with dynamic regulation of metabolism and organ development genes. The most up-regulated genes in diapause include Polycomb complex members. The chromatin mark regulated by Polycomb, H3K27me3, is maintained at key developmental genes in diapause, and the Polycomb member CBX7 mediates repression of metabolism and muscle genes in diapause. CBX7 is functionally required for muscle preservation and diapause maintenance. Thus, vertebrate diapause is a state of suspended life that is actively maintained by specific chromatin regulators, and this has implications for long-term organism preservation. © 2020 American Association for the Advancement of Science. All rights reserved.
关键词	polycomb group protein protein CBX7 transcriptome unclassified drug diapause gene expression metabolism muscle vertebrate Article chromatin complex formation developmental gene diapause down regulation embryo development fertility gene gene expression regulation gene repression genetic regulation growth rate lifespan lipid metabolism metabolism muscle atrophy muscle gene neuromuscular junction nonhuman priority journal protein function tissue preservation upregulation vertebrate Cyprinodontoidei Nothobranchius furzeri Vertebrata
语种	英语
来源机构	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/133695
推荐引用方式 GB/T 7714	Hu C.-K.,Wang W.,Brind'Amour J.,et al. Vertebrate diapause preserves organisms long term through Polycomb complex members[J]. Science,2020,367(6480).
APA	Hu C.-K..,Wang W..,Brind'Amour J..,Singh P.P..,Adam Reeves G..,...&Brunet A..(2020).Vertebrate diapause preserves organisms long term through Polycomb complex members.,367(6480).
MLA	Hu C.-K.,et al."Vertebrate diapause preserves organisms long term through Polycomb complex members".367.6480(2020).