气候变化领域集成服务门户(CCPortal): Circadian rhythms in the absence of the clock gene Bmal1

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DOI	10.1126/science.aaw7365
	Circadian rhythms in the absence of the clock gene Bmal1
	Ray S.; Valekunja U.K.; Stangherlin A.; Howell S.A.; Snijders A.P.; Damodaran G.; Reddy A.B.
发表日期	2020
ISSN	0036-8075
起始页码	800
结束页码	806
卷号	367 期号:6479
英文摘要	Circadian (~24 hour) clocks have a fundamental role in regulating daily physiology. The transcription factor BMAL1 is a principal driver of a molecular clock in mammals. Bmal1 deletion abolishes 24-hour activity patterning, one measure of clock output. We determined whether Bmal1 function is necessary for daily molecular oscillations in skin fibroblasts and liver slices. Unexpectedly, in Bmal1 knockout mice, both tissues exhibited 24-hour oscillations of the transcriptome, proteome, and phosphoproteome over 2 to 3 days in the absence of any exogenous drivers such as daily light or temperature cycles. This demonstrates a competent 24-hour molecular pacemaker in Bmal1 knockouts. We suggest that such oscillations might be underpinned by transcriptional regulation by the recruitment of ETS family transcription factors, and nontranscriptionally by co-opting redox oscillations. © 2020 American Association for the Advancement of Science. All rights reserved.
关键词	phosphoproteome proteome transcription factor ARNTL transcription factor Ets transcriptome unclassified drug cell component circadian rhythm gene gene expression genome molecular analysis animal experiment animal tissue Article Bmal1 gene circadian rhythm controlled study gene deletion gene expression regulation gene function gene knockout genotype knockout mouse light dark cycle liver mouse nonhuman oscillation oxidation reduction potential priority journal RNA sequence skin fibroblast temperature transcription regulation Mammalia Mus
语种	英语
来源机构	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/133715
推荐引用方式 GB/T 7714	Ray S.,Valekunja U.K.,Stangherlin A.,et al. Circadian rhythms in the absence of the clock gene Bmal1[J]. Science,2020,367(6479).
APA	Ray S..,Valekunja U.K..,Stangherlin A..,Howell S.A..,Snijders A.P..,...&Reddy A.B..(2020).Circadian rhythms in the absence of the clock gene Bmal1.,367(6479).
MLA	Ray S.,et al."Circadian rhythms in the absence of the clock gene Bmal1".367.6479(2020).