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Glucagon blockade restores functional β-cell mass in type 1 diabetic mice and enhances function of human islets 期刊论文
Proceedings of the National Academy of Sciences of the United States of America, 2021, 卷号: 118, 期号: 9
作者:  Wang M.-Y.;  Dean E.D.;  Quittner-Strom E.;  Zhu Y.;  Chowdhury K.H.;  Zhang Z.;  Zhao S.;  Li N.;  Ye R.;  Lee Y.;  Zhang Y.;  Chen S.;  Yu X.;  Leonard D.C.;  Poffenberger G.;  Deylen A.V.;  McCorkle S.K.;  Schlegel A.;  Sloop K.W.;  Efanov A.M.;  Gimeno R.E.;  Scherer P.E.;  Powers A.C.;  Unger R.H.;  Holland W.L.
收藏  |  浏览/下载：33/0  |  提交时间：2021/05/24
Structural basis of Gs and Gi recognition by the human glucagon receptor 期刊论文
, 2020, 卷号: 367, 期号: 6484
作者:  Qiao A.;  Han S.;  Li X.;  Li Z.;  Zhao P.;  Dai A.;  Chang R.;  Tai L.;  Tan Q.;  Chu X.;  Ma L.;  Thorsen T.S.;  Reedtz-Runge S.;  Yang D.;  Wang M.-W.;  Sexton P.M.;  Wootten D.;  Sun F.;  Zhao Q.;  Wu B.
收藏  |  浏览/下载：31/0  |  提交时间：2020/07/28
cyclic AMP  glucagon  glucagon receptor  inhibitory guanine nucleotide binding protein  stimulatory guanine nucleotide binding protein  glucagon receptor  inhibitory guanine nucleotide binding protein  protein binding  stimulatory guanine nucleotide binding protein  chemical binding  enzyme activity  gene expression  mutagenicity  protein  alpha helix  Article  binding affinity  carboxy terminal sequence  conformational transition  cryoelectron microscopy  human  molecular recognition  mutagenesis  priority journal  protein binding  protein function  protein protein interaction  protein structure  signal transduction  binding site  chemistry  metabolism  molecular model  protein conformation  ultrastructure  Binding Sites  Cryoelectron Microscopy  Glucagon  GTP-Binding Protein alpha Subunits, Gi-Go  GTP-Binding Protein alpha Subunits, Gs  Humans  Models, Molecular  Protein Binding  Protein Conformation  Protein Conformation, alpha-Helical  Receptors, Glucagon  Signal Transduction  
Maternal gut microbiota in pregnancy influences offspring metabolic phenotype in mice 期刊论文
, 2020, 卷号: 367, 期号: 6481
作者:  Kimura I.;  Miyamoto J.;  Ohue-Kitano R.;  Watanabe K.;  Yamada T.;  Onuki M.;  Aoki R.;  Isobe Y.;  Kashihara D.;  Inoue D.;  Inaba A.;  Takamura Y.;  Taira S.;  Kumaki S.;  Watanabe M.;  Ito M.;  Nakagawa F.;  Irie J.;  Kakuta H.;  Shinohara M.;  Iwatsuki K.;  Tsujimoto G.;  Ohno H.;  Arita M.;  Itoh H.;  Hase K.
收藏  |  浏览/下载：34/0  |  提交时间：2020/07/28
G protein coupled receptor  G protein coupled receptor 41  G protein coupled receptor 43  glucagon like peptide 1  short chain fatty acid  unclassified drug  disease incidence  experimental study  female  microbial community  phenotype  pregnancy  rodent  adult  animal cell  animal experiment  animal model  animal tissue  Article  C57BL 6 mouse  cell differentiation  controlled study  developmental stage  diet composition  diet supplementation  dietary exposure  disease exacerbation  disease predisposition  embryo  embryo development  energy metabolism  enteroendocrine cell  female  fiber intake  germfree animal  glucose intolerance  high risk pregnancy  hyperglycemia  Institute for Cancer Research mouse  insulin metabolism  intestine flora  lipid diet  low fiber diet  male  maternal nutrition  metabolic syndrome X  mouse  newborn  nonhuman  obesity  pancreas islet beta cell  phenotype  pregnancy  prenatal development  priority journal  progeny  protein expression  risk reduction  Mus  
A combined activation mechanism for the glucagon receptor 期刊论文
Proceedings of the National Academy of Sciences of the United States of America, 2020, 卷号: 117, 期号: 27
作者:  Mattedi G.;  Acosta-Gutiérrez S.;  Clark T.;  Gervasio F.L.
收藏  |  浏览/下载：0/0  |  提交时间：2021/01/06