气候变化领域集成服务门户(CCPortal): The genetic architecture of the human cerebral cortex

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DOI	10.1126/science.aay6690
	The genetic architecture of the human cerebral cortex
	Grasby K.L.; Jahanshad N.; Painter J.N.; Colodro-Conde L.; Bralten J.; Hibar D.P.; Lind P.A.; Pizzagalli F.; Ching C.R.K.; McMahon M.A.B.; Shatokhina N.; Zsembik L.C.P.; Thomopoulos S.I.; Zhu A.H.; Strike L.T.; Agartz I.; Alhusaini S.; Almeida M.A.A.; Alnæs D.; Amlien I.K.; Andersson M.; Ard T.; Armstrong N.J.; Ashley-Koch A.; Atkins J.R.; Bernard M.; Brouwer R.M.; Buimer E.E.L.; Bülow R.; Bürger C.; Cannon D.M.; Chakravarty M.; Chen Q.; Cheung J.W.; Couvy-Duchesne B.; Dale A.M.; Dalvie S.; de Araujo T.K.; de Zubicaray G.I.; de Zwarte S.M.C.; den Braber A.; Doan N.T.; Dohm K.; Ehrlich S.; Engelbrecht H.-R.; Erk S.; Fan C.C.; Fedko I.O.; Foley S.F.; Ford J.M.; Fukunaga M.; Garrett M.E.; Ge T.; Giddaluru S.; Goldman A.L.; Green M.J.; Groenewold N.A.; Grotegerd D.; Gurholt T.P.; Gutman B.A.; Hansell N.K.; Harris M.A.; Harrison M.B.; Haswell C.C.; Hauser M.; Herms S.; Heslenfeld D.J.; Ho N.F.; Hoehn D.; Hoffmann P.; Holleran L.; Hoogman M.; Hottenga J.-J.; Ikeda M.; Janowitz D.; Jansen I.E.; Jia T.; Jockwitz C.; Kanai R.; Karama S.; Kasperaviciute D.; Kaufmann T.; Kelly S.; Kikuchi M.; Klein M.; Knapp M.; Knodt A.R.; Krämer B.; Lam M.; Lancaster T.M.; Lee P.H.; Lett T.A.; Lewis L.B.; Lopes-Cendes I.; Luciano M.; Macciardi F.; Marquand A.F.; Mathias S.R.; Melzer T.R.; Milaneschi Y.; Mirza-Schreiber N.; Moreira J.C.V.; Mühleisen T.W.; Müller-Myhsok B.; Najt P.; Nakahara S.; Nho K.; Olde Loohuis L.M.; Orfanos D.P.; Pearson J.F.; Pitcher T.L.; Pütz B.; Quidé Y.; Ragothaman A.; Rashid F.M.; Reay W.R.; Redlich R.; Reinbold C.S.; Repple J.; Richard G.; Riedel B.C.; Risacher S.L.; Rocha C.S.; Mota N.R.; Salminen L.; Saremi A.; Saykin A.J.; Schlag F.; Schmaal L.; Schofield P.R.; Secolin R.; Shapland C.Y.; Shen L.; Shin J.; Shumskaya E.; Sønderby I.E.; Sprooten E.; Tansey K.E.; Teumer A.; Thalamuthu A.; Tordesillas-Gutiérrez D.; Turner J.A.; Uhlmann A.; Vallerga C.L.; van der Meer D.; van Donkelaar M.M.J.; van Eijk L.; van Erp T.G.M.; van Haren N.E.M.; van Rooij D.; van Tol M.-J.; Veldink J.H.; Verhoef E.; Walton E.; Wang M.; Wang Y.; Wardlaw J.M.; Wen W.; Westlye L.T.; Whelan C.D.; Witt S.H.; Wittfeld K.; Wolf C.; Wolfers T.; Wu J.Q.; Yasuda C.L.; Zaremba D.; Zhang Z.; Zwiers M.P.; Artiges E.; Assareh A.A.; Ayesa-Arriola R.; Belger A.; Brandt C.L.; Brown G.G.; Cichon S.; Curran J.E.; Davies G.E.; Degenhardt F.; Dennis M.F.; Dietsche B.; Djurovic S.; Doherty C.P.; Espiritu R.; Garijo D.; Gil Y.; Gowland P.A.; Green R.C.; Häusler A.N.; Heindel W.; Ho B.-C.; Hoffmann W.U.; Holsboer F.; Homuth G.; Hosten N.; Jack C.R.; Jang M.; Jansen A.; Kimbrel N.A.; Kolskår K.; Koops S.; Krug A.; Lim K.O.; Luykx J.J.; Mathalon D.H.; Mather K.A.; Mattay V.S.; Matthews S.; van Son J.M.; McEwen S.C.; Melle I.; Morris D.W.; Mueller B.A.; Nauck M.; Nordvik J.E.; Nöthen M.M.; O'Leary D.S.; Opel N.; Martinot M.-L.P.; Bruce Pike G.; Preda A.; Quinlan E.B.; Rasser P.E.; Ratnakar V.; Reppermund S.; Steen V.M.; Tooney P.A.; Torres F.R.; Veltman D.J.; Voyvodic J.T.; Whelan R.; White T.; Yamamori H.; Adams H.H.H.; Bis J.C.; Debette S.; Decarli C.; Fornage M.; Gudnason V.; Hofer E.; Arfan Ikram M.; Launer L.; Longstreth W.T.; Lopez O.L.; Mazoyer B.; Mosley T.H.; Roshchupkin G.V.; Satizabal C.L.; Schmidt R.; Seshadri S.; Yang Q.; Alvim M.K.M.; Ames D.; Anderson T.J.; Andreassen O.A.; Arias-Vasquez A.; Bastin M.E.; Baune B.T.; Beckham J.C.; Blangero J.; Boomsma D.I.; Brodaty H.; Brunner H.G.; Buckner R.L.; Buitelaar J.K.; Bustillo J.R.; Cahn W.; Cairns M.J.; Calhoun V.; Carr V.J.; Caseras X.; Caspers S.; Cavalleri G.L.; Cendes F.; Corvin A.; Crespo-Facorro B.; Dalrymple-Alford J.C.; Dannlowski U.; de Geus E.J.C.; Deary I.J.; Delanty N.; Depondt C.; Desrivières S.; Donohoe G.; Espeseth T.; Fernández G.; Fisher S.E.; Flor H.; Forstner A.J.; Francks C.; Franke B.; Glahn D.C.; Gollub R.L.; Grabe H.J.; Gruber O.; Håberg A.K.; Hariri A.R.; Hartman C.A.; Hashimoto R.; Heinz A.; Henskens F.A.; Hillegers M.H.J.; Hoekstra P.J.; Holmes A.J.; Elliot Hong L.; Hopkins W.D.; Hulshoff Pol H.E.; Jernigan T.L.; Jönsson E.G.; Kahn R.S.; Kennedy M.A.; Kircher T.T.J.; Kochunov P.; Kwok J.B.J.; Le Hellard S.; Loughland C.M.; Martin N.G.; Martinot J.-L.; McDonald C.; McMahon K.L.; Meyer-Lindenberg A.; Michie P.T.; Morey R.A.; Mowry B.; Nyberg L.; Oosterlaan J.; Ophoff R.A.; Pantelis C.; Paus T.; Pausova Z.; Penninx B.W.J.H.; Polderman T.J.C.; Posthuma D.; Rietschel M.; Roffman J.L.; Rowland L.M.; Sachdev P.S.; Sämann P.G.; Schall U.; Schumann G.; Scott R.J.; Sim K.; Sisodiya S.M.; Smoller J.W.; Sommer I.E.; Pourcain B.S.; Stein D.J.; Toga A.W.; Trollor J.N.; van der Wee N.J.A.; van't Ent D.; Völzke H.; Walter H.; Weber B.; Weinberger D.R.; Wright M.J.; Zhou J.; Stein J.L.; Thompson P.M.; Medland S.E.; Enhancing NeuroImaging Genetics through Meta-Analysis Consortium (ENIGMA)-Genetics working group
发表日期	2020
ISSN	0036-8075
卷号	367 期号:6484
英文摘要	The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder. © 2020 American Association for the Advancement of Science. All rights reserved.
关键词	brain genetic analysis meta-analysis resonance signaling surface area Article bioinformatics brain cortex brain function brain region brain tissue cortical thickness (brain)educational status evidence based medicine gene control gene locus genetic association genetic correlation genetic variability genome-wide association study human human genetics priority journal surface area tissue structure Wnt signaling anatomy and histology attention deficit disorder brain cortex brain mapping cognition genetic variation genetics meta analysis nuclear magnetic resonance imaging organ size Parkinson disease Attention Deficit Disorder with Hyperactivity Brain Mapping Cerebral Cortex Cognition Genetic Loci Genetic Variation Genome-Wide Association Study Humans Magnetic Resonance Imaging Organ Size Parkinson Disease
语种	英语
来源机构	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/133611
推荐引用方式 GB/T 7714	Grasby K.L.,Jahanshad N.,Painter J.N.,et al. The genetic architecture of the human cerebral cortex[J]. Science,2020,367(6484).
APA	Grasby K.L..,Jahanshad N..,Painter J.N..,Colodro-Conde L..,Bralten J..,...&Enhancing NeuroImaging Genetics through Meta-Analysis Consortium .(2020).The genetic architecture of the human cerebral cortex.,367(6484).
MLA	Grasby K.L.,et al."The genetic architecture of the human cerebral cortex".367.6484(2020).