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| Temperature-dependent sex determination is mediated by pSTAT3 repression of Kdm6b 期刊论文
, 2020, 卷号: 368, 期号: 6488
作者: Weber C.; Zhou Y.; Lee J.G.; Looger L.L.; Qian G.; Ge C.; Capel B.
  收藏 | 浏览/下载：35/0 | 提交时间：2020/07/28
STAT3 protein calcium histone demethylase STAT3 protein embryonic development gene expression sex determination temperature effect turtle animal cell animal experiment Article binding site calcium transport cell activation chromatin immunoprecipitation controlled study dimerization Dmrt1 gene embryo embryo development environmental temperature epigenetic repression female gene gene activation gene interaction gene targeting genetic transcription gonad high temperature immunofluorescence test Kdm6b gene male nonhuman priority journal protein phosphorylation real time polymerase chain reaction sex determination signal transduction temperature dependence thermoregulation transcription regulation upregulation Western blotting animal embryology gene expression regulation genetics metabolism phosphorylation sex determination process temperature turtle Reptilia Trachemys scripta Trachemys scripta elegans Animals Calcium Female Gene Expression Regulation, Developmental Jumonji Domain-Containing Histone Demethylases Male Phosphorylation Sex Determination Processes STAT3 Transcription Factor Temperature Transcription, Genetic Turtles |
| Therapeutic targeting of preleukemia cells in a mouse model of NPM1 mutant acute myeloid leukemia 期刊论文
, 2020, 卷号: 367, 期号: 6477
作者: Uckelmann H.J.; Kim S.M.; Wong E.M.; Hatton C.; Giovinazzo H.; Gadrey J.Y.; Krivtsov A.V.; Rücker F.G.; Döhner K.; McGeehan G.M.; Levine R.L.; Bullinger L.; Vassiliou G.S.; Armstrong S.A.
收藏 | 浏览/下载：35/0 | 提交时间：2020/07/28
antileukemic agent methionine unclassified drug vtp 50469 biological development cancer cell disease treatment mutation numerical model oral health acute myeloid leukemia animal cell animal experiment animal model antineoplastic activity Article cell proliferation cell self-renewal chromatin controlled study drug targeting gene gene mutation leukemia cell molecularly targeted therapy mouse mouse model nonhuman NPM1 gene preleukemia priority journal Mus |
| N6-methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcription 期刊论文
, 2020, 卷号: 367, 期号: 6477
作者: Liu J.; Dou X.; Chen C.; Chen C.; Liu C.; Michelle Xu M.; Zhao S.; Shen B.; Gao Y.; Han D.; He C.
收藏 | 浏览/下载：14/0 | 提交时间：2020/07/28
6 n methyladenosine chromosome associated regulatory RNA enhancer RNA messenger RNA promoter associated RNA repeat RNA RNA unclassified drug cell component chemical compound chromosome methylation RNA animal cell Article biodegradation chemical modification chromatin controlled study demethylation embryo embryonic stem cell exosome methylation METTL3 gene mouse nonhuman nuclear degradation priority journal transcription regulation Ythdc1 gene |
| Correlative three-dimensional super-resolution and block-face electron microscopy of whole vitreously frozen cells 期刊论文
, 2020, 卷号: 367, 期号: 6475
作者: Hoffman D.P.; Shtengel G.; Xu C.S.; Campbell K.R.; Freeman M.; Wang L.; Milkie D.E.; Pasolli H.A.; Iyer N.; Bogovic J.A.; Stabley D.R.; Shirinifard A.; Pang S.; Peale D.; Schaefer K.; Pomp W.; Chang C.-L.; Lippincott-Schwartz J.; Kirchhausen T.; Solecki D.J.; Betzig E.; Hess H.F.
收藏 | 浏览/下载：50/0 | 提交时间：2020/07/28
cell compartmentalization cryopreservation electron microscopy image resolution protein three-dimensional modeling ultrastructure article chromatin electron microscopy endoplasmic reticulum genetic transcription human cell mammal cell nerve cell culture protein domain ultrastructure whole cell workflow animal cell adhesion cells Chlorocebus aethiops cryoelectron microscopy CV-1 cell line fluorescence microscopy freezing HeLa cell line human mouse procedures three-dimensional imaging tumor cell line ultrastructure Mammalia Animals Cell Adhesion Cell Line, Tumor Cells Chlorocebus aethiops COS Cells Cryoelectron Microscopy Freezing HeLa Cells Humans Imaging, Three-Dimensional Mice Microscopy, Fluorescence |
| A programmable fate decision landscape underlies single-cell aging in yeast 期刊论文
, 2020, 卷号: 369, 期号: 6501
作者: Li Y.; Jiang Y.; Paxman J.; O'Laughlin R.; Klepin S.; Zhu Y.; Pillus L.; Tsimring L.S.; Hasty J.; Hao N.
收藏 | 浏览/下载：43/0 | 提交时间：2020/07/28
apoptosis article cell aging cell differentiation chromatin epigenetics lifespan noise nonhuman yeast |
| Structure of nucleosome-bound human BAF complex 期刊论文
, 2020, 卷号: 367, 期号: 6480
作者: He S.; Wu Z.; Tian Y.; Yu Z.; Yu J.; Wang X.; Li J.; Liu B.; Xu Y.
收藏 | 浏览/下载：37/0 | 提交时间：2020/07/28
actin related protein adenosine triphosphatase BRG1 BRM associated factor DNA multiprotein complex protein SWI retinoblastoma binding protein 2 SMARCC protein SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily B member 1 transcription factor transcription factor SNF unclassified drug cancer enzyme activity gene expression hydrolysis mutation protein alpha helix Article carboxy terminal sequence cell interaction cryoelectron microscopy disease association human malignant neoplasm molecular recognition mutation nucleosome priority journal protein function protein hydrolysis protein structure structure analysis Mammalia |
| Massively multiplex chemical transcriptomics at single-cell resolution 期刊论文
, 2020, 卷号: 367, 期号: 6473
作者: Srivatsan S.R.; McFaline-Figueroa J.L.; Ramani V.; Saunders L.; Cao J.; Packer J.; Pliner H.A.; Jackson D.L.; Daza R.M.; Christiansen L.; Zhang F.; Steemers F.; Shendure J.; Trapnell C.
收藏 | 浏览/下载：19/0 | 提交时间：2020/07/28
4 (2 aminoethylamino) 1,8 dimethylimidazo[1,2 a]quinoxaline abexinostat acetic acid belinostat cudc 101 fimepinostat givinostat histone deacetylase inhibitor m 344 n [2 [3 (1 piperazinylmethyl)imidazo[2,1 b]thiazol 6 yl]phenyl] 2 quinoxalinecarboxamide panobinostat pracinostat rec 2282 trametinib transcriptome trichostatin A unclassified drug transcriptome cancer cell chemical analysis detection method experimental study genetic analysis resolution A-549 cell line animal cell animal experiment Article cell function cell heterogeneity cell labeling cell proliferation chromatin controlled study dose response drug activity experimentation gene control genetic transcription human human cell K-562 cell line MCF-7 cell line mouse nonhuman pilot study priority journal proof of concept RNA sequence screening single cell analysis transcriptomics cell nucleus drug effect genetics genomics high throughput screening metabolism neoplasm procedures single cell analysis A549 Cells Acetates Cell Nucleus Chromatin Genomics High-Throughput Screening Assays Histone Deacetylase Inhibitors Humans K562 Cells MCF-7 Cells Neoplasms RNA-Seq Single-Cell Analysis Transcriptome |
| Vertebrate diapause preserves organisms long term through Polycomb complex members 期刊论文
, 2020, 卷号: 367, 期号: 6480
作者: Hu C.-K.; Wang W.; Brind'Amour J.; Singh P.P.; Adam Reeves G.; Lorincz M.C.; Alvarado A.S.; Brunet A.
收藏 | 浏览/下载：43/0 | 提交时间：2020/07/28
polycomb group protein protein CBX7 transcriptome unclassified drug diapause gene expression metabolism muscle vertebrate Article chromatin complex formation developmental gene diapause down regulation embryo development fertility gene gene expression regulation gene repression genetic regulation growth rate lifespan lipid metabolism metabolism muscle atrophy muscle gene neuromuscular junction nonhuman priority journal protein function tissue preservation upregulation vertebrate Cyprinodontoidei Nothobranchius furzeri Vertebrata |
| Enhanced sustainable green revolution yield via nitrogen-responsive chromatin modulation in rice 期刊论文
, 2020, 卷号: 367, 期号: 6478
作者: Wu K.; Wang S.; Song W.; Zhang J.; Wang Y.; Liu Q.; Yu J.; Ye Y.; Li S.; Chen J.; Zhao Y.; Wang J.; Wu X.; Wang M.; Zhang Y.; Liu B.; Wu Y.; Harberd N.P.; Fu X.
收藏 | 浏览/下载：43/0 | 提交时间：2020/07/28
DELLA protein gibberellin gibberellin insensitive dwarf1 histone H3 polycomb repressive complex 2 receptor transcription factor unclassified drug alternative agriculture chromosome gene expression genetic engineering green revolution inhibition molecular analysis nitrogen nutrient use efficiency protein rice agriculture allele Article chromatin immunoprecipitation controlled study D14 gene gene mutation genetic screening genetic transcription grain yield green revolution histone modification modulation ngr5 gene nitrogen availability nitrogen responsive chromatin modulation nonhuman OsSPL14 gene plant gene polymerase chain reaction priority journal protein protein interaction rice RNA sequencing varietas |
| Chromatin accessibility dynamics in a model of human forebrain development 期刊论文
, 2020, 卷号: 367, 期号: 6476
作者: Trevino A.E.; Sinnott-Armstrong N.; Andersen J.; Yoon S.-J.; Huber N.; Pritchard J.K.; Chang H.Y.; Greenleaf W.J.; Pașca S.P.
收藏 | 浏览/下载：25/0 | 提交时间：2020/07/28
brain cell component developmental biology developmental stage disease genetic analysis nervous system disorder Article brain cortex brain development brain nerve cell brain tissue cell differentiation cell migration chromatin controlled study environmental factor fluorescence activated cell sorting forebrain GABAergic system glia cell heredity high throughput sequencing human human cell human tissue pluripotent stem cell priority journal RNA isolation RNA sequence RNA sequencing |
