气候变化领域集成服务门户(CCPortal): A programmable fate decision landscape underlies single-cell aging in yeast

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DOI	10.1126/science.aax9552
	A programmable fate decision landscape underlies single-cell aging in yeast
	Li Y.; Jiang Y.; Paxman J.; O'Laughlin R.; Klepin S.; Zhu Y.; Pillus L.; Tsimring L.S.; Hasty J.; Hao N.
发表日期	2020
ISSN	10959203
起始页码	325
结束页码	329
卷号	369 期号:6501
英文摘要	Chromatin instability and mitochondrial decline are conserved processes that contribute to cellular aging. Although both processes have been explored individually in the context of their distinct signaling pathways, the mechanism that determines which process dominates during aging of individual cells is unknown. We show that interactions between the chromatin silencing and mitochondrial pathways lead to an epigenetic landscape of yeast replicative aging with multiple equilibrium states that represent different types of terminal states of aging. The structure of the landscape drives single-cell differentiation toward one of these states during aging, whereby the fate is determined quite early and is insensitive to intracellular noise. Guided by a quantitative model of the aging landscape, we genetically engineered a long-lived equilibrium state characterized by an extended life span. Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
关键词	apoptosis article cell aging cell differentiation chromatin epigenetics lifespan noise nonhuman yeast
语种	英语
来源机构	Science (New York, N.Y.)
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/133327
推荐引用方式 GB/T 7714	Li Y.,Jiang Y.,Paxman J.,et al. A programmable fate decision landscape underlies single-cell aging in yeast[J]. Science (New York, N.Y.),2020,369(6501).
APA	Li Y..,Jiang Y..,Paxman J..,O'Laughlin R..,Klepin S..,...&Hao N..(2020).A programmable fate decision landscape underlies single-cell aging in yeast.,369(6501).
MLA	Li Y.,et al."A programmable fate decision landscape underlies single-cell aging in yeast".369.6501(2020).