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| Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease 期刊论文
, 2020, 卷号: 368, 期号: 6497
作者: Dai W.; Zhang B.; Jiang X.-M.; Su H.; Li J.; Zhao Y.; Xie X.; Jin Z.; Peng J.; Liu F.; Li C.; Li Y.; Bai F.; Wang H.; Cheng X.; Cen X.; Hu S.; Yang X.; Wang J.; Liu X.; Xiao G.; Jiang H.; Rao Z.; Zhang L.-K.; Xu Y.; Yang H.; Liu H.
  收藏 | 浏览/下载：36/0 | 提交时间：2020/07/28
aldehyde antimicrobial activity drug enzyme activity infectivity inhibitor reaction kinetics viral disease Coronavirus SARS coronavirus 3C-like proteinase, Coronavirus antivirus agent cysteine proteinase viral protein animal Betacoronavirus chemical structure chemistry Chlorocebus aethiops Coronavirus infection dog drug design drug effect enzyme active site enzymology female human male mouse pandemic preclinical study protein tertiary structure Sprague Dawley rat toxicity testing Vero cell line virus pneumonia Animals Antiviral Agents Betacoronavirus Catalytic Domain Chlorocebus aethiops Coronavirus Infections Cysteine Endopeptidases Dogs Drug Design Drug Evaluation, Preclinical Female Humans Male Mice Molecular Structure Pandemics Pneumonia, Viral Protein Structure, Tertiary Rats, Sprague-Dawley Toxicity Tests Vero Cells Viral Nonstructural Proteins |
| PE/PPE proteins mediate nutrient transport across the outer membrane of Mycobacterium tuberculosis 期刊论文
, 2020, 卷号: 367, 期号: 6482
作者: Wang Q.; Boshoff H.I.M.; Harrison J.R.; Ray P.C.; Green S.R.; Wyatt P.G.; Barry Iii C.E.
收藏 | 浏览/下载：21/0 | 提交时间：2020/07/28
3,3 bis di(methylsulfonyl)propionamide antiinfective agent bacterial protein glucose glycerol magnesium phosphate propionamide derivative protein proline proline glutamate protein proline proline glutamate 51 unclassified drug amide bacterial protein lipid phthiocerol dimycocerosate propionamide thiol derivative cell component chemical compound membrane mutation protein tuberculosis antibiotic resistance Article bacterial cell bacterial cell wall bacterial growth bacterial outer membrane cell division drug structure Mycobacterium tuberculosis nonhuman nutrient uptake priority journal protein depletion cell membrane cell membrane permeability chemistry drug effect gene deletion genetics metabolism transport at the cellular level Mycobacterium tuberculosis Amides Bacterial Proteins Biological Transport Cell Membrane Cell Membrane Permeability Drug Resistance, Bacterial Gene Deletion Glucose Glycerol Lipids Mycobacterium tuberculosis Sulfhydryl Compounds |
| Rings rule three-dimensional active matter 期刊论文
, 2020, 卷号: 367, 期号: 6482
作者: Bartolo D.
收藏 | 浏览/下载：10/0 | 提交时间：2020/07/28
adenosine triphosphate crystal chemistry electric field element mobility fluid three-dimensional modeling two-dimensional flow Article chemical structure electricity eukaryotic cell geometry hydrodynamics liquid crystal molecular dynamics priority journal room temperature synthesis three-dimensional imaging virus particle |
| The Ccr4-Not complex monitors the translating ribosome for codon optimality 期刊论文
, 2020, 卷号: 368, 期号: 6488
作者: Buschauer R.; Matsuo Y.; Sugiyama T.; Chen Y.-H.; Alhusaini N.; Sweet T.; Ikeuchi K.; Cheng J.; Matsuki Y.; Nobuta R.; Gilmozzi A.; Berninghausen O.; Tesina P.; Becker T.; Coller J.; Inada T.; Beckmann R.
收藏 | 浏览/下载：40/0 | 提交时间：2020/07/28
exonuclease initiation factor 5A messenger RNA ribosome RNA transfer RNA ubiquitin protein ligase E3 bioassay biomonitoring cell component plant and fungus structure and form 40S ribosomal subunit adenylation amino terminal sequence Article binding site biochemical analysis carbon catabolite repressor 4 negative on tata complex codon complex formation controlled study cryoelectron microscopy homeostasis molecular interaction nonhuman priority journal protein conformation ribosome Saccharomyces cerevisiae sequence analysis ubiquitination Saccharomyces cerevisiae |
| Unconstrained genome targeting with near-PAMless engineered CRISPR-Cas9 variants 期刊论文
, 2020, 卷号: 368, 期号: 6488
作者: Walton R.T.; Christie K.A.; Whittaker M.N.; Kleinstiver B.P.
收藏 | 浏览/下载：20/0 | 提交时间：2020/07/28
adenine adenosine CRISPR associated endonuclease Cas9 cytosine guanosine SpG protein SpRY nuclease thymine unclassified drug Cas9 endonuclease Streptococcus pyogenes bacterium enzyme activity genetic engineering genetic variation genome Article CRISPR-CAS9 system DNA sequence enzyme activity gene editing gene targeting genetic variability human mutagenesis nonhuman priority journal protein engineering protein motif protein structure protospacer adjacent motif Streptococcus pyogenes chemistry CRISPR Cas system enzyme specificity gene editing gene targeting genetic predisposition genetics HEK293 cell line procedures protein domain Streptococcus pyogenes CRISPR-Associated Protein 9 CRISPR-Cas Systems Gene Editing Gene Targeting Genetic Predisposition to Disease HEK293 Cells Humans Mutagenesis Protein Domains Substrate Specificity |
| Liquid-liquid phase separation drives skin barrier formation 期刊论文
, 2020, 卷号: 367, 期号: 6483
作者: Quiroz F.G.; Fiore V.F.; Levorse J.; Polak L.; Wong E.; Pasolli H.A.; Fuchs E.
收藏 | 浏览/下载：27/0 | 提交时间：2020/07/28
filaggrin keratohyalin coalescence differentiation separation skin skin disorder stratification amino acid composition Article bioengineering biophysics cell differentiation cell function cell structure epidermis cell genetic transfection human keratinocyte liquid live cell imaging molecular dynamics nonhuman pH phase separation phase transition priority journal proteomics sequence analysis signal transduction skin skin surface Mus |
| Endoplasmic reticulum contact sites regulate the dynamics of membraneless organelles 期刊论文
, 2020, 卷号: 367, 期号: 6477
作者: Lee J.E.; Cathey P.I.; Wu H.; Parker R.; Voeltz G.K.
收藏 | 浏览/下载：19/0 | 提交时间：2020/07/28
cell component cell organelle membrane protein Article biogenesis cell division cell organelle cell population cell proliferation cell structure controlled study cytoplasm dimerization endoplasmic reticulum endoplasmic reticulum stress endosome fluorescence microscopy human human cell membraneless organelle mitochondrion priority journal ribonucleoprotein granule RNA translation stress granule |
| Structure of nucleosome-bound human BAF complex 期刊论文
, 2020, 卷号: 367, 期号: 6480
作者: He S.; Wu Z.; Tian Y.; Yu Z.; Yu J.; Wang X.; Li J.; Liu B.; Xu Y.
收藏 | 浏览/下载：32/0 | 提交时间：2020/07/28
actin related protein adenosine triphosphatase BRG1 BRM associated factor DNA multiprotein complex protein SWI retinoblastoma binding protein 2 SMARCC protein SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily B member 1 transcription factor transcription factor SNF unclassified drug cancer enzyme activity gene expression hydrolysis mutation protein alpha helix Article carboxy terminal sequence cell interaction cryoelectron microscopy disease association human malignant neoplasm molecular recognition mutation nucleosome priority journal protein function protein hydrolysis protein structure structure analysis Mammalia |
| TTC5 mediates autoregulation of tubulin via mRNA degradation 期刊论文
, 2020, 卷号: 367, 期号: 6473
作者: Lin Z.; Gasic I.; Chandrasekaran V.; Peters N.; Shao S.; Mitchison T.J.; Hegde R.S.
收藏 | 浏览/下载：22/0 | 提交时间：2020/07/28
messenger RNA mutant protein polypeptide recombinant protein regulator protein tetratricopeptide protein 5 tubulin unclassified drug biodegradation chromosome peptide protein RNA amino terminal sequence animal cell Article autoregulation binding site chromosome segregation controlled study cryoelectron microscopy genetic code human human cell Leporidae mitosis molecular model nonhuman priority journal protein analysis protein binding protein interaction protein structure reticulocyte ribosome RNA degradation RNA translation tubulin gene |
| De novo design of protein logic gates 期刊论文
, 2020, 卷号: 368, 期号: 6486
作者: Chen Z.; Kibler R.D.; Hunt A.; Busch F.; Pearl J.; Jia M.; VanAernum Z.L.; Wicky B.I.M.; Dods G.; Liao H.; Wilken M.S.; Ciarlo C.; Green S.; El-Samad H.; Stamatoyannopoulos J.; Wysocki V.H.; Jewett M.C.; Boyken S.E.; Baker D.
收藏 | 浏览/下载：26/0 | 提交时间：2020/07/28
cell design method gene expression genetic analysis protein activation domain Article binding affinity circular dichroism controlled study de novo design design DNA binding motif enzyme activity genetic transcription human human cell hydrogen bond hydrophobicity mass spectrometry native mass spectrometry nonhuman priority journal protein protein interaction protein structure RNA translation stoichiometry thermodynamics two hybrid system X ray crystallography chemistry genetics logic metabolism protein analysis protein engineering protein processing synthetic biology T lymphocyte yeast HAVCR2 protein, human hepatitis A virus cellular receptor 2 Hepatitis A Virus Cellular Receptor 2 Humans Logic Mass Spectrometry Protein Engineering Protein Interaction Maps Protein Processing, Post-Translational Synthetic Biology T-Lymphocytes Transcription, Genetic Yeasts |
