气候变化领域集成服务门户(CCPortal): Endoplasmic reticulum contact sites regulate the dynamics of membraneless organelles

CCPortal

DOI	10.1126/science.aay7108
	Endoplasmic reticulum contact sites regulate the dynamics of membraneless organelles
	Lee J.E.; Cathey P.I.; Wu H.; Parker R.; Voeltz G.K.
发表日期	2020
ISSN	0036-8075
卷号	367 期号:6477
英文摘要	Tethered interactions between the endoplasmic reticulum (ER) and other membrane-bound organelles allow for efficient transfer of ions and/or macromolecules and provide a platform for organelle fission. Here, we describe an unconventional interface between membraneless ribonucleoprotein granules, such as processing bodies (P-bodies, or PBs) and stress granules, and the ER membrane. We found that PBs are tethered at molecular distances to the ER in human cells in a tunable fashion. ER-PB contact and PB biogenesis were modulated by altering PB composition, ER shape, or ER translational capacity. Furthermore, ER contact sites defined the position where PB and stress granule fission occurs. We thus suggest that the ER plays a fundamental role in regulating the assembly and disassembly of membraneless organelles. © 2020 American Association for the Advancement of Science. All rights reserved.
关键词	cell component cell organelle membrane protein Article biogenesis cell division cell organelle cell population cell proliferation cell structure controlled study cytoplasm dimerization endoplasmic reticulum endoplasmic reticulum stress endosome fluorescence microscopy human human cell membraneless organelle mitochondrion priority journal ribonucleoprotein granule RNA translation stress granule
语种	英语
来源机构	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/133751
推荐引用方式 GB/T 7714	Lee J.E.,Cathey P.I.,Wu H.,et al. Endoplasmic reticulum contact sites regulate the dynamics of membraneless organelles[J]. Science,2020,367(6477).
APA	Lee J.E.,Cathey P.I.,Wu H.,Parker R.,&Voeltz G.K..(2020).Endoplasmic reticulum contact sites regulate the dynamics of membraneless organelles.,367(6477).
MLA	Lee J.E.,et al."Endoplasmic reticulum contact sites regulate the dynamics of membraneless organelles".367.6477(2020).