气候变化领域集成服务门户(CCPortal): TTC5 mediates autoregulation of tubulin via mRNA degradation

CCPortal

DOI	10.1126/science.aaz4352
	TTC5 mediates autoregulation of tubulin via mRNA degradation
	Lin Z.; Gasic I.; Chandrasekaran V.; Peters N.; Shao S.; Mitchison T.J.; Hegde R.S.
发表日期	2020
ISSN	0036-8075
起始页码	100
结束页码	104
卷号	367 期号:6473
英文摘要	Tubulins play crucial roles in cell division, intracellular traffic, and cell shape. Tubulin concentration is autoregulated by feedback control of messenger RNA (mRNA) degradation via an unknown mechanism. We identified tetratricopeptide protein 5 (TTC5) as a tubulin-specific ribosome-associating factor that triggers cotranslational degradation of tubulin mRNAs in response to excess soluble tubulin. Structural analysis revealed that TTC5 binds near the ribosome exit tunnel and engages the amino terminus of nascent tubulins. TTC5 mutants incapable of ribosome or nascent tubulin interaction abolished tubulin autoregulation and showed chromosome segregation defects during mitosis. Our findings show how a subset of mRNAs can be targeted for coordinated degradation by a specificity factor that recognizes the nascent polypeptides they encode. © 2020 American Association for the Advancement of Science. All rights reserved.
关键词	messenger RNA mutant protein polypeptide recombinant protein regulator protein tetratricopeptide protein 5 tubulin unclassified drug biodegradation chromosome peptide protein RNA amino terminal sequence animal cell Article autoregulation binding site chromosome segregation controlled study cryoelectron microscopy genetic code human human cell Leporidae mitosis molecular model nonhuman priority journal protein analysis protein binding protein interaction protein structure reticulocyte ribosome RNA degradation RNA translation tubulin gene
语种	英语
来源机构	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/133806
推荐引用方式 GB/T 7714	Lin Z.,Gasic I.,Chandrasekaran V.,et al. TTC5 mediates autoregulation of tubulin via mRNA degradation[J]. Science,2020,367(6473).
APA	Lin Z..,Gasic I..,Chandrasekaran V..,Peters N..,Shao S..,...&Hegde R.S..(2020).TTC5 mediates autoregulation of tubulin via mRNA degradation.,367(6473).
MLA	Lin Z.,et al."TTC5 mediates autoregulation of tubulin via mRNA degradation".367.6473(2020).