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| CFLIPL protects macrophages from LPS-induced pyroptosis via inhibition of complex II formation 期刊论文
, 2020, 卷号: 367, 期号: 6484
作者: Muendlein H.I.; Jetton D.; Connolly W.M.; Eidell K.P.; Magri Z.; Smirnova I.; Poltorak A.
  收藏 | 浏览/下载：49/0 | 提交时间：2020/07/28
FLICE inhibitory protein interleukin 1beta lipopolysaccharide messenger RNA succinate dehydrogenase (ubiquinone) Casp1 protein, mouse caspase 8 Cflar protein, mouse cryopyrin FLICE inhibitory protein IL1B protein, mouse inflammasome interleukin 1beta interleukin 1beta converting enzyme lipopolysaccharide succinate dehydrogenase (ubiquinone) cell enzyme activity inhibition maturation protein animal cell animal experiment Article bone marrow derived macrophage cell death cell protection complex formation controlled study cytokine release in vitro study inflammation mouse nonhuman priority journal protein analysis protein degradation protein function protein interaction pyroptosis animal gene knockdown genetics immunology macrophage macrophage activation metabolism physiology Murinae Animals CASP8 and FADD-Like Apoptosis Regulating Protein Caspase 1 Caspase 8 Electron Transport Complex II Gene Knockdown Techniques Inflammasomes Interleukin-1beta Lipopolysaccharides Macrophage Activation Macrophages Mice NLR Family, Pyrin Domain-Containing 3 Protein Pyroptosis |
| Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations 期刊论文
, 2020, 卷号: 367, 期号: 6478
作者: Wilmes S.; Hafer M.; Vuorio J.; Tucker J.A.; Winkelmann H.; Löchte S.; Stanly T.A.; Pulgar Prieto K.D.; Poojari C.; Sharma V.; Richter C.P.; Kurre R.; Hubbard S.R.; Christopher Garcia K.; Moraga I.; Vattulainen I.; Hitchcock I.S.; Piehler J.
收藏 | 浏览/下载：47/0 | 提交时间：2020/07/28
cytokine receptor homodimer Janus kinase 2 ligand oncoprotein cancer enzyme enzyme activity membrane molecular analysis mutation protein activation analysis Article cell membrane computer model controlled study dimerization fluorescence microscopy gene mutation HeLa cell line molecular dynamics mutant oncogene priority journal protein domain protein interaction quantitative analysis signal transduction |
| Computing cancer's weak spots 期刊论文
, 2020, 卷号: 368, 期号: 6496
作者: Khamsi R.
收藏 | 浏览/下载：46/0 | 提交时间：2020/07/28
ruxolitinib STAT3 protein antineoplastic agent transcription factor algorithm cancer computer simulation disease treatment drug development medicine Article cancer cell cancer radiotherapy enzyme inhibition gene activity gene expression regulation gene interaction gene mutation gene repression gene targeting human laboratory test malignant neoplasm molecular dynamics nonhuman oncologist priority journal RNA sequencing algorithm genetics mutation neoplasm personalized medicine procedures systems biology Algorithms Antineoplastic Agents Humans Mutation Neoplasms Precision Medicine Systems Biology Transcription Factors |
| An intrinsic oscillator drives the blood stage cycle of the malaria parasite Plasmodium falciparum 期刊论文
, 2020, 卷号: 368, 期号: 6492
作者: Smith L.M.; Motta F.C.; Chopra G.; Moch J.K.; Nerem R.R.; Cummins B.; Roche K.E.; Kelliher C.M.; Leman A.R.; Harer J.; Gedeon T.; Waters N.C.; Haase S.B.
收藏 | 浏览/下载：36/0 | 提交时间：2020/07/28
blood cell malaria parasite Plasmodium falciparum transcriptome animal blood circadian rhythm erythrocyte gene gene expression genetics growth, development and aging host parasite interaction life cycle stage malaria falciparum mouse parasitology physiology Plasmodium falciparum Animals Circadian Clocks Erythrocytes Gene Expression Genes, Protozoan Host-Parasite Interactions Life Cycle Stages Malaria, Falciparum Mice Plasmodium falciparum Transcriptome |
| Microenvironment mapping via Dexter energy transfer on immune cells 期刊论文
, 2020, 卷号: 367, 期号: 6482
作者: Geri J.B.; Oakley J.V.; Reyes-Robles T.; Wang T.; McCarver S.J.; White C.H.; Rodriguez-Rivera F.P.; Parker D.L.; Hett E.C.; Fadeyi O.O.; Oslund R.C.; MacMillan D.W.C.
收藏 | 浏览/下载：39/0 | 提交时间：2020/07/28
antibody conjugate carbene programmed death 1 ligand 1 methane programmed death 1 ligand 1 antibody catalysis catalyst cell component detection method enzyme enzyme activity protein antigen binding Article cell membrane energy transfer human immunocompetent cell immunological synapse lymphocyte photocatalysis priority journal protein analysis protein protein interaction tumor microenvironment catalysis chemistry energy transfer Jurkat cell line metabolism photochemistry procedures radiation response ultraviolet radiation B7-H1 Antigen Catalysis Cell Membrane Cellular Microenvironment Energy Transfer Humans Jurkat Cells Lymphocytes Methane Photochemical Processes Protein Interaction Mapping Protein Interaction Maps Ultraviolet Rays |
| The Ccr4-Not complex monitors the translating ribosome for codon optimality 期刊论文
, 2020, 卷号: 368, 期号: 6488
作者: Buschauer R.; Matsuo Y.; Sugiyama T.; Chen Y.-H.; Alhusaini N.; Sweet T.; Ikeuchi K.; Cheng J.; Matsuki Y.; Nobuta R.; Gilmozzi A.; Berninghausen O.; Tesina P.; Becker T.; Coller J.; Inada T.; Beckmann R.
收藏 | 浏览/下载：45/0 | 提交时间：2020/07/28
exonuclease initiation factor 5A messenger RNA ribosome RNA transfer RNA ubiquitin protein ligase E3 bioassay biomonitoring cell component plant and fungus structure and form 40S ribosomal subunit adenylation amino terminal sequence Article binding site biochemical analysis carbon catabolite repressor 4 negative on tata complex codon complex formation controlled study cryoelectron microscopy homeostasis molecular interaction nonhuman priority journal protein conformation ribosome Saccharomyces cerevisiae sequence analysis ubiquitination Saccharomyces cerevisiae |
| Temperature-dependent sex determination is mediated by pSTAT3 repression of Kdm6b 期刊论文
, 2020, 卷号: 368, 期号: 6488
作者: Weber C.; Zhou Y.; Lee J.G.; Looger L.L.; Qian G.; Ge C.; Capel B.
收藏 | 浏览/下载：35/0 | 提交时间：2020/07/28
STAT3 protein calcium histone demethylase STAT3 protein embryonic development gene expression sex determination temperature effect turtle animal cell animal experiment Article binding site calcium transport cell activation chromatin immunoprecipitation controlled study dimerization Dmrt1 gene embryo embryo development environmental temperature epigenetic repression female gene gene activation gene interaction gene targeting genetic transcription gonad high temperature immunofluorescence test Kdm6b gene male nonhuman priority journal protein phosphorylation real time polymerase chain reaction sex determination signal transduction temperature dependence thermoregulation transcription regulation upregulation Western blotting animal embryology gene expression regulation genetics metabolism phosphorylation sex determination process temperature turtle Reptilia Trachemys scripta Trachemys scripta elegans Animals Calcium Female Gene Expression Regulation, Developmental Jumonji Domain-Containing Histone Demethylases Male Phosphorylation Sex Determination Processes STAT3 Transcription Factor Temperature Transcription, Genetic Turtles |
| Structure of nucleosome-bound human BAF complex 期刊论文
, 2020, 卷号: 367, 期号: 6480
作者: He S.; Wu Z.; Tian Y.; Yu Z.; Yu J.; Wang X.; Li J.; Liu B.; Xu Y.
收藏 | 浏览/下载：37/0 | 提交时间：2020/07/28
actin related protein adenosine triphosphatase BRG1 BRM associated factor DNA multiprotein complex protein SWI retinoblastoma binding protein 2 SMARCC protein SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily B member 1 transcription factor transcription factor SNF unclassified drug cancer enzyme activity gene expression hydrolysis mutation protein alpha helix Article carboxy terminal sequence cell interaction cryoelectron microscopy disease association human malignant neoplasm molecular recognition mutation nucleosome priority journal protein function protein hydrolysis protein structure structure analysis Mammalia |
| Ancient origins of allosteric activation in a Ser-Thr kinase 期刊论文
, 2020, 卷号: 367, 期号: 6480
作者: Hadzipasic A.; Wilson C.; Nguyen V.; Kern N.; Kim C.; Pitsawong W.; Villali J.; Zheng Y.; Kern D.
收藏 | 浏览/下载：48/0 | 提交时间：2020/07/28
aurora A kinase microtubule associated protein TPX2 protein unclassified drug activation energy ancestry cell chemical binding experimental study fitness protein allosterism amino acid sequence Article binding affinity binding site enzyme activation enzyme activity enzyme binding enzyme localization enzyme phosphorylation gene duplication horizontal gene transfer human hydrophobicity intracellular signaling phylogenetic tree phylogeny priority journal protein binding protein localization protein protein interaction |
| TTC5 mediates autoregulation of tubulin via mRNA degradation 期刊论文
, 2020, 卷号: 367, 期号: 6473
作者: Lin Z.; Gasic I.; Chandrasekaran V.; Peters N.; Shao S.; Mitchison T.J.; Hegde R.S.
收藏 | 浏览/下载：26/0 | 提交时间：2020/07/28
messenger RNA mutant protein polypeptide recombinant protein regulator protein tetratricopeptide protein 5 tubulin unclassified drug biodegradation chromosome peptide protein RNA amino terminal sequence animal cell Article autoregulation binding site chromosome segregation controlled study cryoelectron microscopy genetic code human human cell Leporidae mitosis molecular model nonhuman priority journal protein analysis protein binding protein interaction protein structure reticulocyte ribosome RNA degradation RNA translation tubulin gene |
