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| DOI | 10.1126/science.aba4357 |
| An intrinsic oscillator drives the blood stage cycle of the malaria parasite Plasmodium falciparum | |
| Smith L.M.; Motta F.C.; Chopra G.; Moch J.K.; Nerem R.R.; Cummins B.; Roche K.E.; Kelliher C.M.; Leman A.R.; Harer J.; Gedeon T.; Waters N.C.; Haase S.B. | |
| 发表日期 | 2020 |
| ISSN | 0036-8075 |
| 起始页码 | 754 |
| 结束页码 | 759 |
| 卷号 | 368期号:6492 |
| 英文摘要 | The blood stage of the infection of the malaria parasite Plasmodium falciparum exhibits a 48-hour developmental cycle that culminates in the synchronous release of parasites from red blood cells, which triggers 48-hour fever cycles in the host. This cycle could be driven extrinsically by host circadian processes or by a parasite-intrinsic oscillator. To distinguish between these hypotheses, we examine the P. falciparum cycle in an in vitro culture system and show that the parasite has molecular signatures associated with circadian and cell cycle oscillators. Each of the four strains examined has a different period, which indicates strain-intrinsic period control. Finally, we demonstrate that parasites have low cell-to-cell variance in cycle period, on par with a circadian oscillator. We conclude that an intrinsic oscillator maintains Plasmodium’s rhythmic life cycle. © 2020 American Association for the Advancement of Science. All rights reserved. |
| 关键词 | bloodcellmalariaparasitePlasmodium falciparumtranscriptomeanimalbloodcircadian rhythmerythrocytegenegene expressiongeneticsgrowth, development and aginghost parasite interactionlife cycle stagemalaria falciparummouseparasitologyphysiologyPlasmodium falciparumAnimalsCircadian ClocksErythrocytesGene ExpressionGenes, ProtozoanHost-Parasite InteractionsLife Cycle StagesMalaria, FalciparumMicePlasmodium falciparumTranscriptome |
| 语种 | 英语 |
| 来源机构 | Science |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/133503 |
| 推荐引用方式 GB/T 7714 | Smith L.M.,Motta F.C.,Chopra G.,et al. An intrinsic oscillator drives the blood stage cycle of the malaria parasite Plasmodium falciparum[J]. Science,2020,368(6492). |
| APA | Smith L.M..,Motta F.C..,Chopra G..,Moch J.K..,Nerem R.R..,...&Haase S.B..(2020).An intrinsic oscillator drives the blood stage cycle of the malaria parasite Plasmodium falciparum.,368(6492). |
| MLA | Smith L.M.,et al."An intrinsic oscillator drives the blood stage cycle of the malaria parasite Plasmodium falciparum".368.6492(2020). |
| 条目包含的文件 | 条目无相关文件。 | |||||
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