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The Ccr4-Not complex monitors the translating ribosome for codon optimality 期刊论文
, 2020, 卷号: 368, 期号: 6488
作者:  Buschauer R.;  Matsuo Y.;  Sugiyama T.;  Chen Y.-H.;  Alhusaini N.;  Sweet T.;  Ikeuchi K.;  Cheng J.;  Matsuki Y.;  Nobuta R.;  Gilmozzi A.;  Berninghausen O.;  Tesina P.;  Becker T.;  Coller J.;  Inada T.;  Beckmann R.
收藏  |  浏览/下载：45/0  |  提交时间：2020/07/28
exonuclease  initiation factor 5A  messenger RNA  ribosome RNA  transfer RNA  ubiquitin protein ligase E3  bioassay  biomonitoring  cell component  plant and fungus structure and form  40S ribosomal subunit  adenylation  amino terminal sequence  Article  binding site  biochemical analysis  carbon catabolite repressor 4 negative on tata complex  codon  complex formation  controlled study  cryoelectron microscopy  homeostasis  molecular interaction  nonhuman  priority journal  protein conformation  ribosome  Saccharomyces cerevisiae  sequence analysis  ubiquitination  Saccharomyces cerevisiae  
Temperature-dependent sex determination is mediated by pSTAT3 repression of Kdm6b 期刊论文
, 2020, 卷号: 368, 期号: 6488
作者:  Weber C.;  Zhou Y.;  Lee J.G.;  Looger L.L.;  Qian G.;  Ge C.;  Capel B.
收藏  |  浏览/下载：35/0  |  提交时间：2020/07/28
STAT3 protein  calcium  histone demethylase  STAT3 protein  embryonic development  gene expression  sex determination  temperature effect  turtle  animal cell  animal experiment  Article  binding site  calcium transport  cell activation  chromatin immunoprecipitation  controlled study  dimerization  Dmrt1 gene  embryo  embryo development  environmental temperature  epigenetic repression  female  gene  gene activation  gene interaction  gene targeting  genetic transcription  gonad  high temperature  immunofluorescence test  Kdm6b gene  male  nonhuman  priority journal  protein phosphorylation  real time polymerase chain reaction  sex determination  signal transduction  temperature dependence  thermoregulation  transcription regulation  upregulation  Western blotting  animal  embryology  gene expression regulation  genetics  metabolism  phosphorylation  sex determination process  temperature  turtle  Reptilia  Trachemys scripta  Trachemys scripta elegans  Animals  Calcium  Female  Gene Expression Regulation, Developmental  Jumonji Domain-Containing Histone Demethylases  Male  Phosphorylation  Sex Determination Processes  STAT3 Transcription Factor  Temperature  Transcription, Genetic  Turtles  
A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV 期刊论文
, 2020, 卷号: 368, 期号: 6491
作者:  Yuan M.;  Wu N.C.;  Zhu X.;  Lee C.-C.D.;  So R.T.Y.;  Lv H.;  Mok C.K.P.;  Wilson I.A.
收藏  |  浏览/下载：25/0  |  提交时间：2020/07/28
angiotensin converting enzyme 2  epitope  neutralizing antibody  virus hemagglutinin  virus spike protein  angiotensin converting enzyme 2  coronavirus receptors  coronavirus spike glycoprotein  dipeptidyl carboxypeptidase  epitope  neutralizing antibody  spike glycoprotein, SARS-CoV  spike protein, SARS-CoV-2  virus antibody  virus antigen  virus receptor  antibody  antigen  chemical binding  crystal structure  protein  respiratory disease  viral disease  virus  amino terminal sequence  antibody isolation  antigen binding  antigenicity  Article  binding affinity  binding site  conservation biology  controlled study  coronavirus disease 2019  cross reaction  cryoelectron microscopy  crystal structure  enzyme linked immunosorbent assay  epidemic  glycosylation  human  hydrophobicity  immune response  in vitro study  in vivo study  light chain  nonhuman  priority journal  protein conformation  protein domain  protein interaction  protein localization  protein structure  protein targeting  receptor binding  SARS coronavirus  Severe acute respiratory syndrome coronavirus 2  amino acid sequence  antibody affinity  Betacoronavirus  binding site  chemistry  immunology  metabolism  molecular model  SARS coronavirus  X ray crystallography  Coronavirus  SARS coronavirus  Amino Acid Sequence  Antibodies, Neutralizing  Antibodies, Viral  Antibody Affinity  Antigens, Viral  Betacoronavirus  Binding Sites  Cross Reactions  Crystallography, X-Ray  Epitopes  Models, Molecular  Peptidyl-Dipeptidase A  Protein Conformation  Protein Domains  Protein Interaction Domains and Motifs  Receptors, Virus  SARS Virus  Spike Glycoprotein, Coronavirus  
Structural basis of Gs and Gi recognition by the human glucagon receptor 期刊论文
, 2020, 卷号: 367, 期号: 6484
作者:  Qiao A.;  Han S.;  Li X.;  Li Z.;  Zhao P.;  Dai A.;  Chang R.;  Tai L.;  Tan Q.;  Chu X.;  Ma L.;  Thorsen T.S.;  Reedtz-Runge S.;  Yang D.;  Wang M.-W.;  Sexton P.M.;  Wootten D.;  Sun F.;  Zhao Q.;  Wu B.
收藏  |  浏览/下载：43/0  |  提交时间：2020/07/28
cyclic AMP  glucagon  glucagon receptor  inhibitory guanine nucleotide binding protein  stimulatory guanine nucleotide binding protein  glucagon receptor  inhibitory guanine nucleotide binding protein  protein binding  stimulatory guanine nucleotide binding protein  chemical binding  enzyme activity  gene expression  mutagenicity  protein  alpha helix  Article  binding affinity  carboxy terminal sequence  conformational transition  cryoelectron microscopy  human  molecular recognition  mutagenesis  priority journal  protein binding  protein function  protein protein interaction  protein structure  signal transduction  binding site  chemistry  metabolism  molecular model  protein conformation  ultrastructure  Binding Sites  Cryoelectron Microscopy  Glucagon  GTP-Binding Protein alpha Subunits, Gi-Go  GTP-Binding Protein alpha Subunits, Gs  Humans  Models, Molecular  Protein Binding  Protein Conformation  Protein Conformation, alpha-Helical  Receptors, Glucagon  Signal Transduction  
Marching to another clock 期刊论文
, 2020, 卷号: 367, 期号: 6479
作者:  Brown S.A.;  Sato M.
收藏  |  浏览/下载：42/0  |  提交时间：2020/07/28
RNA  transcription factor ARNTL  transcription factor CLOCK  transcription factor Ets  brain  circadian rhythm  molecular analysis  physiological response  protein  animal cell  animal tissue  Article  binding site  cell metabolism  circadian rhythm  controlled study  feedback system  genetic transcription  molecular dynamics  mouse  nonhuman  oxidation reduction reaction  priority journal  protein analysis  protein binding  protein expression  protein function  RNA analysis  RNA transcription  RNA translation  suprachiasmatic nucleus  music  walking  Circadian Rhythm  Music  Walking  
Angiotensin and biased analogs induce structurally distinct active conformations within a GPCR 期刊论文
, 2020, 卷号: 367, 期号: 6480
作者:  Wingler L.M.;  Skiba M.A.;  McMahon C.;  Staus D.P.;  Kleinhenz A.L.W.;  Suomivuori C.-M.;  Latorraca N.R.;  Dror R.O.;  Lefkowitz R.J.;  Kruse A.C.
收藏  |  浏览/下载：36/0  |  提交时间：2020/07/28
angiotensin 1 receptor  beta arrestin  G protein coupled receptor  biochemistry  crystal chemistry  crystal structure  physiological response  protein  signaling  allosterism  alpha helix  amino terminal sequence  Article  binding affinity  binding site  carboxy terminal sequence  conformational transition  crystallization  hydrogen bond  molecular dynamics  priority journal  protein binding  protein conformation  protein protein interaction  protein stability  signal transduction  thermostability  
Structural insights into immunoglobulin M 期刊论文
, 2020, 卷号: 367, 期号: 6481
作者:  Li Y.;  Wang G.;  Li N.;  Wang Y.;  Zhu Q.;  Chu H.;  Wu W.;  Tan Y.;  Yu F.;  Su X.-D.;  Gao N.;  Xiao J.
收藏  |  浏览/下载：43/0  |  提交时间：2020/07/28
immunoglobulin M  secretory component  antibody  immunity  molecular analysis  polymer  protein  Article  binding site  conformational transition  cryoelectron microscopy  crystal structure  human  hydrophobicity  nonhuman  oligomerization  priority journal  protein assembly  protein domain  protein function  protein interaction  protein stability  protein structure  protein transport  surface area  
Ancient origins of allosteric activation in a Ser-Thr kinase 期刊论文
, 2020, 卷号: 367, 期号: 6480
作者:  Hadzipasic A.;  Wilson C.;  Nguyen V.;  Kern N.;  Kim C.;  Pitsawong W.;  Villali J.;  Zheng Y.;  Kern D.
收藏  |  浏览/下载：48/0  |  提交时间：2020/07/28
aurora A kinase  microtubule associated protein  TPX2 protein  unclassified drug  activation energy  ancestry  cell  chemical binding  experimental study  fitness  protein  allosterism  amino acid sequence  Article  binding affinity  binding site  enzyme activation  enzyme activity  enzyme binding  enzyme localization  enzyme phosphorylation  gene duplication  horizontal gene transfer  human  hydrophobicity  intracellular signaling  phylogenetic tree  phylogeny  priority journal  protein binding  protein localization  protein protein interaction  
TTC5 mediates autoregulation of tubulin via mRNA degradation 期刊论文
, 2020, 卷号: 367, 期号: 6473
作者:  Lin Z.;  Gasic I.;  Chandrasekaran V.;  Peters N.;  Shao S.;  Mitchison T.J.;  Hegde R.S.
收藏  |  浏览/下载：26/0  |  提交时间：2020/07/28
messenger RNA  mutant protein  polypeptide  recombinant protein  regulator protein  tetratricopeptide protein 5  tubulin  unclassified drug  biodegradation  chromosome  peptide  protein  RNA  amino terminal sequence  animal cell  Article  autoregulation  binding site  chromosome segregation  controlled study  cryoelectron microscopy  genetic code  human  human cell  Leporidae  mitosis  molecular model  nonhuman  priority journal  protein analysis  protein binding  protein interaction  protein structure  reticulocyte  ribosome  RNA degradation  RNA translation  tubulin gene  
Structure of a trapped radical transfer pathway within a ribonucleotide reductase holocomplex 期刊论文
, 2020, 卷号: 368, 期号: 6489
作者:  Kang G.;  Taguchi A.T.;  Stubbe J.;  Drennan C.L.
收藏  |  浏览/下载：50/0  |  提交时间：2020/07/28
ribonucleotide reductase  DNA  enzyme  enzyme activity  radical  Article  beta sheet  binding site  catalysis  cryoelectron microscopy  enzyme active site  enzyme activity  enzyme binding  enzyme conformation  enzyme structure  enzyme subunit  nonhuman  priority journal  signal transduction