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Zhang Y. [4]
Zhao Y. [4]
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文献类型
期刊论文 [41]
发表日期
2020 [41]
语种
英语 [41]
来源机构
Science [41]
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Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease
期刊论文
, 2020, 卷号: 368, 期号: 6497
作者:
Dai W.
;
Zhang B.
;
Jiang X.-M.
;
Su H.
;
Li J.
;
Zhao Y.
;
Xie X.
;
Jin Z.
;
Peng J.
;
Liu F.
;
Li C.
;
Li Y.
;
Bai F.
;
Wang H.
;
Cheng X.
;
Cen X.
;
Hu S.
;
Yang X.
;
Wang J.
;
Liu X.
;
Xiao G.
;
Jiang H.
;
Rao Z.
;
Zhang L.-K.
;
Xu Y.
;
Yang H.
;
Liu H.
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2020/07/28
aldehyde
antimicrobial activity
drug
enzyme activity
infectivity
inhibitor
reaction kinetics
viral disease
Coronavirus
SARS coronavirus
3C-like proteinase, Coronavirus
antivirus agent
cysteine proteinase
viral protein
animal
Betacoronavirus
chemical structure
chemistry
Chlorocebus aethiops
Coronavirus infection
dog
drug design
drug effect
enzyme active site
enzymology
female
human
male
mouse
pandemic
preclinical study
protein tertiary structure
Sprague Dawley rat
toxicity testing
Vero cell line
virus pneumonia
Animals
Antiviral Agents
Betacoronavirus
Catalytic Domain
Chlorocebus aethiops
Coronavirus Infections
Cysteine Endopeptidases
Dogs
Drug Design
Drug Evaluation, Preclinical
Female
Humans
Male
Mice
Molecular Structure
Pandemics
Pneumonia, Viral
Protein Structure, Tertiary
Rats, Sprague-Dawley
Toxicity Tests
Vero Cells
Viral Nonstructural Proteins
T cells with dysfunctional mitochondria induce multimorbidity and premature senescence
期刊论文
, 2020, 卷号: 368, 期号: 6497
作者:
Desdín-Micó G.
;
Soto-Heredero G.
;
Aranda J.F.
;
Oller J.
;
Carrasco E.
;
Gabandé-Rodríguez E.
;
Blanco E.M.
;
Alfranca A.
;
Cussó L.
;
Desco M.
;
Ibañez B.
;
Gortazar A.R.
;
Fernández-Marcos P.
;
Navarro M.N.
;
Hernaez B.
;
Alcamí A.
;
Baixauli F.
;
Mittelbrunn M.
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2020/07/28
cardiovascular disease
enzyme activity
gene expression
metabolism
mitochondrial DNA
morbidity
senescence
tumor
Mus
DNA binding protein
mitochondrial protein
mitochondrial transcription factor A
nicotinamide adenine dinucleotide
transcription factor
tumor necrosis factor
animal
cytokine release syndrome
female
fitness
gene deletion
genetics
immunology
inflammation
longevity
male
metabolism
mitochondrion
mouse
multiple chronic conditions
mutant mouse strain
premature aging
T lymphocyte
ultrastructure
Aging, Premature
Animals
Cytokine Release Syndrome
DNA-Binding Proteins
Female
Gene Deletion
Inflammation
Longevity
Male
Mice
Mice, Mutant Strains
Mitochondria
Mitochondrial Proteins
Multimorbidity
NAD
Physical Fitness
T-Lymphocytes
Transcription Factors
Tumor Necrosis Factor-alpha
Membrane-proximal F-actin restricts local membrane protrusions and directs cell migration
期刊论文
, 2020, 卷号: 368, 期号: 6496
作者:
Bisaria A.
;
Hayer A.
;
Garbett D.
;
Cohen D.
;
Meyer T.
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2020/07/28
cell component
concentration (composition)
membrane
polymerization
protein
actin
green fluorescent protein
cell membrane
cell motion
cell polarity
cell surface
chemistry
genetics
human
metabolism
umbilical vein endothelial cell
Actins
Cell Membrane
Cell Movement
Cell Polarity
Cell Surface Extensions
Green Fluorescent Proteins
Human Umbilical Vein Endothelial Cells
Humans
Structure of the RNA-dependent RNA polymerase from COVID-19 virus
期刊论文
, 2020, 卷号: 368, 期号: 6492
作者:
Gao Y.
;
Yan L.
;
Huang Y.
;
Liu F.
;
Zhao Y.
;
Cao L.
;
Wang T.
;
Sun Q.
;
Ming Z.
;
Zhang L.
;
Ge J.
;
Zheng L.
;
Zhang Y.
;
Wang H.
;
Zhu Y.
;
Zhu C.
;
Hu T.
;
Hua T.
;
Zhang B.
;
Yang X.
;
Li J.
;
Yang H.
;
Liu Z.
;
Xu W.
;
Guddat L.W.
;
Wang Q.
;
Lou Z.
;
Rao Z.
收藏
  |  
浏览/下载:40/0
  |  
提交时间:2020/07/28
comparative study
drug
electron microscopy
enzyme
enzyme activity
RNA
virus
Coronavirus
SARS coronavirus
adenosine phosphate
alanine
antivirus agent
NSP7 protein, SARS-CoV-2
NSP8 protein, SARS-CoV-2
remdesivir
RNA directed RNA polymerase
RNA-dependent RNA polymerase, coronavirus
viral protein
beta sheet
Betacoronavirus
chemistry
cryoelectron microscopy
drug design
enzyme active site
enzymology
metabolism
molecular model
protein domain
ultrastructure
Adenosine Monophosphate
Alanine
Antiviral Agents
Betacoronavirus
Catalytic Domain
Cryoelectron Microscopy
Drug Design
Models, Molecular
Protein Conformation, beta-Strand
Protein Domains
RNA Replicase
Viral Nonstructural Proteins
Transcription polymerase-catalyzed emergence of novel RNA replicons
期刊论文
, 2020, 卷号: 368, 期号: 6487
作者:
Jain N.
;
Blauch L.R.
;
Szymanski M.R.
;
Das R.
;
Tang S.K.Y.
;
Yin Y.W.
;
Fire A.Z.
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2020/07/28
cell component
enzyme
enzyme activity
genetic analysis
RNA
article
bacteriophage
catalysis
DNA replication origin
heredity
in vitro study
nonhuman
plant seed
replicon
RNA replication
synthesis
transcription initiation
biocatalysis
biosynthesis
genetic transcription
metabolism
Animalia
Hepatitis delta virus
Viroids
bacteriophage T7 RNA polymerase
DNA directed RNA polymerase
RNA
viral protein
Biocatalysis
DNA-Directed RNA Polymerases
Replicon
RNA
Transcription, Genetic
Viral Proteins
Microenvironment mapping via Dexter energy transfer on immune cells
期刊论文
, 2020, 卷号: 367, 期号: 6482
作者:
Geri J.B.
;
Oakley J.V.
;
Reyes-Robles T.
;
Wang T.
;
McCarver S.J.
;
White C.H.
;
Rodriguez-Rivera F.P.
;
Parker D.L.
;
Hett E.C.
;
Fadeyi O.O.
;
Oslund R.C.
;
MacMillan D.W.C.
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2020/07/28
antibody conjugate
carbene
programmed death 1 ligand 1
methane
programmed death 1 ligand 1
antibody
catalysis
catalyst
cell component
detection method
enzyme
enzyme activity
protein
antigen binding
Article
cell membrane
energy transfer
human
immunocompetent cell
immunological synapse
lymphocyte
photocatalysis
priority journal
protein analysis
protein protein interaction
tumor microenvironment
catalysis
chemistry
energy transfer
Jurkat cell line
metabolism
photochemistry
procedures
radiation response
ultraviolet radiation
B7-H1 Antigen
Catalysis
Cell Membrane
Cellular Microenvironment
Energy Transfer
Humans
Jurkat Cells
Lymphocytes
Methane
Photochemical Processes
Protein Interaction Mapping
Protein Interaction Maps
Ultraviolet Rays
PE/PPE proteins mediate nutrient transport across the outer membrane of Mycobacterium tuberculosis
期刊论文
, 2020, 卷号: 367, 期号: 6482
作者:
Wang Q.
;
Boshoff H.I.M.
;
Harrison J.R.
;
Ray P.C.
;
Green S.R.
;
Wyatt P.G.
;
Barry Iii C.E.
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2020/07/28
3,3 bis di(methylsulfonyl)propionamide
antiinfective agent
bacterial protein
glucose
glycerol
magnesium
phosphate
propionamide derivative
protein proline proline glutamate
protein proline proline glutamate 51
unclassified drug
amide
bacterial protein
lipid
phthiocerol dimycocerosate
propionamide
thiol derivative
cell component
chemical compound
membrane
mutation
protein
tuberculosis
antibiotic resistance
Article
bacterial cell
bacterial cell wall
bacterial growth
bacterial outer membrane
cell division
drug structure
Mycobacterium tuberculosis
nonhuman
nutrient uptake
priority journal
protein depletion
cell membrane
cell membrane permeability
chemistry
drug effect
gene deletion
genetics
metabolism
transport at the cellular level
Mycobacterium tuberculosis
Amides
Bacterial Proteins
Biological Transport
Cell Membrane
Cell Membrane Permeability
Drug Resistance, Bacterial
Gene Deletion
Glucose
Glycerol
Lipids
Mycobacterium tuberculosis
Sulfhydryl Compounds
The pan-genome effector-triggered immunity landscape of a host-pathogen interaction
期刊论文
, 2020, 卷号: 367, 期号: 6479
作者:
Laflamme B.
;
Dillon M.M.
;
Martel A.
;
Almeida R.N.D.
;
Desveaux D.
;
Guttman D.S.
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2020/07/28
genome
herb
host-pathogen interaction
immunity
microbial ecology
protein
virulence
allele
Arabidopsis thaliana
article
host pathogen interaction
immunity
major clinical study
nonhuman
orthology
Pseudomonas syringae
Arabidopsis thaliana
Pseudomonas syringae
De novo protein design enables the precise induction of RSV-neutralizing antibodies
期刊论文
, 2020, 卷号: 368, 期号: 6492
作者:
Sesterhenn F.
;
Yang C.
;
Bonet J.
;
Cramer J.T.
;
Wen X.
;
Wang Y.
;
Chiang C.-I.
;
Abriata L.A.
;
Kucharska I.
;
Castoro G.
;
Vollers S.S.
;
Galloux M.
;
Dheilly E.
;
Rosset S.
;
Corthésy P.
;
Georgeon S.
;
Villard M.
;
Richard C.-A.
;
Descamps D.
;
Delgado T.
;
Oricchio E.
;
Rameix-Welti M.-A.
;
Más V.
;
Ervin S.
;
Eléouët J.-F.
;
Riffault S.
;
Bates J.T.
;
Julien J.-P.
;
Li Y.
;
Jardetzky T.
;
Krey T.
;
Correia B.E.
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2020/07/28
algorithm
antibody
design
neutralization
protein
vaccine
Mus
Primates
Respiratory syncytial virus
Rice stripe virus
epitope
fusion protein
nanobody
neutralizing antibody
respiratory syncytial virus vaccine
biology
biosynthesis
chemistry
human
Human respiratory syncytial virus
immunology
procedures
protein conformation
protein engineering
protein motif
Amino Acid Motifs
Antibodies, Neutralizing
Computational Biology
Humans
Immunodominant Epitopes
Protein Conformation
Protein Engineering
Recombinant Fusion Proteins
Respiratory Syncytial Virus Vaccines
Respiratory Syncytial Virus, Human
Single-Domain Antibodies
Natural hybridization reveals incompatible alleles that cause melanoma in swordtail fish
期刊论文
, 2020, 卷号: 368, 期号: 6492
作者:
Powell D.L.
;
García-Olazábal M.
;
Keegan M.
;
Reilly P.
;
Du K.
;
Díaz-Loyo A.P.
;
Banerjee S.
;
Blakkan D.
;
Reich D.
;
Andolfatto P.
;
Rosenthal G.G.
;
Schartl M.
;
Schumer M.
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2020/07/28
allele
cyprinid
hybrid
hybridization
new species
reproductive status
skin disorder
survival
Vertebrata
fish protein
protein tyrosine kinase
Xmrk protein, Xiphophorus
allele
animal
chimera
Cyprinodontiformes
fin (organ)
fish disease
gene locus
genetics
genome-wide association study
hybridization
melanoma
pathology
virology
Alleles
Animal Fins
Animals
Chimera
Cyprinodontiformes
Fish Diseases
Fish Proteins
Genetic Loci
Genome-Wide Association Study
Hybridization, Genetic
Melanoma
Receptor Protein-Tyrosine Kinases