气候变化领域集成服务门户(CCPortal): Natural hybridization reveals incompatible alleles that cause melanoma in swordtail fish

CCPortal

DOI	10.1126/science.aba5216
	Natural hybridization reveals incompatible alleles that cause melanoma in swordtail fish
	Powell D.L.; García-Olazábal M.; Keegan M.; Reilly P.; Du K.; Díaz-Loyo A.P.; Banerjee S.; Blakkan D.; Reich D.; Andolfatto P.; Rosenthal G.G.; Schartl M.; Schumer M.
发表日期	2020
ISSN	0036-8075
起始页码	731
结束页码	736
卷号	368 期号:6492
英文摘要	The establishment of reproductive barriers between populations can fuel the evolution of new species. A genetic framework for this process posits that “incompatible” interactions between genes can evolve that result in reduced survival or reproduction in hybrids. However, progress has been slow in identifying individual genes that underlie hybrid incompatibilities. We used a combination of approaches to map the genes that drive the development of an incompatibility that causes melanoma in swordtail fish hybrids. One of the genes involved in this incompatibility also causes melanoma in hybrids between distantly related species. Moreover, this melanoma reduces survival in the wild, likely because of progressive degradation of the fin. This work identifies genes underlying a vertebrate hybrid incompatibility and provides a glimpse into the action of these genes in natural hybrid populations. © 2020 American Association for the Advancement of Science. All rights reserved.
关键词	allele cyprinid hybrid hybridization new species reproductive status skin disorder survival Vertebrata fish protein protein tyrosine kinase Xmrk protein, Xiphophorus allele animal chimera Cyprinodontiformes fin (organ)fish disease gene locus genetics genome-wide association study hybridization melanoma pathology virology Alleles Animal Fins Animals Chimera Cyprinodontiformes Fish Diseases Fish Proteins Genetic Loci Genome-Wide Association Study Hybridization, Genetic Melanoma Receptor Protein-Tyrosine Kinases
语种	英语
来源机构	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/133494
推荐引用方式 GB/T 7714	Powell D.L.,García-Olazábal M.,Keegan M.,et al. Natural hybridization reveals incompatible alleles that cause melanoma in swordtail fish[J]. Science,2020,368(6492).
APA	Powell D.L..,García-Olazábal M..,Keegan M..,Reilly P..,Du K..,...&Schumer M..(2020).Natural hybridization reveals incompatible alleles that cause melanoma in swordtail fish.,368(6492).
MLA	Powell D.L.,et al."Natural hybridization reveals incompatible alleles that cause melanoma in swordtail fish".368.6492(2020).