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Computing cancer's weak spots 期刊论文
, 2020, 卷号: 368, 期号: 6496
作者:  Khamsi R.
收藏  |  浏览/下载：31/0  |  提交时间：2020/07/28
ruxolitinib  STAT3 protein  antineoplastic agent  transcription factor  algorithm  cancer  computer simulation  disease treatment  drug development  medicine  Article  cancer cell  cancer radiotherapy  enzyme inhibition  gene activity  gene expression regulation  gene interaction  gene mutation  gene repression  gene targeting  human  laboratory test  malignant neoplasm  molecular dynamics  nonhuman  oncologist  priority journal  RNA sequencing  algorithm  genetics  mutation  neoplasm  personalized medicine  procedures  systems biology  Algorithms  Antineoplastic Agents  Humans  Mutation  Neoplasms  Precision Medicine  Systems Biology  Transcription Factors  
Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells 期刊论文
, 2020, 卷号: 368, 期号: 6494
作者:  Zhou Z.;  He H.;  Wang K.;  Shi X.;  Wang Y.;  Su Y.;  Wang Y.;  Li D.;  Liu W.;  Zhang Y.;  Shen L.;  Han W.;  Shen L.;  Ding J.;  Shao F.
收藏  |  浏览/下载：26/0  |  提交时间：2020/07/28
cell  cell component  cytology  enzyme  enzyme activity  gene expression  immunity  tumor  Mus  gamma interferon  granzyme  GSDMB protein, human  GZMA protein, human  pore forming cytotoxic protein  tumor protein  animal  Bagg albino mouse  chemistry  cytotoxic T lymphocyte  enzymology  genetics  HEK293 cell line  human  immunology  metabolism  mouse  natural killer cell  neoplasm  pathology  protein degradation  protein domain  pyroptosis  transgenic mouse  Animals  Granzymes  HEK293 Cells  Humans  Interferon-gamma  Killer Cells, Natural  Mice  Mice, Inbred BALB C  Mice, Transgenic  Neoplasm Proteins  Neoplasms  Pore Forming Cytotoxic Proteins  Protein Domains  Proteolysis  Pyroptosis  T-Lymphocytes, Cytotoxic  
Mechanisms generating cancer genome complexity from a single cell division error 期刊论文
, 2020, 卷号: 368, 期号: 6488
作者:  Umbreit N.T.;  Zhang C.-Z.;  Lynch L.D.;  Blaine L.J.;  Cheng A.M.;  Tourdot R.;  Sun L.;  Almubarak H.F.;  Judge K.;  Mitchell T.J.;  Spektor A.;  Pellman D.
收藏  |  浏览/下载：10/0  |  提交时间：2020/07/28
myosin adenosine triphosphatase  cancer  chromosome  detection method  DNA  error correction  gene expression  genome  genomics  mutation  Article  cell division  cellular, subcellular and molecular biological phenomena and functions  chromosome breakage  chromosome breakage fusion bridge  chromosome bridge formation  chromosomes and chromosomal phenomena  chromothripsis  DNA damage  DNA replication  human  interphase  malignant neoplasm  micronucleus  mitosis  oncogenomics  priority journal  single cell division error  
Deregulation of ribosomal protein expression and translation promotes breast cancer metastasis 期刊论文
, 2020, 卷号: 367, 期号: 6485
作者:  Ebright R.Y.;  Lee S.;  Wittner B.S.;  Niederhoffer K.L.;  Nicholson B.T.;  Bardia A.;  Truesdell S.;  Wiley D.F.;  Wesley B.;  Li S.;  Mai A.;  Aceto N.;  Vincent-Jordan N.;  Szabolcs A.;  Chirn B.;  Kreuzer J.;  Comaills V.;  Kalinich M.;  Haas W.;  Ting D.T.;  Toner M.;  Vasudevan S.;  Haber D.A.;  Maheswaran S.;  Micalizzi D.S.
收藏  |  浏览/下载：43/0  |  提交时间：2020/07/28
CRISPR associated protein  epidermal growth factor receptor 2  Ki 67 antigen  ribosome protein  ribosome RNA  transcription factor E2F  ribosome protein  cancer  cell  gene expression  genetic engineering  protein  RNA  tumor  animal experiment  animal model  animal tissue  Article  biogenesis  bioluminescence  breast cancer  cell cycle progression  cell cycle regulation  cell proliferation  circulating tumor cell  controlled study  enzyme activation  epithelial mesenchymal transition  gene expression profiling  genetic transcription  human  human cell  lung metastasis  metastasis  microfluidics  mouse  nonhuman  overall survival  phenotype  priority journal  progression free survival  promoter region  protein expression  protein processing  protein synthesis  proteomics  RNA sequence  transcription regulation  animal  breast tumor  cancer transplantation  CRISPR Cas system  female  gene expression regulation  genetics  pathology  sequence analysis  tumor cell line  tumor embolism  Mus  Animals  Breast Neoplasms  Cell Line, Tumor  CRISPR-Cas Systems  Female  Gene Expression Regulation, Neoplastic  Humans  Mice  Neoplasm Metastasis  Neoplasm Transplantation  Neoplastic Cells, Circulating  Ribosomal Proteins  Sequence Analysis, RNA  
Structure of nucleosome-bound human BAF complex 期刊论文
, 2020, 卷号: 367, 期号: 6480
作者:  He S.;  Wu Z.;  Tian Y.;  Yu Z.;  Yu J.;  Wang X.;  Li J.;  Liu B.;  Xu Y.
收藏  |  浏览/下载：28/0  |  提交时间：2020/07/28
actin related protein  adenosine triphosphatase  BRG1 BRM associated factor  DNA  multiprotein complex  protein SWI  retinoblastoma binding protein 2  SMARCC protein  SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily B member 1  transcription factor  transcription factor SNF  unclassified drug  cancer  enzyme activity  gene expression  hydrolysis  mutation  protein  alpha helix  Article  carboxy terminal sequence  cell interaction  cryoelectron microscopy  disease association  human  malignant neoplasm  molecular recognition  mutation  nucleosome  priority journal  protein function  protein hydrolysis  protein structure  structure analysis  Mammalia  
Massively multiplex chemical transcriptomics at single-cell resolution 期刊论文
, 2020, 卷号: 367, 期号: 6473
作者:  Srivatsan S.R.;  McFaline-Figueroa J.L.;  Ramani V.;  Saunders L.;  Cao J.;  Packer J.;  Pliner H.A.;  Jackson D.L.;  Daza R.M.;  Christiansen L.;  Zhang F.;  Steemers F.;  Shendure J.;  Trapnell C.
收藏  |  浏览/下载：13/0  |  提交时间：2020/07/28
4 (2 aminoethylamino) 1,8 dimethylimidazo[1,2 a]quinoxaline  abexinostat  acetic acid  belinostat  cudc 101  fimepinostat  givinostat  histone deacetylase inhibitor  m 344  n [2 [3 (1 piperazinylmethyl)imidazo[2,1 b]thiazol 6 yl]phenyl] 2 quinoxalinecarboxamide  panobinostat  pracinostat  rec 2282  trametinib  transcriptome  trichostatin A  unclassified drug  transcriptome  cancer  cell  chemical analysis  detection method  experimental study  genetic analysis  resolution  A-549 cell line  animal cell  animal experiment  Article  cell function  cell heterogeneity  cell labeling  cell proliferation  chromatin  controlled study  dose response  drug activity  experimentation  gene control  genetic transcription  human  human cell  K-562 cell line  MCF-7 cell line  mouse  nonhuman  pilot study  priority journal  proof of concept  RNA sequence  screening  single cell analysis  transcriptomics  cell nucleus  drug effect  genetics  genomics  high throughput screening  metabolism  neoplasm  procedures  single cell analysis  A549 Cells  Acetates  Cell Nucleus  Chromatin  Genomics  High-Throughput Screening Assays  Histone Deacetylase Inhibitors  Humans  K562 Cells  MCF-7 Cells  Neoplasms  RNA-Seq  Single-Cell Analysis  Transcriptome  
Regenerative potential of prostate luminal cells revealed by single-cell analysis 期刊论文
, 2020, 卷号: 368, 期号: 6490
作者:  Karthaus W.R.;  Hofree M.;  Choi D.;  Linton E.L.;  Turkekul M.;  Bejnood A.;  Carver B.;  Gopalan A.;  Abida W.;  Laudone V.;  Biton M.;  Chaudhary O.;  Xu T.;  Masilionis I.;  Manova K.;  Mazutis L.;  Pe’er D.;  Regev A.;  Sawyers C.L.
收藏  |  浏览/下载：90/0  |  提交时间：2020/07/28
androgen  growth factor  Nrg2 growth factor  Rspo3 growth factor  unclassified drug  androgen binding protein  antiandrogen  ataxin 1  Atxn1 protein, mouse  glycosylphosphatidylinositol anchored protein  homeodomain protein  nerve growth factor  Nkx3-1 protein, mouse  Nrg2 protein, mouse  probasin  Psca protein, mouse  R-spondin3 protein, mouse  thrombospondin  transcription factor  tumor antigen  tumor protein  androgen  cancer  cell  gene expression  RNA  rodent  ablation therapy  animal cell  animal tissue  Article  cell differentiation  cell population  cell regeneration  cells by body anatomy  controlled study  gene  gene expression  human  luminal cell  male  mesenchyme cell  mouse  nonhuman  paracrine signaling  priority journal  prostate cell  prostate tissue  protein expression  Psca gene  RNA sequencing  Sca1 gene  single cell analysis  animal  genetics  mesenchymal stem cell  metabolism  organ size  organoid  physiology  prostate  prostate tumor  regeneration  sequence analysis  single cell analysis  Mus  Androgen Antagonists  Androgen-Binding Protein  Androgens  Animals  Antigens, Neoplasm  Ataxin-1  Cell Differentiation  Gene Expression  GPI-Linked Proteins  Homeodomain Proteins  Humans  Male  Mesenchymal Stem Cells  Mice  Neoplasm Proteins  Nerve Growth Factors  Organ Size  Organoids  Prostate  Prostatic Neoplasms  Regeneration  Sequence Analysis, RNA  Single-Cell Analysis  Thrombospondins  Transcription Factors  
The integrated stress response: From mechanism to disease 期刊论文
, 2020, 卷号: 368, 期号: 6489
作者:  [无可用作者姓名]
收藏  |  浏览/下载：20/0  |  提交时间：2020/07/28
initiation factor 2  cell component  cognition  disease  homeostasis  protein  quality control  5' untranslated region  adulthood  Article  cell reprogramming technique  cellular stress response  cognitive defect  diabetes mellitus  disease activity  eukaryotic cell  gene expression  human  long term memory  malignant neoplasm  metabolic disorder  nerve degeneration  nonhuman  oxidative stress  pathogenesis  phosphorylation  priority journal  protein defect  protein homeostasis  RNA translation  signal transduction  translation initiation  virus infection  
Feasibility of blood testing combined with PET-CT to screen for cancer and guide intervention 期刊论文
, 2020, 卷号: 369, 期号: 6499
作者:  Lennon A.M.;  Buchanan A.H.;  Kinde I.;  Warren A.;  Honushefsky A.;  Cohain A.T.;  Ledbetter D.H.;  Sanfilippo F.;  Sheridan K.;  Rosica D.;  Adonizio C.S.;  Hwang H.J.;  Lahouel K.;  Cohen J.D.;  Douville C.;  Patel A.A.;  Hagmann L.N.;  Rolston D.D.;  Malani N.;  Zhou S.;  Bettegowda C.;  Diehl D.L.;  Urban B.;  Still C.D.;  Kann L.;  Woods J.I.;  Salvati Z.M.;  Vadakara J.;  Leeming R.;  Bhattacharya P.;  Walter C.;  Parker A.;  Lengauer C.;  Klein A.;  Tomasetti C.;  Fishman E.K.;  Hruban R.H.;  Kinzler K.W.;  Vogelstein B.;  Papadopoulos N.
收藏  |  浏览/下载：30/0  |  提交时间：2020/07/28
aged  blood  blood examination  cohort analysis  diagnostic imaging  early cancer diagnosis  female  human  mass screening  neoplasm  positron emission tomography-computed tomography  procedures  Aged  Cohort Studies  Early Detection of Cancer  Female  Hematologic Tests  Humans  Mass Screening  Neoplasms  Positron Emission Tomography Computed Tomography  
An RNA vaccine drives expansion and efficacy of claudin-CAR-T cells against solid tumors 期刊论文
, 2020, 卷号: 367, 期号: 6476
作者:  Reinhard K.;  Rengstl B.;  Oehm P.;  Michel K.;  Billmeier A.;  Hayduk N.;  Klein O.;  Kuna K.;  Ouchan Y.;  Wöll S.;  Christ E.;  Weber D.;  Suchan M.;  Bukur T.;  Birtel M.;  Jahndel V.;  Mroz K.;  Hobohm K.;  Kranz L.;  Diken M.;  Kühlcke K.;  Türeci Ö.;  Sahin U.
收藏  |  浏览/下载：34/0  |  提交时间：2020/07/28
chimeric antigen receptor  claudin 6  RNA vaccine  antigen  cell component  protein  RNA  tumor  vaccine  animal cell  animal experiment  animal model  animal tissue  antigen presenting cell  antineoplastic activity  Article  cell stimulation  cell transport  chimeric antigen receptor T-cell immunotherapy  controlled study  drug efficacy  human  human cell  in vivo study  mouse  nonhuman  phenotype  priority journal  real time polymerase chain reaction  solid malignant neoplasm  therapy effect  vaccination coverage