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| DOI | 10.1126/science.abb9601 |
| Feasibility of blood testing combined with PET-CT to screen for cancer and guide intervention | |
| Lennon A.M.; Buchanan A.H.; Kinde I.; Warren A.; Honushefsky A.; Cohain A.T.; Ledbetter D.H.; Sanfilippo F.; Sheridan K.; Rosica D.; Adonizio C.S.; Hwang H.J.; Lahouel K.; Cohen J.D.; Douville C.; Patel A.A.; Hagmann L.N.; Rolston D.D.; Malani N.; Zhou S.; Bettegowda C.; Diehl D.L.; Urban B.; Still C.D.; Kann L.; Woods J.I.; Salvati Z.M.; Vadakara J.; Leeming R.; Bhattacharya P.; Walter C.; Parker A.; Lengauer C.; Klein A.; Tomasetti C.; Fishman E.K.; Hruban R.H.; Kinzler K.W.; Vogelstein B.; Papadopoulos N. | |
| 发表日期 | 2020 |
| ISSN | 10959203 |
| 卷号 | 369期号:6499 |
| 英文摘要 | Cancer treatments are often more successful when the disease is detected early. We evaluated the feasibility and safety of multicancer blood testing coupled with positron emission tomography-computed tomography (PET-CT) imaging to detect cancer in a prospective, interventional study of 10,006 women not previously known to have cancer. Positive blood tests were independently confirmed by a diagnostic PET-CT, which also localized the cancer. Twenty-six cancers were detected by blood testing. Of these, 15 underwent PET-CT imaging and nine (60%) were surgically excised. Twenty-four additional cancers were detected by standard-of-care screening and 46 by neither approach. One percent of participants underwent PET-CT imaging based on false-positive blood tests, and 0.22% underwent a futile invasive diagnostic procedure. These data demonstrate that multicancer blood testing combined with PET-CT can be safely incorporated into routine clinical care, in some cases leading to surgery with intent to cure. Copyright © 2020, American Association for the Advancement of Science. |
| 关键词 | agedbloodblood examinationcohort analysisdiagnostic imagingearly cancer diagnosisfemalehumanmass screeningneoplasmpositron emission tomography-computed tomographyproceduresAgedCohort StudiesEarly Detection of CancerFemaleHematologic TestsHumansMass ScreeningNeoplasmsPositron Emission Tomography Computed Tomography |
| 语种 | 英语 |
| 来源机构 | Science (New York, N.Y.) |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/133384 |
| 推荐引用方式 GB/T 7714 | Lennon A.M.,Buchanan A.H.,Kinde I.,et al. Feasibility of blood testing combined with PET-CT to screen for cancer and guide intervention[J]. Science (New York, N.Y.),2020,369(6499). |
| APA | Lennon A.M..,Buchanan A.H..,Kinde I..,Warren A..,Honushefsky A..,...&Papadopoulos N..(2020).Feasibility of blood testing combined with PET-CT to screen for cancer and guide intervention.,369(6499). |
| MLA | Lennon A.M.,et al."Feasibility of blood testing combined with PET-CT to screen for cancer and guide intervention".369.6499(2020). |
| 条目包含的文件 | 条目无相关文件。 | |||||
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