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| DOI | 10.1126/science.aba0712 |
| Mechanisms generating cancer genome complexity from a single cell division error | |
| Umbreit N.T.; Zhang C.-Z.; Lynch L.D.; Blaine L.J.; Cheng A.M.; Tourdot R.; Sun L.; Almubarak H.F.; Judge K.; Mitchell T.J.; Spektor A.; Pellman D. | |
| 发表日期 | 2020 |
| ISSN | 0036-8075 |
| 卷号 | 368期号:6488 |
| 英文摘要 | The chromosome breakage-fusion-bridge (BFB) cycle is a mutational process that produces gene amplification and genome instability. Signatures of BFB cycles can be observed in cancer genomes alongside chromothripsis, another catastrophic mutational phenomenon. We explain this association by elucidating a mutational cascade that is triggered by a single cell division error-chromosome bridge formation-that rapidly increases genomic complexity. We show that actomyosin forces are required for initial bridge breakage. Chromothripsis accumulates, beginning with aberrant interphase replication of bridge DNA. A subsequent burst of DNA replication in the next mitosis generates extensive DNA damage. During this second cell division, broken bridge chromosomes frequently missegregate and form micronuclei, promoting additional chromothripsis. We propose that iterations of this mutational cascade generate the continuing evolution and subclonal heterogeneity characteristic of many human cancers. © 2020 American Association for the Advancement of Science. All rights reserved. |
| 关键词 | myosin adenosine triphosphatasecancerchromosomedetection methodDNAerror correctiongene expressiongenomegenomicsmutationArticlecell divisioncellular, subcellular and molecular biological phenomena and functionschromosome breakagechromosome breakage fusion bridgechromosome bridge formationchromosomes and chromosomal phenomenachromothripsisDNA damageDNA replicationhumaninterphasemalignant neoplasmmicronucleusmitosisoncogenomicspriority journalsingle cell division error |
| 语种 | 英语 |
| 来源机构 | Science |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/133567 |
| 推荐引用方式 GB/T 7714 | Umbreit N.T.,Zhang C.-Z.,Lynch L.D.,et al. Mechanisms generating cancer genome complexity from a single cell division error[J]. Science,2020,368(6488). |
| APA | Umbreit N.T..,Zhang C.-Z..,Lynch L.D..,Blaine L.J..,Cheng A.M..,...&Pellman D..(2020).Mechanisms generating cancer genome complexity from a single cell division error.,368(6488). |
| MLA | Umbreit N.T.,et al."Mechanisms generating cancer genome complexity from a single cell division error".368.6488(2020). |
| 条目包含的文件 | 条目无相关文件。 | |||||
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