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Liquid-liquid phase separation drives skin barrier formation 期刊论文
, 2020, 卷号: 367, 期号: 6483
作者:  Quiroz F.G.;  Fiore V.F.;  Levorse J.;  Polak L.;  Wong E.;  Pasolli H.A.;  Fuchs E.
收藏  |  浏览/下载：24/0  |  提交时间：2020/07/28
filaggrin  keratohyalin  coalescence  differentiation  separation  skin  skin disorder  stratification  amino acid composition  Article  bioengineering  biophysics  cell differentiation  cell function  cell structure  epidermis cell  genetic transfection  human  keratinocyte  liquid  live cell imaging  molecular dynamics  nonhuman  pH  phase separation  phase transition  priority journal  proteomics  sequence analysis  signal transduction  skin  skin surface  Mus  
Valence and patterning of aromatic residues determine the phase behavior of prion-like domains 期刊论文
, 2020, 卷号: 367, 期号: 6478
作者:  Martin E.W.;  Holehouse A.S.;  Peran I.;  Farag M.;  Incicco J.J.;  Bremer A.;  Grace C.R.;  Soranno A.;  Pappu R.V.;  Mittag T.
收藏  |  浏览/下载：16/0  |  提交时间：2020/07/28
aromatic hydrocarbon  biophysics  concentration (composition)  genetic analysis  nuclear magnetic resonance  prion disease  protein  separation  temperature effect  article  nonhuman  nuclear magnetic resonance spectroscopy  phase separation  prediction  prion  simulation  X ray crystallography  amino acid sequence  chemistry  phase transition  prion  protein domain  small angle scattering  X ray diffraction  heterogeneous nuclear ribonucleoprotein A1  phenylalanine  tyrosine  Amino Acid Sequence  Heterogeneous Nuclear Ribonucleoprotein A1  Magnetic Resonance Spectroscopy  Phase Transition  Phenylalanine  Prions  Protein Domains  Scattering, Small Angle  Tyrosine  X-Ray Diffraction  
A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV 期刊论文
, 2020, 卷号: 368, 期号: 6491
作者:  Yuan M.;  Wu N.C.;  Zhu X.;  Lee C.-C.D.;  So R.T.Y.;  Lv H.;  Mok C.K.P.;  Wilson I.A.
收藏  |  浏览/下载：17/0  |  提交时间：2020/07/28
angiotensin converting enzyme 2  epitope  neutralizing antibody  virus hemagglutinin  virus spike protein  angiotensin converting enzyme 2  coronavirus receptors  coronavirus spike glycoprotein  dipeptidyl carboxypeptidase  epitope  neutralizing antibody  spike glycoprotein, SARS-CoV  spike protein, SARS-CoV-2  virus antibody  virus antigen  virus receptor  antibody  antigen  chemical binding  crystal structure  protein  respiratory disease  viral disease  virus  amino terminal sequence  antibody isolation  antigen binding  antigenicity  Article  binding affinity  binding site  conservation biology  controlled study  coronavirus disease 2019  cross reaction  cryoelectron microscopy  crystal structure  enzyme linked immunosorbent assay  epidemic  glycosylation  human  hydrophobicity  immune response  in vitro study  in vivo study  light chain  nonhuman  priority journal  protein conformation  protein domain  protein interaction  protein localization  protein structure  protein targeting  receptor binding  SARS coronavirus  Severe acute respiratory syndrome coronavirus 2  amino acid sequence  antibody affinity  Betacoronavirus  binding site  chemistry  immunology  metabolism  molecular model  SARS coronavirus  X ray crystallography  Coronavirus  SARS coronavirus  Amino Acid Sequence  Antibodies, Neutralizing  Antibodies, Viral  Antibody Affinity  Antigens, Viral  Betacoronavirus  Binding Sites  Cross Reactions  Crystallography, X-Ray  Epitopes  Models, Molecular  Peptidyl-Dipeptidase A  Protein Conformation  Protein Domains  Protein Interaction Domains and Motifs  Receptors, Virus  SARS Virus  Spike Glycoprotein, Coronavirus  
Dopaminylation of histone H3 in ventral tegmental area regulates cocaine seeking 期刊论文
, 2020, 卷号: 368, 期号: 6487
作者:  Lepack A.E.;  Werner C.T.;  Stewart A.F.;  Fulton S.L.;  Zhong P.;  Farrelly L.A.;  Smith A.C.W.;  Ramakrishnan A.;  Lyu Y.;  Bastle R.M.;  Martin J.A.;  Mitra S.;  O'Connor R.M.;  Wang Z.-J.;  Molina H.;  Turecki G.;  Shen L.;  Yan Z.;  Calipari E.S.;  Dietz D.M.;  Kenny P.J.;  Maze I.
收藏  |  浏览/下载：35/0  |  提交时间：2020/07/28
amidase  dopamine  histone H3  histone transamidase  protein glutamine gamma glutamyltransferase 2  RNA  unclassified drug  brain  cell  chemical compound  chemical reaction  gene expression  genetic analysis  protein  action potential  amino acid substitution  amino terminal sequence  Article  cocaine dependence  controlled study  dopamine release  dopaminergic nerve cell  dopaminergic transmission  down regulation  drug seeking behavior  enzyme activity  gene expression  histone dopaminylation  histone modification  human  human tissue  hyperpolarization  in vitro study  motivation  nerve cell plasticity  nerve projection  neuropathology  nucleus accumbens  priority journal  protein expression  protein function  reward  RNA sequence  ventral tegmentum  Rattus  
Ancient origins of allosteric activation in a Ser-Thr kinase 期刊论文
, 2020, 卷号: 367, 期号: 6480
作者:  Hadzipasic A.;  Wilson C.;  Nguyen V.;  Kern N.;  Kim C.;  Pitsawong W.;  Villali J.;  Zheng Y.;  Kern D.
收藏  |  浏览/下载：36/0  |  提交时间：2020/07/28
aurora A kinase  microtubule associated protein  TPX2 protein  unclassified drug  activation energy  ancestry  cell  chemical binding  experimental study  fitness  protein  allosterism  amino acid sequence  Article  binding affinity  binding site  enzyme activation  enzyme activity  enzyme binding  enzyme localization  enzyme phosphorylation  gene duplication  horizontal gene transfer  human  hydrophobicity  intracellular signaling  phylogenetic tree  phylogeny  priority journal  protein binding  protein localization  protein protein interaction  
Protein-coding changes preceded cis-regulatory gains in a newly evolved transcription circuit 期刊论文
, 2020, 卷号: 367, 期号: 6473
作者:  Britton C.S.;  Sorrells T.R.;  Johnson A.D.
收藏  |  浏览/下载：12/0  |  提交时间：2020/07/28
DNA binding protein  fungal protein  homeodomain protein  Matalpha2 protein  regulator protein  transcription factor  unclassified drug  gene  gene expression  protein  amino acid sequence  Article  cladistics  controlled study  gene deletion  gene expression regulation  gene repression  gene sequence  gene structure  molecular evolution  nonhuman  priority journal  protein DNA binding  protein function  protein structure  Saccharomycotina  sequence homology  species  transcription regulation  Wickerhamomyces anomalus  Fungi  
Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved a-ketoamide inhibitors 期刊论文
, 2020, 卷号: 368, 期号: 6489
作者:  Zhang L.;  Lin D.;  Sun X.;  Curth U.;  Drosten C.;  Sauerhering L.;  Becker S.;  Rox K.;  Hilgenfeld R.
收藏  |  浏览/下载：28/0  |  提交时间：2020/07/28
alanine  alpha ketoamide inhibitor  antivirus agent  isoleucine  leucine  proteinase  Severe acute respiratory syndrome coronavirus 2 main protease  threonine  unclassified drug  crystal structure  drug  enzyme  enzyme activity  inhibitor  reaction kinetics  amino acid sequence  animal cell  animal experiment  animal tissue  antiviral activity  Article  catalysis  catalytic efficiency  controlled study  crystal structure  dimerization  dissociation constant  drug clearance  drug design  drug distribution  drug half life  drug potency  drug protein binding  drug solubility  drug structure  EC50  enzyme inhibition  human  human cell  hydrogen bond  hydrophobicity  IC50  maximum concentration  mean residence time  metabolic stability  mouse  nonhuman  priority journal  protein structure  RNA replication  SARS coronavirus  Severe acute respiratory syndrome coronavirus 2  viral tropism  virus inhibition  Coronavirus  SARS coronavirus  
Structure of CD20 in complex with the therapeutic monoclonal antibody rituximab 期刊论文
, 2020, 卷号: 367, 期号: 6483
作者:  Rougé L.;  Chiang N.;  Steffek M.;  Kugel C.;  Croll T.I.;  Tam C.;  Estevez A.;  Arthur C.P.;  Koth C.M.;  Ciferri C.;  Kraft E.;  Payandeh J.;  Nakamura G.;  Koerber J.T.;  Rohou A.
收藏  |  浏览/下载：14/0  |  提交时间：2020/07/28
CD20 antigen  dimer  epitope  Fc receptor  immunoglobulin F(ab) fragment  obinutuzumab  ocrelizumab  ofatumumab  rituximab  tositumomab i 131  antibody  antigen  cell  chemical binding  composite  gene expression  genetic marker  protein  amino acid sequence  antibody dependent cellular cytotoxicity  antigen antibody complex  antigen binding  antigen structure  Article  cell death  cell surface  chemical bond  complement dependent cytotoxicity  drug protein binding  drug targeting  electron microscopy  human  humoral immune deficiency  insect cell  lipid raft  malignant neoplasm  molecular recognition  multiple sclerosis  nonhuman  phagocytosis  priority journal  protein cross linking  protein interaction  stoichiometry  surface plasmon resonance  
Ion transport and regulation in a synaptic vesicle glutamate transporter 期刊论文
, 2020, 卷号: 368, 期号: 6493
作者:  Li F.;  Eriksen J.;  Finer-Moore J.;  Chang R.;  Nguyen P.;  Bowen A.;  Myasnikov A.;  Yu Z.;  Bulkley D.;  Cheng Y.;  Edwards R.H.;  Stroud R.M.
收藏  |  浏览/下载：32/0  |  提交时间：2020/07/28
brain  chemical binding  chloride  neurology  substrate  Rattus  chloride  chloride channel  glutamic acid  Slc17a6 protein, rat  vesicular glutamate transporter 2  allosterism  amino acid sequence  animal  binding site  chemistry  cryoelectron microscopy  ion transport  membrane potential  metabolism  pH  protein domain  rat  synapse vesicle  Allosteric Regulation  Amino Acid Sequence  Animals  Binding Sites  Chloride Channels  Chlorides  Cryoelectron Microscopy  Glutamic Acid  Hydrogen-Ion Concentration  Ion Transport  Membrane Potentials  Protein Domains  Rats  Synaptic Vesicles  Vesicular Glutamate Transport Protein 2  
Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2 期刊论文
, 2020, 卷号: 367, 期号: 6485
作者:  Yan R.;  Zhang Y.;  Li Y.;  Xia L.;  Guo Y.;  Zhou Q.
收藏  |  浏览/下载：17/0  |  提交时间：2020/07/28
angiotensin converting enzyme 2  coronavirus spike glycoprotein  heterodimer  homodimer  amino acid transporter  angiotensin converting enzyme 2  dipeptidyl carboxypeptidase  protein binding  SLC6A19 protein, human  spike protein, SARS-CoV-2  virus receptor  enzyme  gene  gene expression  protein  ultrastructure  virus  Article  binding site  complex formation  controlled study  coronavirus disease 2019  cryoelectron microscopy  dimerization  embryo  enzyme structure  human  human cell  nonhuman  priority journal  protein domain  SARS-related coronavirus  Severe acute respiratory syndrome coronavirus 2  amino acid sequence  Betacoronavirus  Coronavirus infection  molecular model  pandemic  protein multimerization  SARS coronavirus  sequence alignment  ultrastructure  virus pneumonia  Coronavirus  SARS coronavirus  Amino Acid Sequence  Amino Acid Transport Systems, Neutral  Betacoronavirus  Coronavirus Infections  Cryoelectron Microscopy  Humans  Models, Molecular  Pandemics  Peptidyl-Dipeptidase A  Pneumonia, Viral  Protein Binding  Protein Domains  Protein Multimerization  Receptors, Virus  SARS Virus  Sequence Alignment  Spike Glycoprotein, Coronavirus