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DOI | 10.1126/science.aax5217 |
Protein-coding changes preceded cis-regulatory gains in a newly evolved transcription circuit | |
Britton C.S.; Sorrells T.R.; Johnson A.D. | |
发表日期 | 2020 |
ISSN | 0036-8075 |
起始页码 | 96 |
结束页码 | 100 |
卷号 | 367期号:6473 |
英文摘要 | Changes in both the coding sequence of transcriptional regulators and in the cis-regulatory sequences recognized by these regulators have been implicated in the evolution of transcriptional circuits. However, little is known about how they evolved in concert. We describe an evolutionary pathway in fungi where a new transcriptional circuit (a-specific gene repression by the homeodomain protein Mata2) evolved by coding changes in this ancient regulator, followed millions of years later by cis-regulatory sequence changes in the genes of its future regulon. By analyzing a group of species that has acquired the coding changes but not the cis-regulatory sites, we show that the coding changes became necessary for the regulator's deeply conserved function, thereby poising the regulator to jump-start formation of the new circuit. © 2020 American Association for the Advancement of Science. All rights reserved. |
关键词 | DNA binding proteinfungal proteinhomeodomain proteinMatalpha2 proteinregulator proteintranscription factorunclassified druggenegene expressionproteinamino acid sequenceArticlecladisticscontrolled studygene deletiongene expression regulationgene repressiongene sequencegene structuremolecular evolutionnonhumanpriority journalprotein DNA bindingprotein functionprotein structureSaccharomycotinasequence homologyspeciestranscription regulationWickerhamomyces anomalusFungi |
语种 | 英语 |
来源机构 | Science |
文献类型 | 期刊论文 |
条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/133816 |
推荐引用方式 GB/T 7714 | Britton C.S.,Sorrells T.R.,Johnson A.D.. Protein-coding changes preceded cis-regulatory gains in a newly evolved transcription circuit[J]. Science,2020,367(6473). |
APA | Britton C.S.,Sorrells T.R.,&Johnson A.D..(2020).Protein-coding changes preceded cis-regulatory gains in a newly evolved transcription circuit.,367(6473). |
MLA | Britton C.S.,et al."Protein-coding changes preceded cis-regulatory gains in a newly evolved transcription circuit".367.6473(2020). |
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