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Human CNS barrier-forming organoids with cerebrospinal fluid production 期刊论文
, 2020, 卷号: 369, 期号: 6500
作者:  Pellegrini L.;  Bonfio C.;  Chadwick J.;  Begum F.;  Skehel M.;  Lancaster M.A.
收藏  |  浏览/下载:28/0  |  提交时间:2020/07/28
blood brain barrier  cell culture technique  cerebrospinal fluid  choroid plexus  gene expression profiling  human  metabolism  organoid  physiology  protein cerebrospinal fluid level  proteomics  single cell analysis  Blood-Brain Barrier  Cell Culture Techniques  Cerebrospinal Fluid  Cerebrospinal Fluid Proteins  Choroid Plexus  Gene Expression Profiling  Humans  Organoids  Proteomics  Single-Cell Analysis  
Widespread receptor-driven modulation in peripheral olfactory coding 期刊论文
, 2020, 卷号: 368, 期号: 6487
作者:  Xu L.;  Li W.;  Voleti V.;  Zou D.-J.;  Hillman E.M.C.;  Firestein S.
收藏  |  浏览/下载:25/0  |  提交时间:2020/07/28
antagonism  cell component  detection method  odor  olfaction  protein  animal cell  animal experiment  article  excitation  high throughput analysis  male  microscopy  mouse  nonhuman  odor  olfactory epithelium  olfactory receptor neuron  animal  confocal microscopy  innervation  mutant mouse strain  olfactory mucosa  physiology  single cell analysis  acetophenone  acetophenone derivative  benzyl acetate  benzyl derivative  citral  fragrance  Acetophenones  Acyclic Monoterpenes  Animals  Benzyl Compounds  Mice  Mice, Mutant Strains  Microscopy, Confocal  Odorants  Olfactory Mucosa  Olfactory Receptor Neurons  Single-Cell Analysis  Smell  
Metabolomics and mass spectrometry imaging reveal channeled de novo purine synthesis in cells 期刊论文
, 2020, 卷号: 368, 期号: 6488
作者:  Pareek V.;  Tian H.;  Winograd N.;  Benkovic S.J.
收藏  |  浏览/下载:30/0  |  提交时间:2020/07/28
adenosine phosphate  guanosine phosphate  multienzyme complex  nucleotide  purine  purine  purine derivative  cell  experimental study  imaging method  mass spectrometry  metabolism  protein  Article  biochemistry  enzyme assay  gas cluster ion beam secondary ion mass spectrometry  image analysis  mass spectrometry  metabolomics  mitochondrion  molecular imaging  molecular probe  priority journal  purine synthesis  reaction analysis  single cell analysis  biosynthesis  fluorescence imaging  HeLa cell line  human  metabolism  metabolomics  procedures  secondary ion mass spectrometry  HeLa Cells  Humans  Metabolomics  Mitochondria  Multienzyme Complexes  Optical Imaging  Purines  Single-Cell Analysis  Spectrometry, Mass, Secondary Ion  
Single-cell transcriptional diversity is a hallmark of developmental potential 期刊论文
, 2020, 卷号: 367, 期号: 6476
作者:  Gulati G.S.;  Sikandar S.S.;  Wesche D.J.;  Manjunath A.;  Bharadwaj A.;  Berger M.J.;  Ilagan F.;  Kuo A.H.;  Hsieh R.W.;  Cai S.;  Zabala M.;  Scheeren F.A.;  Lobo N.A.;  Qian D.;  Yu F.B.;  Dirbas F.M.;  Clarke M.F.;  Newman A.M.
收藏  |  浏览/下载:36/0  |  提交时间:2020/07/28
cell  cell component  developmental biology  experimental study  genetic analysis  tumor  Article  breast cancer  breast carcinogenesis  carcinogenesis  cell differentiation  computer model  embryonic stem cell  gene expression  genetic code  genetic variability  human  in vivo study  nonhuman  phenotype  priority journal  scoring system  single cell RNA seq  upregulation  
Very fast CRISPR on demand 期刊论文
, 2020, 卷号: 368, 期号: 6496
作者:  Liu Y.;  Zou R.S.;  He S.;  Nihongaki Y.;  Li X.;  Razavi S.;  Wu B.;  Ha T.
收藏  |  浏览/下载:20/0  |  提交时间:2020/07/28
Cas9 endonuclease Streptococcus pyogenes  double strand break repair protein MRE11  H2AX protein, human  histone  MRE11 protein, human  CRISPR Cas system  DNA cleavage  DNA repair  double stranded DNA break  fluorescence imaging  gene editing  genetics  HEK293 cell line  human  light  metabolism  phosphorylation  procedures  radiation response  single cell analysis  CRISPR-Associated Protein 9  CRISPR-Cas Systems  DNA Breaks, Double-Stranded  DNA Cleavage  DNA Repair  Gene Editing  HEK293 Cells  Histones  Humans  Light  MRE11 Homologue Protein  Optical Imaging  Phosphorylation  Single-Cell Analysis  
The evolutionary dynamics and fitness landscape of clonal hematopoiesis 期刊论文
, 2020, 卷号: 367, 期号: 6485
作者:  Watson C.J.;  Papula A.L.;  Poon G.Y.P.;  Wong W.H.;  Young A.L.;  Druley T.E.;  Fisher D.S.;  Blundell J.R.
收藏  |  浏览/下载:21/0  |  提交时间:2020/07/28
DNA methyltransferase 3A  blood  cancer  evolutionary biology  fitness  gene expression  genetic drift  hematology  mutation  pathogenicity  acute myeloid leukemia  age distribution  allele  Article  cancer risk  cell expansion  cell population  clonal hematopoiesis  epigenetics  gene mutation  genetic variability  hematological parameters  hematopoiesis  hematopoietic stem cell  human  molecular evolution  mutational analysis  nonhuman  priority journal  single nucleotide polymorphism  somatic mutation  stem cell self-renewal  
Massively multiplex chemical transcriptomics at single-cell resolution 期刊论文
, 2020, 卷号: 367, 期号: 6473
作者:  Srivatsan S.R.;  McFaline-Figueroa J.L.;  Ramani V.;  Saunders L.;  Cao J.;  Packer J.;  Pliner H.A.;  Jackson D.L.;  Daza R.M.;  Christiansen L.;  Zhang F.;  Steemers F.;  Shendure J.;  Trapnell C.
收藏  |  浏览/下载:13/0  |  提交时间:2020/07/28
4 (2 aminoethylamino) 1,8 dimethylimidazo[1,2 a]quinoxaline  abexinostat  acetic acid  belinostat  cudc 101  fimepinostat  givinostat  histone deacetylase inhibitor  m 344  n [2 [3 (1 piperazinylmethyl)imidazo[2,1 b]thiazol 6 yl]phenyl] 2 quinoxalinecarboxamide  panobinostat  pracinostat  rec 2282  trametinib  transcriptome  trichostatin A  unclassified drug  transcriptome  cancer  cell  chemical analysis  detection method  experimental study  genetic analysis  resolution  A-549 cell line  animal cell  animal experiment  Article  cell function  cell heterogeneity  cell labeling  cell proliferation  chromatin  controlled study  dose response  drug activity  experimentation  gene control  genetic transcription  human  human cell  K-562 cell line  MCF-7 cell line  mouse  nonhuman  pilot study  priority journal  proof of concept  RNA sequence  screening  single cell analysis  transcriptomics  cell nucleus  drug effect  genetics  genomics  high throughput screening  metabolism  neoplasm  procedures  single cell analysis  A549 Cells  Acetates  Cell Nucleus  Chromatin  Genomics  High-Throughput Screening Assays  Histone Deacetylase Inhibitors  Humans  K562 Cells  MCF-7 Cells  Neoplasms  RNA-Seq  Single-Cell Analysis  Transcriptome  
Regenerative potential of prostate luminal cells revealed by single-cell analysis 期刊论文
, 2020, 卷号: 368, 期号: 6490
作者:  Karthaus W.R.;  Hofree M.;  Choi D.;  Linton E.L.;  Turkekul M.;  Bejnood A.;  Carver B.;  Gopalan A.;  Abida W.;  Laudone V.;  Biton M.;  Chaudhary O.;  Xu T.;  Masilionis I.;  Manova K.;  Mazutis L.;  Pe’er D.;  Regev A.;  Sawyers C.L.
收藏  |  浏览/下载:98/0  |  提交时间:2020/07/28
androgen  growth factor  Nrg2 growth factor  Rspo3 growth factor  unclassified drug  androgen binding protein  antiandrogen  ataxin 1  Atxn1 protein, mouse  glycosylphosphatidylinositol anchored protein  homeodomain protein  nerve growth factor  Nkx3-1 protein, mouse  Nrg2 protein, mouse  probasin  Psca protein, mouse  R-spondin3 protein, mouse  thrombospondin  transcription factor  tumor antigen  tumor protein  androgen  cancer  cell  gene expression  RNA  rodent  ablation therapy  animal cell  animal tissue  Article  cell differentiation  cell population  cell regeneration  cells by body anatomy  controlled study  gene  gene expression  human  luminal cell  male  mesenchyme cell  mouse  nonhuman  paracrine signaling  priority journal  prostate cell  prostate tissue  protein expression  Psca gene  RNA sequencing  Sca1 gene  single cell analysis  animal  genetics  mesenchymal stem cell  metabolism  organ size  organoid  physiology  prostate  prostate tumor  regeneration  sequence analysis  single cell analysis  Mus  Androgen Antagonists  Androgen-Binding Protein  Androgens  Animals  Antigens, Neoplasm  Ataxin-1  Cell Differentiation  Gene Expression  GPI-Linked Proteins  Homeodomain Proteins  Humans  Male  Mesenchymal Stem Cells  Mice  Neoplasm Proteins  Nerve Growth Factors  Organ Size  Organoids  Prostate  Prostatic Neoplasms  Regeneration  Sequence Analysis, RNA  Single-Cell Analysis  Thrombospondins  Transcription Factors  
Cell position fates and collective fountain flow in bacterial biofilms revealed by light-sheet microscopy 期刊论文
, 2020, 卷号: 369, 期号: 6499
作者:  Qin B.;  Fei C.;  Bridges A.A.;  Mashruwala A.A.;  Stone H.A.;  Wingreen N.S.;  Bassler B.L.
收藏  |  浏览/下载:18/0  |  提交时间:2020/07/28
bacterial protein  scleroprotein  biofilm  cytology  genetics  metabolism  microscopy  motion  mutation  physiology  procedures  single cell analysis  Vibrio cholerae  Bacterial Proteins  Biofilms  Extracellular Matrix Proteins  Microscopy  Motion  Mutation  Single-Cell Analysis  Vibrio cholerae  
Lineage tracing on transcriptional landscapes links state to fate during differentiation 期刊论文
, 2020, 卷号: 367, 期号: 6479
作者:  Weinreb C.;  Rodriguez-Fraticelli A.;  Camargo F.D.;  Klein A.M.
收藏  |  浏览/下载:21/0  |  提交时间:2020/07/28
biology  cell component  differentiation  DNA  RNA  transcriptome  algorithm  animal  cell lineage  cytology  DNA barcoding  gene expression  genetics  hematopoiesis  monocyte  mouse  procedures  single cell analysis  Algorithms  Animals  Cell Lineage  DNA Barcoding, Taxonomic  Gene Expression  Hematopoiesis  Mice  Monocytes  RNA-Seq  Single-Cell Analysis  Transcriptome