气候变化领域集成服务门户(CCPortal): Widespread receptor-driven modulation in peripheral olfactory coding

CCPortal

DOI	10.1126/science.aaz5390
	Widespread receptor-driven modulation in peripheral olfactory coding
	Xu L.; Li W.; Voleti V.; Zou D.-J.; Hillman E.M.C.; Firestein S.
发表日期	2020
ISSN	0036-8075
卷号	368 期号:6487
英文摘要	Olfactory responses to single odors have been well characterized but in reality we are continually presented with complex mixtures of odors. We performed high-throughput analysis of single-cell responses to odor blends using Swept Confocally Aligned Planar Excitation (SCAPE) microscopy of intact mouse olfactory epithelium, imaging ∼10,000 olfactory sensory neurons in parallel. In large numbers of responding cells, mixtures of odors did not elicit a simple sum of the responses to individual components of the blend. Instead, many neurons exhibited either antagonism or enhancement of their response in the presence of another odor. All eight odors tested acted as both agonists and antagonists at different receptors. We propose that this peripheral modulation of responses increases the capacity of the olfactory system to distinguish complex odor mixtures. © 2020 American Association for the Advancement of Science. All rights reserved.
关键词	antagonism cell component detection method odor olfaction protein animal cell animal experiment article excitation high throughput analysis male microscopy mouse nonhuman odor olfactory epithelium olfactory receptor neuron animal confocal microscopy innervation mutant mouse strain olfactory mucosa physiology single cell analysis acetophenone acetophenone derivative benzyl acetate benzyl derivative citral fragrance Acetophenones Acyclic Monoterpenes Animals Benzyl Compounds Mice Mice, Mutant Strains Microscopy, Confocal Odorants Olfactory Mucosa Olfactory Receptor Neurons Single-Cell Analysis Smell
语种	英语
来源机构	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/133575
推荐引用方式 GB/T 7714	Xu L.,Li W.,Voleti V.,et al. Widespread receptor-driven modulation in peripheral olfactory coding[J]. Science,2020,368(6487).
APA	Xu L.,Li W.,Voleti V.,Zou D.-J.,Hillman E.M.C.,&Firestein S..(2020).Widespread receptor-driven modulation in peripheral olfactory coding.,368(6487).
MLA	Xu L.,et al."Widespread receptor-driven modulation in peripheral olfactory coding".368.6487(2020).