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Horizontal gene transfer of Fhb7 from fungus underlies Fusarium head blight resistance in wheat 期刊论文
, 2020, 卷号: 368, 期号: 6493
作者:  Wang H.;  Sun S.;  Ge W.;  Zhao L.;  Hou B.;  Wang K.;  Lyu Z.;  Chen L.;  Xu S.;  Guo J.;  Li M.;  Su P.;  Li X.;  Wang G.;  Bo C.;  Fang X.;  Zhuang W.;  Cheng X.;  Wu J.;  Dong L.;  Chen W.;  Li W.;  Xiao G.;  Zhao J.;  Hao Y.;  Xu Y.;  Gao Y.;  Liu W.;  Liu Y.;  Yin H.;  Li J.;  Li X.;  Zhao Y.;  Wang X.;  Ni F.;  Ma X.;  Li A.;  Xu S.S.;  Bai G.;  Nevo E.;  Gao C.;  Ohm H.;  Kong L.
收藏  |  浏览/下载:47/0  |  提交时间:2020/07/28
fungus  gene transfer  genome  germplasm  toxin  wheat  Fungi  Fusarium  Lophopyrum elongatum  Triticum aestivum  glutathione transferase  disease resistance  Epichloe  Fusarium  genetics  horizontal gene transfer  microbiology  molecular cloning  pathogenicity  plant breeding  plant disease  Poaceae  wheat  Cloning, Molecular  Disease Resistance  Epichloe  Fusarium  Gene Transfer, Horizontal  Glutathione Transferase  Plant Breeding  Plant Diseases  Poaceae  Triticum  
Na+-gated water-conducting nanochannels for boosting CO2 conversion to liquid fuels 期刊论文
, 2020, 卷号: 367, 期号: 6478
作者:  Li H.;  Qiu C.;  Ren S.;  Dong Q.;  Zhang S.;  Zhou F.;  Liang X.;  Wang J.;  Li S.;  Yu M.
收藏  |  浏览/下载:28/0  |  提交时间:2020/07/28
aluminum  carbon dioxide  carbon monoxide  copper  fuel  hydrogen  methanol  nanochannel  sodium ion  water  zeolite  zinc  carbon dioxide  high temperature  hydraulic conductivity  membrane  nanocomposite  nanotechnology  separation  sodium  thermodynamics  adsorption  Article  Brunauer Emmett Teller  catalyst  chemical composition  controlled study  crystal  density functional theory  energy dispersive X ray spectroscopy  gas  hydrogenation  measurement  priority journal  scanning electron microscopy  surface area  water permeability  
Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease 期刊论文
, 2020, 卷号: 368, 期号: 6497
作者:  Dai W.;  Zhang B.;  Jiang X.-M.;  Su H.;  Li J.;  Zhao Y.;  Xie X.;  Jin Z.;  Peng J.;  Liu F.;  Li C.;  Li Y.;  Bai F.;  Wang H.;  Cheng X.;  Cen X.;  Hu S.;  Yang X.;  Wang J.;  Liu X.;  Xiao G.;  Jiang H.;  Rao Z.;  Zhang L.-K.;  Xu Y.;  Yang H.;  Liu H.
收藏  |  浏览/下载:36/0  |  提交时间:2020/07/28
aldehyde  antimicrobial activity  drug  enzyme activity  infectivity  inhibitor  reaction kinetics  viral disease  Coronavirus  SARS coronavirus  3C-like proteinase, Coronavirus  antivirus agent  cysteine proteinase  viral protein  animal  Betacoronavirus  chemical structure  chemistry  Chlorocebus aethiops  Coronavirus infection  dog  drug design  drug effect  enzyme active site  enzymology  female  human  male  mouse  pandemic  preclinical study  protein tertiary structure  Sprague Dawley rat  toxicity testing  Vero cell line  virus pneumonia  Animals  Antiviral Agents  Betacoronavirus  Catalytic Domain  Chlorocebus aethiops  Coronavirus Infections  Cysteine Endopeptidases  Dogs  Drug Design  Drug Evaluation, Preclinical  Female  Humans  Male  Mice  Molecular Structure  Pandemics  Pneumonia, Viral  Protein Structure, Tertiary  Rats, Sprague-Dawley  Toxicity Tests  Vero Cells  Viral Nonstructural Proteins  
Chloride-mediated selective electrosynthesis of ethylene and propylene oxides at high current density 期刊论文
, 2020, 卷号: 368, 期号: 6496
作者:  Leow W.R.;  Lum Y.;  Ozden A.;  Wang Y.;  Nam D.-H.;  Chen B.;  Wicks J.;  Zhuang T.-T.;  Li F.;  Sinton D.;  Sargent E.H.
收藏  |  浏览/下载:29/0  |  提交时间:2020/07/28
alternative energy  chloride  electrochemical method  electrochemistry  ethylene  manufacturing  oxidation  oxide  plastic  polymer  
Structure of the RNA-dependent RNA polymerase from COVID-19 virus 期刊论文
, 2020, 卷号: 368, 期号: 6492
作者:  Gao Y.;  Yan L.;  Huang Y.;  Liu F.;  Zhao Y.;  Cao L.;  Wang T.;  Sun Q.;  Ming Z.;  Zhang L.;  Ge J.;  Zheng L.;  Zhang Y.;  Wang H.;  Zhu Y.;  Zhu C.;  Hu T.;  Hua T.;  Zhang B.;  Yang X.;  Li J.;  Yang H.;  Liu Z.;  Xu W.;  Guddat L.W.;  Wang Q.;  Lou Z.;  Rao Z.
收藏  |  浏览/下载:35/0  |  提交时间:2020/07/28
comparative study  drug  electron microscopy  enzyme  enzyme activity  RNA  virus  Coronavirus  SARS coronavirus  adenosine phosphate  alanine  antivirus agent  NSP7 protein, SARS-CoV-2  NSP8 protein, SARS-CoV-2  remdesivir  RNA directed RNA polymerase  RNA-dependent RNA polymerase, coronavirus  viral protein  beta sheet  Betacoronavirus  chemistry  cryoelectron microscopy  drug design  enzyme active site  enzymology  metabolism  molecular model  protein domain  ultrastructure  Adenosine Monophosphate  Alanine  Antiviral Agents  Betacoronavirus  Catalytic Domain  Cryoelectron Microscopy  Drug Design  Models, Molecular  Protein Conformation, beta-Strand  Protein Domains  RNA Replicase  Viral Nonstructural Proteins  
De novo protein design enables the precise induction of RSV-neutralizing antibodies 期刊论文
, 2020, 卷号: 368, 期号: 6492
作者:  Sesterhenn F.;  Yang C.;  Bonet J.;  Cramer J.T.;  Wen X.;  Wang Y.;  Chiang C.-I.;  Abriata L.A.;  Kucharska I.;  Castoro G.;  Vollers S.S.;  Galloux M.;  Dheilly E.;  Rosset S.;  Corthésy P.;  Georgeon S.;  Villard M.;  Richard C.-A.;  Descamps D.;  Delgado T.;  Oricchio E.;  Rameix-Welti M.-A.;  Más V.;  Ervin S.;  Eléouët J.-F.;  Riffault S.;  Bates J.T.;  Julien J.-P.;  Li Y.;  Jardetzky T.;  Krey T.;  Correia B.E.
收藏  |  浏览/下载:37/0  |  提交时间:2020/07/28
algorithm  antibody  design  neutralization  protein  vaccine  Mus  Primates  Respiratory syncytial virus  Rice stripe virus  epitope  fusion protein  nanobody  neutralizing antibody  respiratory syncytial virus vaccine  biology  biosynthesis  chemistry  human  Human respiratory syncytial virus  immunology  procedures  protein conformation  protein engineering  protein motif  Amino Acid Motifs  Antibodies, Neutralizing  Computational Biology  Humans  Immunodominant Epitopes  Protein Conformation  Protein Engineering  Recombinant Fusion Proteins  Respiratory Syncytial Virus Vaccines  Respiratory Syncytial Virus, Human  Single-Domain Antibodies  
Forest microclimate dynamics drive plant responses to warming 期刊论文
, 2020, 卷号: 368, 期号: 6492
作者:  Zellweger F.;  de Frenne P.;  Lenoir J.;  Vangansbeke P.;  Verheyen K.;  Bernhardt-Römermann M.;  Baeten L.;  Hédl R.;  Berki I.;  Brunet J.;  van Calster H.;  Chudomelová M.;  Decocq G.;  Dirnböck T.;  Durak T.;  Heinken T.;  Jaroszewicz B.;  Kopecký M.;  Máliš F.;  Macek M.;  Malicki M.;  Naaf T.;  Nagel T.A.;  Ortmann-Ajkai A.;  Petřík P.;  Pielech R.;  Reczynska K.;  Schmidt W.;  Standovár T.;  Swierkosz K.;  Teleki B.;  Vild O.;  Wulf M.;  Coomes D.
收藏  |  浏览/下载:24/0  |  提交时间:2020/07/28
biodiversity  canopy architecture  climate change  community response  disequilibrium  land use change  microclimate  plant community  understory  warming  Europe  forest  greenhouse effect  microclimate  physiology  tree  Europe  Forests  Global Warming  Microclimate  Trees  
A precise polyrotaxane synthesizer 期刊论文
, 2020, 卷号: 368, 期号: 6496
作者:  Qiu Y.;  Song B.;  Pezzato C.;  Shen D.;  Liu W.;  Zhang L.;  Feng Y.;  Guo Q.-H.;  Cai K.;  Li W.;  Chen H.;  Nguyen M.T.;  Shi Y.;  Cheng C.;  Dean Astumian R.;  Li X.;  Fraser Stoddart J.
收藏  |  浏览/下载:41/0  |  提交时间:2020/07/28
Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells 期刊论文
, 2020, 卷号: 368, 期号: 6494
作者:  Zhou Z.;  He H.;  Wang K.;  Shi X.;  Wang Y.;  Su Y.;  Wang Y.;  Li D.;  Liu W.;  Zhang Y.;  Shen L.;  Han W.;  Shen L.;  Ding J.;  Shao F.
收藏  |  浏览/下载:26/0  |  提交时间:2020/07/28
cell  cell component  cytology  enzyme  enzyme activity  gene expression  immunity  tumor  Mus  gamma interferon  granzyme  GSDMB protein, human  GZMA protein, human  pore forming cytotoxic protein  tumor protein  animal  Bagg albino mouse  chemistry  cytotoxic T lymphocyte  enzymology  genetics  HEK293 cell line  human  immunology  metabolism  mouse  natural killer cell  neoplasm  pathology  protein degradation  protein domain  pyroptosis  transgenic mouse  Animals  Granzymes  HEK293 Cells  Humans  Interferon-gamma  Killer Cells, Natural  Mice  Mice, Inbred BALB C  Mice, Transgenic  Neoplasm Proteins  Neoplasms  Pore Forming Cytotoxic Proteins  Protein Domains  Proteolysis  Pyroptosis  T-Lymphocytes, Cytotoxic  
VISTA is a checkpoint regulator for naïve T cell quiescence and peripheral tolerance 期刊论文
, 2020, 卷号: 367, 期号: 6475
作者:  ElTanbouly M.A.;  Zhao Y.;  Nowak E.;  Li J.;  Schaafsma E.;  Le Mercier I.;  Ceeraz S.;  Lines J.L.;  Peng C.;  Carriere C.;  Huang X.;  Day M.;  Koehn B.;  Lee S.W.;  Morales M.S.;  Hogquist K.A.;  Jameson S.C.;  Mueller D.;  Rothstein J.;  Blazar B.R.;  Cheng C.;  Noelle R.J.
收藏  |  浏览/下载:40/0  |  提交时间:2020/07/28
cell protein  interferon  kruppel like factor 2  T lymphocyte receptor  unclassified drug  V type immunoglobulin domain containing suppressor of T cell activation protein  B7 antigen  Dies1 protein, mouse  lymphocyte antigen receptor  membrane protein  monoclonal antibody  VSIR protein, human  biological development  cell  gene expression  heterogeneity  homeostasis  immune response  immunity  tolerance  acute graft versus host disease  animal cell  animal experiment  animal model  Article  CD4+ T lymphocyte  cell death  cell expansion  cell fate  cell heterogeneity  cell loss  cell survival  controlled study  female  gene  gene deletion  homeostasis  immunological tolerance  in vivo study  long term survival  male  mouse  nonhuman  phenotype  priority journal  protein expression  protein function  rheumatoid arthritis  RNA sequencing  systemic lupus erythematosus  T lymphocyte  T lymphocyte activation  T lymphocyte subpopulation  TCR gene  upregulation  VISTA gene  animal  C57BL mouse  genetics  immunological tolerance  immunology  knockout mouse  lymphocyte activation  physiology  T lymphocyte  Mus  Animals  Antibodies, Monoclonal  B7 Antigens  Lymphocyte Activation  Membrane Proteins  Mice  Mice, Inbred C57BL  Mice, Knockout  Peripheral Tolerance  Receptors, Antigen, T-Cell  T-Lymphocytes