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Jiang H. [2]
Li J. [2]
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期刊论文 [13]
发表日期
2020 [13]
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英语 [13]
来源机构
Science [13]
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Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease
期刊论文
, 2020, 卷号: 368, 期号: 6497
作者:
Dai W.
;
Zhang B.
;
Jiang X.-M.
;
Su H.
;
Li J.
;
Zhao Y.
;
Xie X.
;
Jin Z.
;
Peng J.
;
Liu F.
;
Li C.
;
Li Y.
;
Bai F.
;
Wang H.
;
Cheng X.
;
Cen X.
;
Hu S.
;
Yang X.
;
Wang J.
;
Liu X.
;
Xiao G.
;
Jiang H.
;
Rao Z.
;
Zhang L.-K.
;
Xu Y.
;
Yang H.
;
Liu H.
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2020/07/28
aldehyde
antimicrobial activity
drug
enzyme activity
infectivity
inhibitor
reaction kinetics
viral disease
Coronavirus
SARS coronavirus
3C-like proteinase, Coronavirus
antivirus agent
cysteine proteinase
viral protein
animal
Betacoronavirus
chemical structure
chemistry
Chlorocebus aethiops
Coronavirus infection
dog
drug design
drug effect
enzyme active site
enzymology
female
human
male
mouse
pandemic
preclinical study
protein tertiary structure
Sprague Dawley rat
toxicity testing
Vero cell line
virus pneumonia
Animals
Antiviral Agents
Betacoronavirus
Catalytic Domain
Chlorocebus aethiops
Coronavirus Infections
Cysteine Endopeptidases
Dogs
Drug Design
Drug Evaluation, Preclinical
Female
Humans
Male
Mice
Molecular Structure
Pandemics
Pneumonia, Viral
Protein Structure, Tertiary
Rats, Sprague-Dawley
Toxicity Tests
Vero Cells
Viral Nonstructural Proteins
Structure of the RNA-dependent RNA polymerase from COVID-19 virus
期刊论文
, 2020, 卷号: 368, 期号: 6492
作者:
Gao Y.
;
Yan L.
;
Huang Y.
;
Liu F.
;
Zhao Y.
;
Cao L.
;
Wang T.
;
Sun Q.
;
Ming Z.
;
Zhang L.
;
Ge J.
;
Zheng L.
;
Zhang Y.
;
Wang H.
;
Zhu Y.
;
Zhu C.
;
Hu T.
;
Hua T.
;
Zhang B.
;
Yang X.
;
Li J.
;
Yang H.
;
Liu Z.
;
Xu W.
;
Guddat L.W.
;
Wang Q.
;
Lou Z.
;
Rao Z.
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2020/07/28
comparative study
drug
electron microscopy
enzyme
enzyme activity
RNA
virus
Coronavirus
SARS coronavirus
adenosine phosphate
alanine
antivirus agent
NSP7 protein, SARS-CoV-2
NSP8 protein, SARS-CoV-2
remdesivir
RNA directed RNA polymerase
RNA-dependent RNA polymerase, coronavirus
viral protein
beta sheet
Betacoronavirus
chemistry
cryoelectron microscopy
drug design
enzyme active site
enzymology
metabolism
molecular model
protein domain
ultrastructure
Adenosine Monophosphate
Alanine
Antiviral Agents
Betacoronavirus
Catalytic Domain
Cryoelectron Microscopy
Drug Design
Models, Molecular
Protein Conformation, beta-Strand
Protein Domains
RNA Replicase
Viral Nonstructural Proteins
Transcription polymerase-catalyzed emergence of novel RNA replicons
期刊论文
, 2020, 卷号: 368, 期号: 6487
作者:
Jain N.
;
Blauch L.R.
;
Szymanski M.R.
;
Das R.
;
Tang S.K.Y.
;
Yin Y.W.
;
Fire A.Z.
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2020/07/28
cell component
enzyme
enzyme activity
genetic analysis
RNA
article
bacteriophage
catalysis
DNA replication origin
heredity
in vitro study
nonhuman
plant seed
replicon
RNA replication
synthesis
transcription initiation
biocatalysis
biosynthesis
genetic transcription
metabolism
Animalia
Hepatitis delta virus
Viroids
bacteriophage T7 RNA polymerase
DNA directed RNA polymerase
RNA
viral protein
Biocatalysis
DNA-Directed RNA Polymerases
Replicon
RNA
Transcription, Genetic
Viral Proteins
A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV
期刊论文
, 2020, 卷号: 368, 期号: 6491
作者:
Yuan M.
;
Wu N.C.
;
Zhu X.
;
Lee C.-C.D.
;
So R.T.Y.
;
Lv H.
;
Mok C.K.P.
;
Wilson I.A.
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2020/07/28
angiotensin converting enzyme 2
epitope
neutralizing antibody
virus hemagglutinin
virus spike protein
angiotensin converting enzyme 2
coronavirus receptors
coronavirus spike glycoprotein
dipeptidyl carboxypeptidase
epitope
neutralizing antibody
spike glycoprotein, SARS-CoV
spike protein, SARS-CoV-2
virus antibody
virus antigen
virus receptor
antibody
antigen
chemical binding
crystal structure
protein
respiratory disease
viral disease
virus
amino terminal sequence
antibody isolation
antigen binding
antigenicity
Article
binding affinity
binding site
conservation biology
controlled study
coronavirus disease 2019
cross reaction
cryoelectron microscopy
crystal structure
enzyme linked immunosorbent assay
epidemic
glycosylation
human
hydrophobicity
immune response
in vitro study
in vivo study
light chain
nonhuman
priority journal
protein conformation
protein domain
protein interaction
protein localization
protein structure
protein targeting
receptor binding
SARS coronavirus
Severe acute respiratory syndrome coronavirus 2
amino acid sequence
antibody affinity
Betacoronavirus
binding site
chemistry
immunology
metabolism
molecular model
SARS coronavirus
X ray crystallography
Coronavirus
SARS coronavirus
Amino Acid Sequence
Antibodies, Neutralizing
Antibodies, Viral
Antibody Affinity
Antigens, Viral
Betacoronavirus
Binding Sites
Cross Reactions
Crystallography, X-Ray
Epitopes
Models, Molecular
Peptidyl-Dipeptidase A
Protein Conformation
Protein Domains
Protein Interaction Domains and Motifs
Receptors, Virus
SARS Virus
Spike Glycoprotein, Coronavirus
A noncompeting pair of human neutralizing antibodies block COVID-19 virus binding to its receptor ACE2
期刊论文
, 2020, 卷号: 368, 期号: 6496
作者:
Wu Y.
;
Wang F.
;
Shen C.
;
Peng W.
;
Li D.
;
Zhao C.
;
Li Z.
;
Li S.
;
Bi Y.
;
Yang Y.
;
Gong Y.
;
Xiao H.
;
Fan Z.
;
Tan S.
;
Wu G.
;
Tan W.
;
Lu X.
;
Fan C.
;
Wang Q.
;
Liu Y.
;
Zhang C.
;
Qi J.
;
Gao G.F.
;
Gao F.
;
Liu L.
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2020/07/28
Coronavirus
angiotensin converting enzyme 2
coronavirus spike glycoprotein
dipeptidyl carboxypeptidase
epitope
monoclonal antibody
neutralizing antibody
virus antibody
virus receptor
animal
chemistry
Coronavirus infection
disease model
human
immunology
isolation and purification
lung
mouse
pandemic
protein domain
serodiagnosis
virology
virus load
virus pneumonia
Animals
Antibodies, Monoclonal
Antibodies, Neutralizing
Antibodies, Viral
Coronavirus Infections
Disease Models, Animal
Humans
Immunodominant Epitopes
Lung
Mice
Neutralization Tests
Pandemics
Peptidyl-Dipeptidase A
Pneumonia, Viral
Protein Domains
Receptors, Virus
Spike Glycoprotein, Coronavirus
Viral Load
Pulmonary surfactant-biomimetic nanoparticles potentiate heterosubtypic influenza immunity
期刊论文
, 2020, 卷号: 367, 期号: 6480
作者:
Wang J.
;
Li P.
;
Yu Y.
;
Fu Y.
;
Jiang H.
;
Lu M.
;
Sun Z.
;
Jiang S.
;
Lu L.
;
Wu M.X.
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2020/07/28
2',3' cyclic guanosine monophosphate adenosine monophosphate
influenza vaccine
interferon
nanoparticle
pulmonary surfactant biomimetic nanoparticle
purine nucleotide
surfactant protein A
surfactant protein D
unclassified drug
cell
drug resistance
immune response
immunity
induced response
influenza
nanoparticle
rodent
surfactant
vaccine
animal cell
animal experiment
animal model
animal tissue
Article
CD8+ T lymphocyte
cellular immunity
controlled study
cross protection
cytokine response
drug efficacy
drug safety
drug synthesis
female
human
humoral immunity
hydrophilicity
immune response
immunopathology
immunosurveillance
influenza
innate immunity
lung alveolus epithelium cell
lung alveolus macrophage
mouse
Mustela putorius furo
nanoencapsulation
nonhuman
priority journal
Mus
Mustela
Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved a-ketoamide inhibitors
期刊论文
, 2020, 卷号: 368, 期号: 6489
作者:
Zhang L.
;
Lin D.
;
Sun X.
;
Curth U.
;
Drosten C.
;
Sauerhering L.
;
Becker S.
;
Rox K.
;
Hilgenfeld R.
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2020/07/28
alanine
alpha ketoamide inhibitor
antivirus agent
isoleucine
leucine
proteinase
Severe acute respiratory syndrome coronavirus 2 main protease
threonine
unclassified drug
crystal structure
drug
enzyme
enzyme activity
inhibitor
reaction kinetics
amino acid sequence
animal cell
animal experiment
animal tissue
antiviral activity
Article
catalysis
catalytic efficiency
controlled study
crystal structure
dimerization
dissociation constant
drug clearance
drug design
drug distribution
drug half life
drug potency
drug protein binding
drug solubility
drug structure
EC50
enzyme inhibition
human
human cell
hydrogen bond
hydrophobicity
IC50
maximum concentration
mean residence time
metabolic stability
mouse
nonhuman
priority journal
protein structure
RNA replication
SARS coronavirus
Severe acute respiratory syndrome coronavirus 2
viral tropism
virus inhibition
Coronavirus
SARS coronavirus
Structural basis for strand-transfer inhibitor binding to HIV intasomes
期刊论文
, 2020, 卷号: 367, 期号: 6479
作者:
Passos D.O.
;
Li M.
;
Jóźwik I.K.
;
Zhao X.Z.
;
Santos-Martins D.
;
Yang R.
;
Smith S.J.
;
Jeon Y.
;
Forli S.
;
Hughes S.H.
;
Burke T.R.
;
Jr.
;
Craigie R.
;
Lyumkis D.
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2020/07/28
bictegravir
nucleoprotein
protein intasome
unclassified drug
viral protein
bictegravir
fused heterocyclic rings
integrase
integrase inhibitor
multiprotein complex
naphthyridine derivative
nucleoprotein
biochemistry
chemical binding
human immunodeficiency virus
inhibitor
protein
ultrastructure
amino terminal sequence
Article
carboxy terminal sequence
catalysis
cryoelectron microscopy
drug design
drug efficacy
drug protein binding
drug resistance
drug structure
enzyme active site
human
Human immunodeficiency virus infection
nonhuman
priority journal
protein purification
protein structure
antiviral resistance
chemistry
drug effect
genetics
Human immunodeficiency virus
virus DNA cell DNA interaction
Cryoelectron Microscopy
Drug Design
Drug Resistance, Viral
Heterocyclic Compounds, 4 or More Rings
HIV
HIV Integrase
HIV Integrase Inhibitors
Humans
Multiprotein Complexes
Naphthyridines
Nucleoproteins
Virus Integration
Structural basis for transcriptional start site control of HIV-1 RNA fate
期刊论文
, 2020, 卷号: 368, 期号: 6489
作者:
Brown J.D.
;
Kharytonchyk S.
;
Chaudry I.
;
Iyer A.S.
;
Carter H.
;
Becker G.
;
Desai Y.
;
Glang L.
;
Choi S.H.
;
Singh K.
;
Lopresti M.W.
;
Orellana M.
;
Rodriguez T.
;
Oboh U.
;
Hijji J.
;
Ghinger F.G.
;
Stewart K.
;
Francis D.
;
Edwards B.
;
Chen P.
;
Case D.A.
;
Telesnitsky A.
;
Summers M.F.
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2020/07/28
capped RNA
initiation factor 4E
messenger RNA
virus RNA
capped RNA
guanosine
initiation factor 4E
messenger RNA
virus RNA
cell
chemical binding
deuterium
genome
human immunodeficiency virus
physiological response
RNA
Article
base pairing
deuteron nuclear magnetic resonance
dimerization
DNA helix
energy transfer
gene control
gene function
gene number
human
Human immunodeficiency virus 1
nonhuman
priority journal
promoter region
RNA probe
RNA structure
RNA transcription
virus replication
5' untranslated region
base pairing
chemistry
DNA base composition
gene expression regulation
genetics
Human immunodeficiency virus 1
metabolism
nuclear magnetic resonance
protein synthesis
transcription initiation site
Eukaryota
Human immunodeficiency virus 1
5' Untranslated Regions
Base Composition
Base Pairing
Eukaryotic Initiation Factor-4E
Gene Expression Regulation, Viral
Guanosine
HIV-1
Humans
Nuclear Magnetic Resonance, Biomolecular
Protein Biosynthesis
RNA Caps
RNA, Messenger
RNA, Viral
Transcription Initiation Site
A rampage through the body
期刊论文
, 2020, 卷号: 368, 期号: 6489
作者:
Wadman M.
;
Couzin-Frankel J.
;
Kaiser J.
;
Matacic C.
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2020/07/28
blood
brain
brain drain
cell organelle
immune response
infectious disease
protein
viral disease
Article
clinical feature
coronavirus disease 2019
disease severity
disease transmission
human
mortality rate
patient care
patient risk
priority journal
risk factor
Betacoronavirus
blood vessel
brain
Coronavirus infection
female
lung
male
middle aged
multiple organ failure
pandemic
pathogenicity
pathology
virology
virus entry
virus pneumonia
Betacoronavirus
Blood Vessels
Brain
Coronavirus Infections
Female
Humans
Lung
Male
Middle Aged
Multiple Organ Failure
Pandemics
Pneumonia, Viral
Virus Internalization