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文献类型
期刊论文 [35]
发表日期
2020 [35]
语种
英语 [35]
来源机构
Science [35]
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CFLIPL protects macrophages from LPS-induced pyroptosis via inhibition of complex II formation
期刊论文
, 2020, 卷号: 367, 期号: 6484
作者:
Muendlein H.I.
;
Jetton D.
;
Connolly W.M.
;
Eidell K.P.
;
Magri Z.
;
Smirnova I.
;
Poltorak A.
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2020/07/28
FLICE inhibitory protein
interleukin 1beta
lipopolysaccharide
messenger RNA
succinate dehydrogenase (ubiquinone)
Casp1 protein, mouse
caspase 8
Cflar protein, mouse
cryopyrin
FLICE inhibitory protein
IL1B protein, mouse
inflammasome
interleukin 1beta
interleukin 1beta converting enzyme
lipopolysaccharide
succinate dehydrogenase (ubiquinone)
cell
enzyme activity
inhibition
maturation
protein
animal cell
animal experiment
Article
bone marrow derived macrophage
cell death
cell protection
complex formation
controlled study
cytokine release
in vitro study
inflammation
mouse
nonhuman
priority journal
protein analysis
protein degradation
protein function
protein interaction
pyroptosis
animal
gene knockdown
genetics
immunology
macrophage
macrophage activation
metabolism
physiology
Murinae
Animals
CASP8 and FADD-Like Apoptosis Regulating Protein
Caspase 1
Caspase 8
Electron Transport Complex II
Gene Knockdown Techniques
Inflammasomes
Interleukin-1beta
Lipopolysaccharides
Macrophage Activation
Macrophages
Mice
NLR Family, Pyrin Domain-Containing 3 Protein
Pyroptosis
Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations
期刊论文
, 2020, 卷号: 367, 期号: 6478
作者:
Wilmes S.
;
Hafer M.
;
Vuorio J.
;
Tucker J.A.
;
Winkelmann H.
;
Löchte S.
;
Stanly T.A.
;
Pulgar Prieto K.D.
;
Poojari C.
;
Sharma V.
;
Richter C.P.
;
Kurre R.
;
Hubbard S.R.
;
Christopher Garcia K.
;
Moraga I.
;
Vattulainen I.
;
Hitchcock I.S.
;
Piehler J.
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2020/07/28
cytokine receptor
homodimer
Janus kinase 2
ligand
oncoprotein
cancer
enzyme
enzyme activity
membrane
molecular analysis
mutation
protein
activation analysis
Article
cell membrane
computer model
controlled study
dimerization
fluorescence microscopy
gene mutation
HeLa cell line
molecular dynamics
mutant
oncogene
priority journal
protein domain
protein interaction
quantitative analysis
signal transduction
Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease
期刊论文
, 2020, 卷号: 368, 期号: 6497
作者:
Dai W.
;
Zhang B.
;
Jiang X.-M.
;
Su H.
;
Li J.
;
Zhao Y.
;
Xie X.
;
Jin Z.
;
Peng J.
;
Liu F.
;
Li C.
;
Li Y.
;
Bai F.
;
Wang H.
;
Cheng X.
;
Cen X.
;
Hu S.
;
Yang X.
;
Wang J.
;
Liu X.
;
Xiao G.
;
Jiang H.
;
Rao Z.
;
Zhang L.-K.
;
Xu Y.
;
Yang H.
;
Liu H.
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2020/07/28
aldehyde
antimicrobial activity
drug
enzyme activity
infectivity
inhibitor
reaction kinetics
viral disease
Coronavirus
SARS coronavirus
3C-like proteinase, Coronavirus
antivirus agent
cysteine proteinase
viral protein
animal
Betacoronavirus
chemical structure
chemistry
Chlorocebus aethiops
Coronavirus infection
dog
drug design
drug effect
enzyme active site
enzymology
female
human
male
mouse
pandemic
preclinical study
protein tertiary structure
Sprague Dawley rat
toxicity testing
Vero cell line
virus pneumonia
Animals
Antiviral Agents
Betacoronavirus
Catalytic Domain
Chlorocebus aethiops
Coronavirus Infections
Cysteine Endopeptidases
Dogs
Drug Design
Drug Evaluation, Preclinical
Female
Humans
Male
Mice
Molecular Structure
Pandemics
Pneumonia, Viral
Protein Structure, Tertiary
Rats, Sprague-Dawley
Toxicity Tests
Vero Cells
Viral Nonstructural Proteins
T cells with dysfunctional mitochondria induce multimorbidity and premature senescence
期刊论文
, 2020, 卷号: 368, 期号: 6497
作者:
Desdín-Micó G.
;
Soto-Heredero G.
;
Aranda J.F.
;
Oller J.
;
Carrasco E.
;
Gabandé-Rodríguez E.
;
Blanco E.M.
;
Alfranca A.
;
Cussó L.
;
Desco M.
;
Ibañez B.
;
Gortazar A.R.
;
Fernández-Marcos P.
;
Navarro M.N.
;
Hernaez B.
;
Alcamí A.
;
Baixauli F.
;
Mittelbrunn M.
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2020/07/28
cardiovascular disease
enzyme activity
gene expression
metabolism
mitochondrial DNA
morbidity
senescence
tumor
Mus
DNA binding protein
mitochondrial protein
mitochondrial transcription factor A
nicotinamide adenine dinucleotide
transcription factor
tumor necrosis factor
animal
cytokine release syndrome
female
fitness
gene deletion
genetics
immunology
inflammation
longevity
male
metabolism
mitochondrion
mouse
multiple chronic conditions
mutant mouse strain
premature aging
T lymphocyte
ultrastructure
Aging, Premature
Animals
Cytokine Release Syndrome
DNA-Binding Proteins
Female
Gene Deletion
Inflammation
Longevity
Male
Mice
Mice, Mutant Strains
Mitochondria
Mitochondrial Proteins
Multimorbidity
NAD
Physical Fitness
T-Lymphocytes
Transcription Factors
Tumor Necrosis Factor-alpha
Computing cancer's weak spots
期刊论文
, 2020, 卷号: 368, 期号: 6496
作者:
Khamsi R.
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2020/07/28
ruxolitinib
STAT3 protein
antineoplastic agent
transcription factor
algorithm
cancer
computer simulation
disease treatment
drug development
medicine
Article
cancer cell
cancer radiotherapy
enzyme inhibition
gene activity
gene expression regulation
gene interaction
gene mutation
gene repression
gene targeting
human
laboratory test
malignant neoplasm
molecular dynamics
nonhuman
oncologist
priority journal
RNA sequencing
algorithm
genetics
mutation
neoplasm
personalized medicine
procedures
systems biology
Algorithms
Antineoplastic Agents
Humans
Mutation
Neoplasms
Precision Medicine
Systems Biology
Transcription Factors
Structure of the RNA-dependent RNA polymerase from COVID-19 virus
期刊论文
, 2020, 卷号: 368, 期号: 6492
作者:
Gao Y.
;
Yan L.
;
Huang Y.
;
Liu F.
;
Zhao Y.
;
Cao L.
;
Wang T.
;
Sun Q.
;
Ming Z.
;
Zhang L.
;
Ge J.
;
Zheng L.
;
Zhang Y.
;
Wang H.
;
Zhu Y.
;
Zhu C.
;
Hu T.
;
Hua T.
;
Zhang B.
;
Yang X.
;
Li J.
;
Yang H.
;
Liu Z.
;
Xu W.
;
Guddat L.W.
;
Wang Q.
;
Lou Z.
;
Rao Z.
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2020/07/28
comparative study
drug
electron microscopy
enzyme
enzyme activity
RNA
virus
Coronavirus
SARS coronavirus
adenosine phosphate
alanine
antivirus agent
NSP7 protein, SARS-CoV-2
NSP8 protein, SARS-CoV-2
remdesivir
RNA directed RNA polymerase
RNA-dependent RNA polymerase, coronavirus
viral protein
beta sheet
Betacoronavirus
chemistry
cryoelectron microscopy
drug design
enzyme active site
enzymology
metabolism
molecular model
protein domain
ultrastructure
Adenosine Monophosphate
Alanine
Antiviral Agents
Betacoronavirus
Catalytic Domain
Cryoelectron Microscopy
Drug Design
Models, Molecular
Protein Conformation, beta-Strand
Protein Domains
RNA Replicase
Viral Nonstructural Proteins
Elesclomol alleviates Menkes pathology and mortality by escorting Cu to cuproenzymes in mice
期刊论文
, 2020, 卷号: 368, 期号: 6491
作者:
Guthrie L.M.
;
Soma S.
;
Yuan S.
;
Silva A.
;
Zulkifli M.
;
Snavely T.C.
;
Greene H.F.
;
Nunez E.
;
Lynch B.
;
de Ville C.
;
Shanbhag V.
;
Lopez F.R.
;
Acharya A.
;
Petris M.J.
;
Kim B.-E.
;
Gohil V.M.
;
Sacchettini J.C.
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2020/07/28
copper
copper zinc superoxide dismutase
cytochrome c oxidase
dopamine beta monooxygenase
elesclomol
monophenol monooxygenase
protein lysine 6 oxidase
copper
cytochrome c oxidase
elesclomol
hydrazine derivative
copper
cytochrome
enzyme
enzyme activity
mitochondrion
mortality
mutation
pathology
rodent
survival
animal cell
animal experiment
animal model
animal tissue
Article
cohort analysis
controlled study
disease severity
drug mechanism
Golgi complex
H9c2(2-1) cell line
in vivo study
male
Menkes syndrome
mitochondrial dynamics
mortality rate
mouse
nerve degeneration
nonhuman
priority journal
secretory pathway
survival rate
animal
brain
cell line
degenerative disease
disease model
drug effect
genetics
knockout mouse
Menkes syndrome
metabolism
mitochondrion
pathology
rat
transport at the cellular level
Murinae
Mus
Animals
Biological Transport
Brain
Cell Line
Copper
Copper Transporter 1
Disease Models, Animal
Electron Transport Complex IV
Hydrazines
Male
Menkes Kinky Hair Syndrome
Mice
Mice, Knockout
Mitochondria
Neurodegenerative Diseases
Rats
Transcription polymerase-catalyzed emergence of novel RNA replicons
期刊论文
, 2020, 卷号: 368, 期号: 6487
作者:
Jain N.
;
Blauch L.R.
;
Szymanski M.R.
;
Das R.
;
Tang S.K.Y.
;
Yin Y.W.
;
Fire A.Z.
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2020/07/28
cell component
enzyme
enzyme activity
genetic analysis
RNA
article
bacteriophage
catalysis
DNA replication origin
heredity
in vitro study
nonhuman
plant seed
replicon
RNA replication
synthesis
transcription initiation
biocatalysis
biosynthesis
genetic transcription
metabolism
Animalia
Hepatitis delta virus
Viroids
bacteriophage T7 RNA polymerase
DNA directed RNA polymerase
RNA
viral protein
Biocatalysis
DNA-Directed RNA Polymerases
Replicon
RNA
Transcription, Genetic
Viral Proteins
Microenvironment mapping via Dexter energy transfer on immune cells
期刊论文
, 2020, 卷号: 367, 期号: 6482
作者:
Geri J.B.
;
Oakley J.V.
;
Reyes-Robles T.
;
Wang T.
;
McCarver S.J.
;
White C.H.
;
Rodriguez-Rivera F.P.
;
Parker D.L.
;
Hett E.C.
;
Fadeyi O.O.
;
Oslund R.C.
;
MacMillan D.W.C.
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2020/07/28
antibody conjugate
carbene
programmed death 1 ligand 1
methane
programmed death 1 ligand 1
antibody
catalysis
catalyst
cell component
detection method
enzyme
enzyme activity
protein
antigen binding
Article
cell membrane
energy transfer
human
immunocompetent cell
immunological synapse
lymphocyte
photocatalysis
priority journal
protein analysis
protein protein interaction
tumor microenvironment
catalysis
chemistry
energy transfer
Jurkat cell line
metabolism
photochemistry
procedures
radiation response
ultraviolet radiation
B7-H1 Antigen
Catalysis
Cell Membrane
Cellular Microenvironment
Energy Transfer
Humans
Jurkat Cells
Lymphocytes
Methane
Photochemical Processes
Protein Interaction Mapping
Protein Interaction Maps
Ultraviolet Rays
Unconstrained genome targeting with near-PAMless engineered CRISPR-Cas9 variants
期刊论文
, 2020, 卷号: 368, 期号: 6488
作者:
Walton R.T.
;
Christie K.A.
;
Whittaker M.N.
;
Kleinstiver B.P.
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2020/07/28
adenine
adenosine
CRISPR associated endonuclease Cas9
cytosine
guanosine
SpG protein
SpRY nuclease
thymine
unclassified drug
Cas9 endonuclease Streptococcus pyogenes
bacterium
enzyme activity
genetic engineering
genetic variation
genome
Article
CRISPR-CAS9 system
DNA sequence
enzyme activity
gene editing
gene targeting
genetic variability
human
mutagenesis
nonhuman
priority journal
protein engineering
protein motif
protein structure
protospacer adjacent motif
Streptococcus pyogenes
chemistry
CRISPR Cas system
enzyme specificity
gene editing
gene targeting
genetic predisposition
genetics
HEK293 cell line
procedures
protein domain
Streptococcus pyogenes
CRISPR-Associated Protein 9
CRISPR-Cas Systems
Gene Editing
Gene Targeting
Genetic Predisposition to Disease
HEK293 Cells
Humans
Mutagenesis
Protein Domains
Substrate Specificity