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Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease 期刊论文
, 2020, 卷号: 368, 期号: 6497
作者:  Dai W.;  Zhang B.;  Jiang X.-M.;  Su H.;  Li J.;  Zhao Y.;  Xie X.;  Jin Z.;  Peng J.;  Liu F.;  Li C.;  Li Y.;  Bai F.;  Wang H.;  Cheng X.;  Cen X.;  Hu S.;  Yang X.;  Wang J.;  Liu X.;  Xiao G.;  Jiang H.;  Rao Z.;  Zhang L.-K.;  Xu Y.;  Yang H.;  Liu H.
收藏  |  浏览/下载：36/0  |  提交时间：2020/07/28
aldehyde  antimicrobial activity  drug  enzyme activity  infectivity  inhibitor  reaction kinetics  viral disease  Coronavirus  SARS coronavirus  3C-like proteinase, Coronavirus  antivirus agent  cysteine proteinase  viral protein  animal  Betacoronavirus  chemical structure  chemistry  Chlorocebus aethiops  Coronavirus infection  dog  drug design  drug effect  enzyme active site  enzymology  female  human  male  mouse  pandemic  preclinical study  protein tertiary structure  Sprague Dawley rat  toxicity testing  Vero cell line  virus pneumonia  Animals  Antiviral Agents  Betacoronavirus  Catalytic Domain  Chlorocebus aethiops  Coronavirus Infections  Cysteine Endopeptidases  Dogs  Drug Design  Drug Evaluation, Preclinical  Female  Humans  Male  Mice  Molecular Structure  Pandemics  Pneumonia, Viral  Protein Structure, Tertiary  Rats, Sprague-Dawley  Toxicity Tests  Vero Cells  Viral Nonstructural Proteins  
Structure of the RNA-dependent RNA polymerase from COVID-19 virus 期刊论文
, 2020, 卷号: 368, 期号: 6492
作者:  Gao Y.;  Yan L.;  Huang Y.;  Liu F.;  Zhao Y.;  Cao L.;  Wang T.;  Sun Q.;  Ming Z.;  Zhang L.;  Ge J.;  Zheng L.;  Zhang Y.;  Wang H.;  Zhu Y.;  Zhu C.;  Hu T.;  Hua T.;  Zhang B.;  Yang X.;  Li J.;  Yang H.;  Liu Z.;  Xu W.;  Guddat L.W.;  Wang Q.;  Lou Z.;  Rao Z.
收藏  |  浏览/下载：38/0  |  提交时间：2020/07/28
comparative study  drug  electron microscopy  enzyme  enzyme activity  RNA  virus  Coronavirus  SARS coronavirus  adenosine phosphate  alanine  antivirus agent  NSP7 protein, SARS-CoV-2  NSP8 protein, SARS-CoV-2  remdesivir  RNA directed RNA polymerase  RNA-dependent RNA polymerase, coronavirus  viral protein  beta sheet  Betacoronavirus  chemistry  cryoelectron microscopy  drug design  enzyme active site  enzymology  metabolism  molecular model  protein domain  ultrastructure  Adenosine Monophosphate  Alanine  Antiviral Agents  Betacoronavirus  Catalytic Domain  Cryoelectron Microscopy  Drug Design  Models, Molecular  Protein Conformation, beta-Strand  Protein Domains  RNA Replicase  Viral Nonstructural Proteins  
A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV 期刊论文
, 2020, 卷号: 368, 期号: 6491
作者:  Yuan M.;  Wu N.C.;  Zhu X.;  Lee C.-C.D.;  So R.T.Y.;  Lv H.;  Mok C.K.P.;  Wilson I.A.
收藏  |  浏览/下载：17/0  |  提交时间：2020/07/28
angiotensin converting enzyme 2  epitope  neutralizing antibody  virus hemagglutinin  virus spike protein  angiotensin converting enzyme 2  coronavirus receptors  coronavirus spike glycoprotein  dipeptidyl carboxypeptidase  epitope  neutralizing antibody  spike glycoprotein, SARS-CoV  spike protein, SARS-CoV-2  virus antibody  virus antigen  virus receptor  antibody  antigen  chemical binding  crystal structure  protein  respiratory disease  viral disease  virus  amino terminal sequence  antibody isolation  antigen binding  antigenicity  Article  binding affinity  binding site  conservation biology  controlled study  coronavirus disease 2019  cross reaction  cryoelectron microscopy  crystal structure  enzyme linked immunosorbent assay  epidemic  glycosylation  human  hydrophobicity  immune response  in vitro study  in vivo study  light chain  nonhuman  priority journal  protein conformation  protein domain  protein interaction  protein localization  protein structure  protein targeting  receptor binding  SARS coronavirus  Severe acute respiratory syndrome coronavirus 2  amino acid sequence  antibody affinity  Betacoronavirus  binding site  chemistry  immunology  metabolism  molecular model  SARS coronavirus  X ray crystallography  Coronavirus  SARS coronavirus  Amino Acid Sequence  Antibodies, Neutralizing  Antibodies, Viral  Antibody Affinity  Antigens, Viral  Betacoronavirus  Binding Sites  Cross Reactions  Crystallography, X-Ray  Epitopes  Models, Molecular  Peptidyl-Dipeptidase A  Protein Conformation  Protein Domains  Protein Interaction Domains and Motifs  Receptors, Virus  SARS Virus  Spike Glycoprotein, Coronavirus  
Quantifying SARS-CoV-2 transmission suggests epidemic control with digital contact tracing 期刊论文
, 2020, 卷号: 368, 期号: 6491
作者:  Ferretti L.;  Wymant C.;  Kendall M.;  Zhao L.;  Nurtay A.;  Abeler-Dörner L.;  Parker M.;  Bonsall D.;  Fraser C.
收藏  |  浏览/下载：23/0  |  提交时间：2020/07/28
disease control  epidemic  memory  parasite transmission  viral disease  Article  asymptomatic disease  China  contact examination  coronavirus disease 2019  disease control  disease transmission  health care system  human  incubation time  mathematical model  mobile application  mortality rate  priority journal  quarantine  rating scale  Severe acute respiratory syndrome coronavirus 2  virus transmission  algorithm  basic reproduction number  Betacoronavirus  contact examination  Coronavirus infection  epidemic  ethics  infection control  mobile application  mobile phone  pandemic  probability  procedures  theoretical model  time factor  virus pneumonia  Coronavirus  SARS coronavirus  Algorithms  Asymptomatic Diseases  Basic Reproduction Number  Betacoronavirus  Cell Phone  China  Contact Tracing  Coronavirus Infections  Epidemics  Humans  Infection Control  Mobile Applications  Models, Theoretical  Pandemics  Pneumonia, Viral  Probability  Quarantine  Time Factors  
Rapid implementation of mobile technology for real-time epidemiology of COVID-19 期刊论文
, 2020, 卷号: 368, 期号: 6497
作者:  Drew D.A.;  Nguyen L.H.;  Steves C.J.;  Menni C.;  Freydin M.;  Varsavsky T.;  Sudre C.H.;  Jorge Cardoso M.;  Ourselin S.;  Wolf J.;  Spector T.D.;  Chan A.T.;  COPE Consortium
收藏  |  浏览/下载：27/0  |  提交时间：2020/07/28
data assimilation  epidemiology  public health  real time  risk factor  severe acute respiratory syndrome  viral disease  United Kingdom  United States  Coronavirus  SARS coronavirus  Betacoronavirus  Coronavirus infection  devices  global health  human  information processing  international cooperation  mobile application  pandemic  procedures  theoretical model  United Kingdom  United States  virus pneumonia  Betacoronavirus  Big Data  Coronavirus Infections  Data Collection  Global Health  Humans  International Cooperation  Mobile Applications  Models, Theoretical  Pandemics  Pneumonia, Viral  United Kingdom  United States  
Comparative pathogenesis of COVID-19, MERS, and SARS in a nonhuman primate model 期刊论文
, 2020, 卷号: 368, 期号: 6494
作者:  Rockx B.;  Kuiken T.;  Herfst S.;  Bestebroer T.;  Lamers M.M.;  Munnink B.B.O.;  De Meulder D.;  Van Amerongen G.;  Van Den Brand J.;  Okba N.M.A.;  Schipper D.;  Van Run P.;  Leijten L.;  Sikkema R.;  Verschoor E.;  Verstrepen B.;  Bogers W.;  Langermans J.;  Langermans J.;  Drosten C.;  Van Vlissingen M.F.;  Fouchier R.;  De Swart R.;  Koopmans M.;  Haagmans B.L.
收藏  |  浏览/下载：21/0  |  提交时间：2020/07/28
pathogenicity  pathology  primate  severe acute respiratory syndrome  viral disease  virus  Middle East  Coronavirus  Macaca  Primates  SARS coronavirus  aging  animal  Betacoronavirus  comparative study  Coronavirus infection  disease model  female  isolation and purification  lung  lung alveolus  Macaca fascicularis  Middle East respiratory syndrome coronavirus  pandemic  pathogenicity  pathology  physiology  respiratory system  SARS coronavirus  severe acute respiratory syndrome  virology  virus pneumonia  virus replication  virus shedding  Aging  Animals  Betacoronavirus  Coronavirus Infections  Disease Models, Animal  Female  Lung  Macaca fascicularis  Middle East Respiratory Syndrome Coronavirus  Pandemics  Pneumonia, Viral  Pulmonary Alveoli  Respiratory System  SARS Virus  Severe Acute Respiratory Syndrome  Virus Replication  Virus Shedding  
Susceptibility of ferrets, cats, dogs, and other domesticated animals to SARS-coronavirus 2 期刊论文
, 2020, 卷号: 368, 期号: 6494
作者:  Shi J.;  Wen Z.;  Zhong G.;  Yang H.;  Wang C.;  Huang B.;  Liu R.;  He X.;  Shuai L.;  Sun Z.;  Zhao Y.;  Liu P.;  Liang L.;  Cui P.;  Wang J.;  Zhang X.;  Guan Y.;  Tan W.;  Wu G.;  Chen H.;  Bu Z.;  Bu Z.
收藏  |  浏览/下载：32/0  |  提交时间：2020/07/28
bat  canid  disease control  disease transmission  felid  global perspective  infectious disease  poultry  severe acute respiratory syndrome  viral disease  virus  China  Hubei  Wuhan  Anas  Animalia  Canis familiaris  Coronavirus  Gallus gallus  Mustela  SARS coronavirus  Suidae  virus antibody  virus RNA  animal  Betacoronavirus  blood  cat  chicken  Coronavirus infection  disease model  disease predisposition  dog  domestic animal  duck  feces  female  immunology  isolation and purification  male  Mustela putorius furo  pandemic  physiology  pig  respiratory system  species difference  virology  virus attachment  virus pneumonia  virus replication  Animals  Animals, Domestic  Antibodies, Viral  Betacoronavirus  Cats  Chickens  Coronavirus Infections  Disease Models, Animal  Disease Susceptibility  Dogs  Ducks  Feces  Female  Ferrets  Male  Pandemics  Pneumonia, Viral  Respiratory System  RNA, Viral  Species Specificity  Sus scrofa  Virus Attachment  Virus Replication  
Projecting the transmission dynamics of SARS-CoV-2 through the postpandemic period 期刊论文
, 2020, 卷号: 368, 期号: 6493
作者:  Kissler S.M.;  Tedijanto C.;  Goldstein E.;  Grad Y.H.;  Lipsitch M.
收藏  |  浏览/下载：12/0  |  提交时间：2020/07/28
data set  disease transmission  immunity  virus  United States  Coronavirus  SARS coronavirus  Betacoronavirus  biological model  Coronavirus infection  disease transmission  epidemic  human  Human coronavirus OC43  immunology  pandemic  physiology  season  virology  virus pneumonia  Betacoronavirus  Coronavirus Infections  Coronavirus OC43, Human  Disease Outbreaks  Disease Transmission, Infectious  Humans  Models, Biological  Pandemics  Pneumonia, Viral  Seasons  
Substantial undocumented infection facilitates the rapid dissemination of novel coronavirus (SARS-CoV-2) 期刊论文
, 2020, 卷号: 368, 期号: 6490
作者:  Li R.;  Pei S.;  Chen B.;  Song Y.;  Zhang T.;  Yang W.;  Shaman J.
收藏  |  浏览/下载：26/0  |  提交时间：2020/07/28
disease prevalence  disease spread  disease transmission  infectious disease  metapopulation  population modeling  viral disease  virus  Article  Bayes theorem  China  conceptual framework  coronavirus disease 2019  data analysis  disease severity  disease transmission  documentation  human  mathematical model  metapopulation  nonhuman  priority journal  Severe acute respiratory syndrome coronavirus 2  travel  validation process  China  Coronavirus  SARS coronavirus  
Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved a-ketoamide inhibitors 期刊论文
, 2020, 卷号: 368, 期号: 6489
作者:  Zhang L.;  Lin D.;  Sun X.;  Curth U.;  Drosten C.;  Sauerhering L.;  Becker S.;  Rox K.;  Hilgenfeld R.
收藏  |  浏览/下载：29/0  |  提交时间：2020/07/28
alanine  alpha ketoamide inhibitor  antivirus agent  isoleucine  leucine  proteinase  Severe acute respiratory syndrome coronavirus 2 main protease  threonine  unclassified drug  crystal structure  drug  enzyme  enzyme activity  inhibitor  reaction kinetics  amino acid sequence  animal cell  animal experiment  animal tissue  antiviral activity  Article  catalysis  catalytic efficiency  controlled study  crystal structure  dimerization  dissociation constant  drug clearance  drug design  drug distribution  drug half life  drug potency  drug protein binding  drug solubility  drug structure  EC50  enzyme inhibition  human  human cell  hydrogen bond  hydrophobicity  IC50  maximum concentration  mean residence time  metabolic stability  mouse  nonhuman  priority journal  protein structure  RNA replication  SARS coronavirus  Severe acute respiratory syndrome coronavirus 2  viral tropism  virus inhibition  Coronavirus  SARS coronavirus