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| DOI | 10.1126/science.abb7314 |
| Comparative pathogenesis of COVID-19, MERS, and SARS in a nonhuman primate model | |
| Rockx B.; Kuiken T.; Herfst S.; Bestebroer T.; Lamers M.M.; Munnink B.B.O.; De Meulder D.; Van Amerongen G.; Van Den Brand J.; Okba N.M.A.; Schipper D.; Van Run P.; Leijten L.; Sikkema R.; Verschoor E.; Verstrepen B.; Bogers W.; Langermans J.; Langermans J.; Drosten C.; Van Vlissingen M.F.; Fouchier R.; De Swart R.; Koopmans M.; Haagmans B.L. | |
| 发表日期 | 2020 |
| ISSN | 0036-8075 |
| 起始页码 | 1012 |
| 结束页码 | 1015 |
| 卷号 | 368期号:6494 |
| 英文摘要 | The current pandemic coronavirus, severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2), was recently identified in patients with an acute respiratory syndrome, coronavirus disease 2019 (COVID-19). To compare its pathogenesis with that of previously emerging coronaviruses, we inoculated cynomolgus macaques with SARS-CoV-2 or Middle East respiratory syndrome (MERS)-CoV and compared the pathology and virology with historical reports of SARS-CoV infections. In SARS-CoV-2-infected macaques, virus was excreted from nose and throat in the absence of clinical signs and detected in type I and II pneumocytes in foci of diffuse alveolar damage and in ciliated epithelial cells of nasal, bronchial, and bronchiolar mucosae. In SARS-CoV infection, lung lesions were typically more severe, whereas they were milder in MERS-CoV infection, where virus was detected mainly in type II pneumocytes. These data show that SARS-CoV-2 causes COVID-19-like disease in macaques and provides a new model to test preventive and therapeutic strategies. © 2020 American Association for the Advancement of Science. All rights reserved. |
| 关键词 | pathogenicitypathologyprimatesevere acute respiratory syndromeviral diseasevirusMiddle EastCoronavirusMacacaPrimatesSARS coronavirusaginganimalBetacoronaviruscomparative studyCoronavirus infectiondisease modelfemaleisolation and purificationlunglung alveolusMacaca fascicularisMiddle East respiratory syndrome coronaviruspandemicpathogenicitypathologyphysiologyrespiratory systemSARS coronavirussevere acute respiratory syndromevirologyvirus pneumoniavirus replicationvirus sheddingAgingAnimalsBetacoronavirusCoronavirus InfectionsDisease Models, AnimalFemaleLungMacaca fascicularisMiddle East Respiratory Syndrome CoronavirusPandemicsPneumonia, ViralPulmonary AlveoliRespiratory SystemSARS VirusSevere Acute Respiratory SyndromeVirus ReplicationVirus Shedding |
| 语种 | 英语 |
| 来源机构 | Science |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/133473 |
| 推荐引用方式 GB/T 7714 | Rockx B.,Kuiken T.,Herfst S.,et al. Comparative pathogenesis of COVID-19, MERS, and SARS in a nonhuman primate model[J]. Science,2020,368(6494). |
| APA | Rockx B..,Kuiken T..,Herfst S..,Bestebroer T..,Lamers M.M..,...&Haagmans B.L..(2020).Comparative pathogenesis of COVID-19, MERS, and SARS in a nonhuman primate model.,368(6494). |
| MLA | Rockx B.,et al."Comparative pathogenesis of COVID-19, MERS, and SARS in a nonhuman primate model".368.6494(2020). |
| 条目包含的文件 | 条目无相关文件。 | |||||
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