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CFLIPL protects macrophages from LPS-induced pyroptosis via inhibition of complex II formation 期刊论文
, 2020, 卷号: 367, 期号: 6484
作者:  Muendlein H.I.;  Jetton D.;  Connolly W.M.;  Eidell K.P.;  Magri Z.;  Smirnova I.;  Poltorak A.
收藏  |  浏览/下载：41/0  |  提交时间：2020/07/28
FLICE inhibitory protein  interleukin 1beta  lipopolysaccharide  messenger RNA  succinate dehydrogenase (ubiquinone)  Casp1 protein, mouse  caspase 8  Cflar protein, mouse  cryopyrin  FLICE inhibitory protein  IL1B protein, mouse  inflammasome  interleukin 1beta  interleukin 1beta converting enzyme  lipopolysaccharide  succinate dehydrogenase (ubiquinone)  cell  enzyme activity  inhibition  maturation  protein  animal cell  animal experiment  Article  bone marrow derived macrophage  cell death  cell protection  complex formation  controlled study  cytokine release  in vitro study  inflammation  mouse  nonhuman  priority journal  protein analysis  protein degradation  protein function  protein interaction  pyroptosis  animal  gene knockdown  genetics  immunology  macrophage  macrophage activation  metabolism  physiology  Murinae  Animals  CASP8 and FADD-Like Apoptosis Regulating Protein  Caspase 1  Caspase 8  Electron Transport Complex II  Gene Knockdown Techniques  Inflammasomes  Interleukin-1beta  Lipopolysaccharides  Macrophage Activation  Macrophages  Mice  NLR Family, Pyrin Domain-Containing 3 Protein  Pyroptosis  
Structure of the RNA-dependent RNA polymerase from COVID-19 virus 期刊论文
, 2020, 卷号: 368, 期号: 6492
作者:  Gao Y.;  Yan L.;  Huang Y.;  Liu F.;  Zhao Y.;  Cao L.;  Wang T.;  Sun Q.;  Ming Z.;  Zhang L.;  Ge J.;  Zheng L.;  Zhang Y.;  Wang H.;  Zhu Y.;  Zhu C.;  Hu T.;  Hua T.;  Zhang B.;  Yang X.;  Li J.;  Yang H.;  Liu Z.;  Xu W.;  Guddat L.W.;  Wang Q.;  Lou Z.;  Rao Z.
收藏  |  浏览/下载：44/0  |  提交时间：2020/07/28
comparative study  drug  electron microscopy  enzyme  enzyme activity  RNA  virus  Coronavirus  SARS coronavirus  adenosine phosphate  alanine  antivirus agent  NSP7 protein, SARS-CoV-2  NSP8 protein, SARS-CoV-2  remdesivir  RNA directed RNA polymerase  RNA-dependent RNA polymerase, coronavirus  viral protein  beta sheet  Betacoronavirus  chemistry  cryoelectron microscopy  drug design  enzyme active site  enzymology  metabolism  molecular model  protein domain  ultrastructure  Adenosine Monophosphate  Alanine  Antiviral Agents  Betacoronavirus  Catalytic Domain  Cryoelectron Microscopy  Drug Design  Models, Molecular  Protein Conformation, beta-Strand  Protein Domains  RNA Replicase  Viral Nonstructural Proteins  
Transcription polymerase-catalyzed emergence of novel RNA replicons 期刊论文
, 2020, 卷号: 368, 期号: 6487
作者:  Jain N.;  Blauch L.R.;  Szymanski M.R.;  Das R.;  Tang S.K.Y.;  Yin Y.W.;  Fire A.Z.
收藏  |  浏览/下载：33/0  |  提交时间：2020/07/28
cell component  enzyme  enzyme activity  genetic analysis  RNA  article  bacteriophage  catalysis  DNA replication origin  heredity  in vitro study  nonhuman  plant seed  replicon  RNA replication  synthesis  transcription initiation  biocatalysis  biosynthesis  genetic transcription  metabolism  Animalia  Hepatitis delta virus  Viroids  bacteriophage T7 RNA polymerase  DNA directed RNA polymerase  RNA  viral protein  Biocatalysis  DNA-Directed RNA Polymerases  Replicon  RNA  Transcription, Genetic  Viral Proteins  
Circadian rhythms in the absence of the clock gene Bmal1 期刊论文
, 2020, 卷号: 367, 期号: 6479
作者:  Ray S.;  Valekunja U.K.;  Stangherlin A.;  Howell S.A.;  Snijders A.P.;  Damodaran G.;  Reddy A.B.
收藏  |  浏览/下载：21/0  |  提交时间：2020/07/28
phosphoproteome  proteome  transcription factor ARNTL  transcription factor Ets  transcriptome  unclassified drug  cell component  circadian rhythm  gene  gene expression  genome  molecular analysis  animal experiment  animal tissue  Article  Bmal1 gene  circadian rhythm  controlled study  gene deletion  gene expression regulation  gene function  gene knockout  genotype  knockout mouse  light dark cycle  liver  mouse  nonhuman  oscillation  oxidation reduction potential  priority journal  RNA sequence  skin fibroblast  temperature  transcription regulation  Mammalia  Mus  
The Ccr4-Not complex monitors the translating ribosome for codon optimality 期刊论文
, 2020, 卷号: 368, 期号: 6488
作者:  Buschauer R.;  Matsuo Y.;  Sugiyama T.;  Chen Y.-H.;  Alhusaini N.;  Sweet T.;  Ikeuchi K.;  Cheng J.;  Matsuki Y.;  Nobuta R.;  Gilmozzi A.;  Berninghausen O.;  Tesina P.;  Becker T.;  Coller J.;  Inada T.;  Beckmann R.
收藏  |  浏览/下载：40/0  |  提交时间：2020/07/28
exonuclease  initiation factor 5A  messenger RNA  ribosome RNA  transfer RNA  ubiquitin protein ligase E3  bioassay  biomonitoring  cell component  plant and fungus structure and form  40S ribosomal subunit  adenylation  amino terminal sequence  Article  binding site  biochemical analysis  carbon catabolite repressor 4 negative on tata complex  codon  complex formation  controlled study  cryoelectron microscopy  homeostasis  molecular interaction  nonhuman  priority journal  protein conformation  ribosome  Saccharomyces cerevisiae  sequence analysis  ubiquitination  Saccharomyces cerevisiae  
Single-cell transcriptional diversity is a hallmark of developmental potential 期刊论文
, 2020, 卷号: 367, 期号: 6476
作者:  Gulati G.S.;  Sikandar S.S.;  Wesche D.J.;  Manjunath A.;  Bharadwaj A.;  Berger M.J.;  Ilagan F.;  Kuo A.H.;  Hsieh R.W.;  Cai S.;  Zabala M.;  Scheeren F.A.;  Lobo N.A.;  Qian D.;  Yu F.B.;  Dirbas F.M.;  Clarke M.F.;  Newman A.M.
收藏  |  浏览/下载：38/0  |  提交时间：2020/07/28
cell  cell component  developmental biology  experimental study  genetic analysis  tumor  Article  breast cancer  breast carcinogenesis  carcinogenesis  cell differentiation  computer model  embryonic stem cell  gene expression  genetic code  genetic variability  human  in vivo study  nonhuman  phenotype  priority journal  scoring system  single cell RNA seq  upregulation  
Very fast CRISPR on demand 期刊论文
, 2020, 卷号: 368, 期号: 6496
作者:  Liu Y.;  Zou R.S.;  He S.;  Nihongaki Y.;  Li X.;  Razavi S.;  Wu B.;  Ha T.
收藏  |  浏览/下载：20/0  |  提交时间：2020/07/28
Cas9 endonuclease Streptococcus pyogenes  double strand break repair protein MRE11  H2AX protein, human  histone  MRE11 protein, human  CRISPR Cas system  DNA cleavage  DNA repair  double stranded DNA break  fluorescence imaging  gene editing  genetics  HEK293 cell line  human  light  metabolism  phosphorylation  procedures  radiation response  single cell analysis  CRISPR-Associated Protein 9  CRISPR-Cas Systems  DNA Breaks, Double-Stranded  DNA Cleavage  DNA Repair  Gene Editing  HEK293 Cells  Histones  Humans  Light  MRE11 Homologue Protein  Optical Imaging  Phosphorylation  Single-Cell Analysis  
Dopaminylation of histone H3 in ventral tegmental area regulates cocaine seeking 期刊论文
, 2020, 卷号: 368, 期号: 6487
作者:  Lepack A.E.;  Werner C.T.;  Stewart A.F.;  Fulton S.L.;  Zhong P.;  Farrelly L.A.;  Smith A.C.W.;  Ramakrishnan A.;  Lyu Y.;  Bastle R.M.;  Martin J.A.;  Mitra S.;  O'Connor R.M.;  Wang Z.-J.;  Molina H.;  Turecki G.;  Shen L.;  Yan Z.;  Calipari E.S.;  Dietz D.M.;  Kenny P.J.;  Maze I.
收藏  |  浏览/下载：37/0  |  提交时间：2020/07/28
amidase  dopamine  histone H3  histone transamidase  protein glutamine gamma glutamyltransferase 2  RNA  unclassified drug  brain  cell  chemical compound  chemical reaction  gene expression  genetic analysis  protein  action potential  amino acid substitution  amino terminal sequence  Article  cocaine dependence  controlled study  dopamine release  dopaminergic nerve cell  dopaminergic transmission  down regulation  drug seeking behavior  enzyme activity  gene expression  histone dopaminylation  histone modification  human  human tissue  hyperpolarization  in vitro study  motivation  nerve cell plasticity  nerve projection  neuropathology  nucleus accumbens  priority journal  protein expression  protein function  reward  RNA sequence  ventral tegmentum  Rattus  
Marching to another clock 期刊论文
, 2020, 卷号: 367, 期号: 6479
作者:  Brown S.A.;  Sato M.
收藏  |  浏览/下载：36/0  |  提交时间：2020/07/28
RNA  transcription factor ARNTL  transcription factor CLOCK  transcription factor Ets  brain  circadian rhythm  molecular analysis  physiological response  protein  animal cell  animal tissue  Article  binding site  cell metabolism  circadian rhythm  controlled study  feedback system  genetic transcription  molecular dynamics  mouse  nonhuman  oxidation reduction reaction  priority journal  protein analysis  protein binding  protein expression  protein function  RNA analysis  RNA transcription  RNA translation  suprachiasmatic nucleus  music  walking  Circadian Rhythm  Music  Walking  
Deregulation of ribosomal protein expression and translation promotes breast cancer metastasis 期刊论文
, 2020, 卷号: 367, 期号: 6485
作者:  Ebright R.Y.;  Lee S.;  Wittner B.S.;  Niederhoffer K.L.;  Nicholson B.T.;  Bardia A.;  Truesdell S.;  Wiley D.F.;  Wesley B.;  Li S.;  Mai A.;  Aceto N.;  Vincent-Jordan N.;  Szabolcs A.;  Chirn B.;  Kreuzer J.;  Comaills V.;  Kalinich M.;  Haas W.;  Ting D.T.;  Toner M.;  Vasudevan S.;  Haber D.A.;  Maheswaran S.;  Micalizzi D.S.
收藏  |  浏览/下载：47/0  |  提交时间：2020/07/28
CRISPR associated protein  epidermal growth factor receptor 2  Ki 67 antigen  ribosome protein  ribosome RNA  transcription factor E2F  ribosome protein  cancer  cell  gene expression  genetic engineering  protein  RNA  tumor  animal experiment  animal model  animal tissue  Article  biogenesis  bioluminescence  breast cancer  cell cycle progression  cell cycle regulation  cell proliferation  circulating tumor cell  controlled study  enzyme activation  epithelial mesenchymal transition  gene expression profiling  genetic transcription  human  human cell  lung metastasis  metastasis  microfluidics  mouse  nonhuman  overall survival  phenotype  priority journal  progression free survival  promoter region  protein expression  protein processing  protein synthesis  proteomics  RNA sequence  transcription regulation  animal  breast tumor  cancer transplantation  CRISPR Cas system  female  gene expression regulation  genetics  pathology  sequence analysis  tumor cell line  tumor embolism  Mus  Animals  Breast Neoplasms  Cell Line, Tumor  CRISPR-Cas Systems  Female  Gene Expression Regulation, Neoplastic  Humans  Mice  Neoplasm Metastasis  Neoplasm Transplantation  Neoplastic Cells, Circulating  Ribosomal Proteins  Sequence Analysis, RNA