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Identification of an allosteric hotspot for additive activation of PPARγ in antidiabetic effects 期刊论文
Science Bulletin, 2021, 卷号: 66, 期号: 15
作者:  Feng L.;  Lu S.;  Zheng Z.;  Chen Y.;  Zhao Y.;  Song K.;  Xue H.;  Jin L.;  Li Y.;  Huang C.;  Li Y.-M.;  Zhang J.
收藏  |  浏览/下载：43/0  |  提交时间：2021/09/01
Additive activation  Allosteric hotspot  Cobinding  Combination therapy  PPARγ  Side effects  
Nanomedicine enables autophagy-enhanced cancer-cell ferroptosis 期刊论文
Science Bulletin, 2021, 卷号: 66, 期号: 5
作者:  Yang J.;  Ding L.;  Yu L.;  Wang Y.;  Ge M.;  Jiang Q.;  Chen Y.
收藏  |  浏览/下载：37/0  |  提交时间：2021/09/01
Autophagy  Ferroptosis  Manganese oxide  Mesoporous silica  Trehalose  Tumor therapy  
Tiny 2D silicon quantum sheets: a brain photonic nanoagent for orthotopic glioma theranostics 期刊论文
Science Bulletin, 2021, 卷号: 66, 期号: 2
作者:  Miao Z.;  Hu D.;  Gao D.;  Fan L.;  Ma Y.;  Ma T.;  Liu X.;  Zheng H.;  Zha Z.;  Sheng Z.;  Xu C.-Y.
收藏  |  浏览/下载：39/0  |  提交时间：2021/09/01
Orthotopic glioma  Photoacoustic imaging  Photothermal therapy  Theranostic agents  Two-dimensional (2D) silicon  
Imaging strategies using cyanine probes and materials for biomedical visualization of live animals 期刊论文
COORDINATION CHEMISTRY REVIEWS, 2021, 卷号: 447
作者:  Fei, Guiqiang;  Ma, Siyue;  Wang, Chao;  Chen, Tao;  Li, Yulin;  Liu, Yuxia;  Tang, Bo;  James, Tony D.;  Chen, Guang
收藏  |  浏览/下载：34/0  |  提交时间：2022/04/28
INFRARED FLUORESCENT-PROBE  HIGHLY SELECTIVE DETECTION  IN-VIVO  SUPEROXIDE ANION  PHOTODYNAMIC THERAPY  ENHANCED PROBE  CELLS  MICE  PHOTOSTABILITY  GLUTATHIONE  
Janus γ-Fe2O3/SiO2-based nanotheranostics for dual-modal imaging and enhanced synergistic cancer starvation/chemodynamic therapy 期刊论文
Science Bulletin, 2020, 卷号: 65, 期号: 7
作者:  Zhang Y.;  Wan Y.;  Liao Y.;  Hu Y.;  Jiang T.;  He T.;  Bi W.;  Lin J.;  Gong P.;  Tang L.;  Huang P.
收藏  |  浏览/下载：28/0  |  提交时间：2021/09/01
Fenton-like reaction  Glucose oxidase  Janus nanoparticles  Synergistic therapy  Theranostics  
Biomaterial scaffold-based local drug delivery systems for cancer immunotherapy 期刊论文
Science Bulletin, 2020, 卷号: 65, 期号: 17
作者:  Yang C.;  Blum N.T.;  Lin J.;  Qu J.;  Huang P.
收藏  |  浏览/下载：28/0  |  提交时间：2021/09/01
Cancer immunotherapy  Combination therapy  Controlled drug delivery  Hydrogel  Local drug delivery system  Scaffold  
Therapeutic targeting of preleukemia cells in a mouse model of NPM1 mutant acute myeloid leukemia 期刊论文
, 2020, 卷号: 367, 期号: 6477
作者:  Uckelmann H.J.;  Kim S.M.;  Wong E.M.;  Hatton C.;  Giovinazzo H.;  Gadrey J.Y.;  Krivtsov A.V.;  Rücker F.G.;  Döhner K.;  McGeehan G.M.;  Levine R.L.;  Bullinger L.;  Vassiliou G.S.;  Armstrong S.A.
收藏  |  浏览/下载：36/0  |  提交时间：2020/07/28
antileukemic agent  methionine  unclassified drug  vtp 50469  biological development  cancer  cell  disease treatment  mutation  numerical model  oral health  acute myeloid leukemia  animal cell  animal experiment  animal model  antineoplastic activity  Article  cell proliferation  cell self-renewal  chromatin  controlled study  drug targeting  gene  gene mutation  leukemia cell  molecularly targeted therapy  mouse  mouse model  nonhuman  NPM1 gene  preleukemia  priority journal  Mus  
Meet the psychobiome 期刊论文
, 2020, 卷号: 368, 期号: 6491
作者:  Pennisi E.
收藏  |  浏览/下载：29/0  |  提交时间：2020/07/28
4 aminobutyric acid  antibiotic agent  dopamine  kynurenine  probiotic agent  queuine  serotonin  psychotropic agent  bacterium  biome  drug  microbial activity  nervous system disorder  allergy  Alzheimer disease  antimicrobial therapy  anxiety disorder  archaeon  Article  autism  bacterium culture  Bacteroides  blood brain barrier  blood vessel  brain disease  clinical effectiveness  constipation  depression  drug use  enteroendocrine cell  enteropathy  entrepreneurship  epilepsy  fecal microbiota transplantation  feces analysis  Food and Drug Administration  fungus  genomics  human  insomnia  intestine flora  irritable colon  mammal cell  microbiology  microbiome  nerve cell  nervous system  nervous system development  neurologic disease  nonhuman  obesity  pain threshold  Parkinson disease  physician  priority journal  psychobiome  psychological aspect  psychological well-being  schizophrenia  scientist  United States  vagus nerve  virus  animal  bacterium  chemistry  drug development  intestine flora  isolation and purification  metabolism  microbiology  physiology  procedures  Animals  Bacteria  Drug Discovery  Gastrointestinal Microbiome  Humans  Nervous System Diseases  Psychotropic Drugs  
Effect of tolerance on the evolution of antibiotic resistance under drug combinations 期刊论文
, 2020, 卷号: 367, 期号: 6474
作者:  Liu J.;  Gefen O.;  Ronin I.;  Bar-Meir M.;  Balaban N.Q.
收藏  |  浏览/下载：18/0  |  提交时间：2020/07/28
daptomycin  rifampicin  vancomycin  antiinfective agent  beta' subunit of RNA polymerase  daptomycin  DNA directed RNA polymerase  rifampicin  vancomycin  antibiotic resistance  bacterium  emergence  evolutionary biology  experimental study  laboratory method  survival  adult  antibiotic resistance  Article  bacterial mutation  bacterial strain  bacterium isolation  clinical article  colony forming unit  combination drug therapy  drug effect  drug tolerance  human  in vitro study  minimum inhibitory concentration  nonhuman  phylogeny  priority journal  Staphylococcus aureus  whole genome sequencing  antibiotic resistance  combination drug therapy  drug effect  genetics  methicillin resistant Staphylococcus aureus  microbial sensitivity test  microbiology  molecular evolution  mutation  single nucleotide polymorphism  Staphylococcus infection  Staphylococcus aureus  Anti-Bacterial Agents  Daptomycin  DNA-Directed RNA Polymerases  Drug Resistance, Microbial  Drug Therapy, Combination  Evolution, Molecular  Humans  Methicillin-Resistant Staphylococcus aureus  Microbial Sensitivity Tests  Mutation  Polymorphism, Single Nucleotide  Rifampin  Staphylococcal Infections  Vancomycin  
Regenerative potential of prostate luminal cells revealed by single-cell analysis 期刊论文
, 2020, 卷号: 368, 期号: 6490
作者:  Karthaus W.R.;  Hofree M.;  Choi D.;  Linton E.L.;  Turkekul M.;  Bejnood A.;  Carver B.;  Gopalan A.;  Abida W.;  Laudone V.;  Biton M.;  Chaudhary O.;  Xu T.;  Masilionis I.;  Manova K.;  Mazutis L.;  Pe’er D.;  Regev A.;  Sawyers C.L.
收藏  |  浏览/下载：205/0  |  提交时间：2020/07/28
androgen  growth factor  Nrg2 growth factor  Rspo3 growth factor  unclassified drug  androgen binding protein  antiandrogen  ataxin 1  Atxn1 protein, mouse  glycosylphosphatidylinositol anchored protein  homeodomain protein  nerve growth factor  Nkx3-1 protein, mouse  Nrg2 protein, mouse  probasin  Psca protein, mouse  R-spondin3 protein, mouse  thrombospondin  transcription factor  tumor antigen  tumor protein  androgen  cancer  cell  gene expression  RNA  rodent  ablation therapy  animal cell  animal tissue  Article  cell differentiation  cell population  cell regeneration  cells by body anatomy  controlled study  gene  gene expression  human  luminal cell  male  mesenchyme cell  mouse  nonhuman  paracrine signaling  priority journal  prostate cell  prostate tissue  protein expression  Psca gene  RNA sequencing  Sca1 gene  single cell analysis  animal  genetics  mesenchymal stem cell  metabolism  organ size  organoid  physiology  prostate  prostate tumor  regeneration  sequence analysis  single cell analysis  Mus  Androgen Antagonists  Androgen-Binding Protein  Androgens  Animals  Antigens, Neoplasm  Ataxin-1  Cell Differentiation  Gene Expression  GPI-Linked Proteins  Homeodomain Proteins  Humans  Male  Mesenchymal Stem Cells  Mice  Neoplasm Proteins  Nerve Growth Factors  Organ Size  Organoids  Prostate  Prostatic Neoplasms  Regeneration  Sequence Analysis, RNA  Single-Cell Analysis  Thrombospondins  Transcription Factors