气候变化领域集成服务门户(CCPortal): Tiny 2D silicon quantum sheets: a brain photonic nanoagent for orthotopic glioma theranostics

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DOI	10.1016/j.scib.2020.09.027
	Tiny 2D silicon quantum sheets: a brain photonic nanoagent for orthotopic glioma theranostics
	Miao Z.; Hu D.; Gao D.; Fan L.; Ma Y.; Ma T.; Liu X.; Zheng H.; Zha Z.; Sheng Z.; Xu C.-Y.
发表日期	2021
ISSN	20959273
起始页码	147
结束页码	157
卷号	66 期号:2
英文摘要	We report that atomically thin two-dimensional silicon quantum sheets (2D Si QSs), prepared by a scalable approach coupling chemical delithiation and cryo-assisted exfoliation, can serve as a high-performance brain photonic nanoagent for orthotopic glioma theranostics. With the lateral size of approximately 14.0 nm and thickness of about 1.6 nm, tiny Si QSs possess high mass extinction coefficient of 27.5 L g−1 cm−1 and photothermal conversion efficiency of 47.2% at 808 nm, respectively, concurrently contributing to the best photothermal performance among the reported 2D mono-elemental materials (Xenes). More importantly, Si QSs with low toxicity maintain the trade-off between stability and degradability, paving the way for practical clinical translation in consideration of both storage and action of nanoagents. In vitro Transwell filter experiment reveals that Si QSs could effectively go across the bEnd.3 cells monolayer. Upon the intravenous injection of Si QSs, orthotopic brain tumors are effectively inhibited under the precise guidance of photoacoustic imaging, and the survival lifetime of brain tumor-bearing mice is increased by two fold. Atomically thin Si QSs with strong light-harvesting capability are expected to provide an effective and robust 2D photonic nanoplatform for the management of brain diseases. © 2020 Science China Press
关键词	Orthotopic glioma Photoacoustic imaging Photothermal therapy Theranostic agents Two-dimensional (2D) silicon
英文关键词	Brain; Economic and social effects; Mammals; Theranostics; Tumors; Chemical delithiation; Clinical translation; Intravenous injections; Light-harvesting; Mass extinction coefficients; Photo-acoustic imaging; Photothermal conversion efficiencies; Scalable approach; Silicon
语种	英语
来源期刊	Science Bulletin
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/207527
作者单位	School of Food and Biological Engineering, Hefei University of Technology, Hefei, 230009, China; Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Key Laboratory of Ultrasound Imaging and Therapy, Institute of Biomedical and Health Engineering, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China; Shenzhen Bay Laboratory, Shenzhen, 518107, China; School of Materials Science and Engineering, Harbin Institute of Technology (Shenzhen), Shenzhen, 518055, China
推荐引用方式 GB/T 7714	Miao Z.,Hu D.,Gao D.,et al. Tiny 2D silicon quantum sheets: a brain photonic nanoagent for orthotopic glioma theranostics[J],2021,66(2).
APA	Miao Z..,Hu D..,Gao D..,Fan L..,Ma Y..,...&Xu C.-Y..(2021).Tiny 2D silicon quantum sheets: a brain photonic nanoagent for orthotopic glioma theranostics.Science Bulletin,66(2).
MLA	Miao Z.,et al."Tiny 2D silicon quantum sheets: a brain photonic nanoagent for orthotopic glioma theranostics".Science Bulletin 66.2(2021).