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DOI	10.1016/j.ccr.2021.214134
	Imaging strategies using cyanine probes and materials for biomedical visualization of live animals
	Fei, Guiqiang; Ma, Siyue; Wang, Chao; Chen, Tao; Li, Yulin; Liu, Yuxia; Tang, Bo; James, Tony D.; Chen, Guang
通讯作者	Liu, YX ; James, TD ; Chen, G (通讯作者)，Shaanxi Univ Sci & Technol, Coll Chem & Chem Engn, Shaanxi Key Lab Chem Addit Ind, Xian 710021, Peoples R China. ; Tang, B ; Chen, G (通讯作者)，Shandong Normal Univ, Coll Chem Chem Engn & Mat Sci, Jinan 250014, Shandong, Peoples R China. ; James, TD (通讯作者)，Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England. ; Liu, YX ; Chen, G (通讯作者)，Univ Waterloo, Dept Chem Engn, 200 Univ Ave West, Waterloo, ON N2L 3G1, Canada. ; Liu, YX ; Chen, G (通讯作者)，Univ Waterloo, Waterloo Inst Nanotechnol, 200 Univ Ave West, Waterloo, ON N2L 3G1, Canada. ; James, TD (通讯作者)，Henan Normal Univ, Sch Chem & Chem Engn, Xinxiang 453007, Henan, Peoples R China.
发表日期	2021
ISSN	0010-8545
EISSN	1873-3840
卷号	447
英文摘要	In vivo fluorescence imaging provides vital information required for biomedical research in living animals, and as such plays an essential role in disease assessment. Unfortunately, due to the lack of coherent approaches, in vivo fluorescence visualization is challenging, wasting not only time but the animals used. In recent years, cyanine-based systems have been found to exhibit attractive optical properties with appropriate bio-functionality and therefore have become go-to probes for in vivo research. Herein, we collected the recent breakthroughs using cyanine-based systems associated with use in living mammals, to provide researchers with the required information to develop appropriate strategies able to meet the increasing stringent requirements for practical applications. We concentrate on 6 sites within the cyanine skeleton, including the: meso-position (1), N-indole (2), phenyl-indole (2), cyclohexane (1), which have been used to design symmetric or asymmetric cyanine structures. Substitutions at the meso-position provide fluorescence probes featuring a switch of EWG and EDG, PET, spiro-cyclization, ICT within the cyanine skeleton, or FRET, for visualizing analytes in vivo. Substitution at the N-indole forms a positively charged system with long wavelength emission suitable for in vivo imaging. While, modification of the phenyl-indole contributes to the functional properties, including photoacoustic, photothermal and photodynamic behavior, which can be used for multimodal imaging as well as functional imaging in vivo. With a specific trigger at the N-indole or meso-position, NIR fluorescence pro-drugs could be developed for in vivo tracing of the efficiency of drug delivery. While modification of the cyclohexane can introduce a targeting moiety for the accurate monitoring of tumors or organs. Using these strategies appropriate design platforms can be developed to provide the next generation of optical systems for living animal research. Moreover, we hope this review will enable researchers to design systems with high efficiency for in vivo research, which will reduce both the development time and number of animals required to progress the research. (C) 2021 Elsevier B.V. All rights reserved.
关键词	INFRARED FLUORESCENT-PROBE HIGHLY SELECTIVE DETECTION IN-VIVO SUPEROXIDE ANION PHOTODYNAMIC THERAPY ENHANCED PROBE CELLS MICE PHOTOSTABILITY GLUTATHIONE
英文关键词	In vivo fluorescence imaging; Strategies; Cyanine; Biomedical visualization
语种	英语
WOS研究方向	Chemistry
WOS类目	Chemistry, Inorganic & Nuclear
WOS记录号	WOS:000692520700002
来源期刊	COORDINATION CHEMISTRY REVIEWS
来源机构	中国科学院西北生态环境资源研究院
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/255168
作者单位	[Fei, Guiqiang; Ma, Siyue; Wang, Chao; Liu, Yuxia; James, Tony D.; Chen, Guang] Shaanxi Univ Sci & Technol, Coll Chem & Chem Engn, Shaanxi Key Lab Chem Addit Ind, Xian 710021, Peoples R China; [Tang, Bo; Chen, Guang] Shandong Normal Univ, Coll Chem Chem Engn & Mat Sci, Jinan 250014, Shandong, Peoples R China; [James, Tony D.] Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England; [Liu, Yuxia; Chen, Guang] Univ Waterloo, Dept Chem Engn, 200 Univ Ave West, Waterloo, ON N2L 3G1, Canada; [Liu, Yuxia; Chen, Guang] Univ Waterloo, Waterloo Inst Nanotechnol, 200 Univ Ave West, Waterloo, ON N2L 3G1, Canada; [Chen, Tao; Li, Yulin] Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Tibetan Med Res, Qinghai Key Lab Qinghai Tibet Plateau Biol Resour, Xining 810001, Qinghai, Peoples R China; [James, Tony D.] Henan Normal Univ, Sch Chem & Chem Engn, Xinxiang 453007, Henan, Peoples R China
推荐引用方式 GB/T 7714	Fei, Guiqiang,Ma, Siyue,Wang, Chao,et al. Imaging strategies using cyanine probes and materials for biomedical visualization of live animals[J]. 中国科学院西北生态环境资源研究院,2021,447.
APA	Fei, Guiqiang.,Ma, Siyue.,Wang, Chao.,Chen, Tao.,Li, Yulin.,...&Chen, Guang.(2021).Imaging strategies using cyanine probes and materials for biomedical visualization of live animals.COORDINATION CHEMISTRY REVIEWS,447.
MLA	Fei, Guiqiang,et al."Imaging strategies using cyanine probes and materials for biomedical visualization of live animals".COORDINATION CHEMISTRY REVIEWS 447(2021).